Advanced

Nano-objects emitted during maintenance of common particle generators: direct chemical characterization with aerosol mass spectrometry and implications for risk assessments

Nilsson, Patrik LU ; Isaxon, Christina LU ; Eriksson, Axel LU ; Messing, Maria LU ; Ludvigsson, Linus LU ; Rissler, Jenny LU ; Hedmer, Maria LU ; Tinnerberg, Håkan LU ; Gudmundsson, Anders LU and Deppert, Knut LU , et al. (2013) In Journal of Nanoparticle Research 15.
Abstract
Nanotechnology gives us materials with enhanced or completely new properties. At the same time, inhalation of manufactured nano-objects has been related to an array of adverse biological effects. We characterized particle emissions, which occurred during maintenance of common metal nanoparticle generators and contrasted the properties of the emitted particles with those originally produced by the generators. A new approach using online aerosol mass spectrometry (AMS), for time-and size-resolved measurements of the particle chemical composition, was applied in combination with more conventional techniques for particle sampling and analysis, including electron microscopy. Emissions during maintenance work, in terms of mass and surface area... (More)
Nanotechnology gives us materials with enhanced or completely new properties. At the same time, inhalation of manufactured nano-objects has been related to an array of adverse biological effects. We characterized particle emissions, which occurred during maintenance of common metal nanoparticle generators and contrasted the properties of the emitted particles with those originally produced by the generators. A new approach using online aerosol mass spectrometry (AMS), for time-and size-resolved measurements of the particle chemical composition, was applied in combination with more conventional techniques for particle sampling and analysis, including electron microscopy. Emissions during maintenance work, in terms of mass and surface area concentration in the size range of 0.02-10 mu m, were dominated by large agglomerates (1-5 mu m). With AMS, we show that the particle composition depends on both generator type and maintenance task being performed and that the instrument can be used for highly time-resolved selective studies of metal nanoparticle emissions. The emitted agglomerates have a relatively high probability to be deposited in the lower respiratory tract, since the mean particle diameter coincided with a peak in the lung deposition curve. Each of these agglomerates consisted of a very high number (10(3)-10(5)/agglomerate) of nanometer-sized primary particles originating from the particle synthesis process. This made them possess large surface areas, one of the key properties in nanotoxicology. Similar agglomerates may be emitted in a wide range of processes when nanoparticles are manufactured or handled. The fate of such agglomerates, once deposited in the respiratory tract, is unknown and should therefore be considered in future particle toxicological studies. Our results highlight the importance of including micrometer-sized particles in exposure and emission assessments. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Engineered nanoparticles, Occupational, Risk, Dosimetry, AMS, Emission
in
Journal of Nanoparticle Research
volume
15
publisher
Springer
external identifiers
  • wos:000325855200001
  • scopus:84892637923
ISSN
1572-896X
DOI
10.1007/s11051-013-2052-0
project
MERGE
language
English
LU publication?
yes
id
2b0e24d6-5fca-45ce-9dc1-cc82d6df8946 (old id 4158060)
date added to LUP
2013-12-04 13:20:59
date last changed
2019-03-12 09:27:30
@article{2b0e24d6-5fca-45ce-9dc1-cc82d6df8946,
  abstract     = {Nanotechnology gives us materials with enhanced or completely new properties. At the same time, inhalation of manufactured nano-objects has been related to an array of adverse biological effects. We characterized particle emissions, which occurred during maintenance of common metal nanoparticle generators and contrasted the properties of the emitted particles with those originally produced by the generators. A new approach using online aerosol mass spectrometry (AMS), for time-and size-resolved measurements of the particle chemical composition, was applied in combination with more conventional techniques for particle sampling and analysis, including electron microscopy. Emissions during maintenance work, in terms of mass and surface area concentration in the size range of 0.02-10 mu m, were dominated by large agglomerates (1-5 mu m). With AMS, we show that the particle composition depends on both generator type and maintenance task being performed and that the instrument can be used for highly time-resolved selective studies of metal nanoparticle emissions. The emitted agglomerates have a relatively high probability to be deposited in the lower respiratory tract, since the mean particle diameter coincided with a peak in the lung deposition curve. Each of these agglomerates consisted of a very high number (10(3)-10(5)/agglomerate) of nanometer-sized primary particles originating from the particle synthesis process. This made them possess large surface areas, one of the key properties in nanotoxicology. Similar agglomerates may be emitted in a wide range of processes when nanoparticles are manufactured or handled. The fate of such agglomerates, once deposited in the respiratory tract, is unknown and should therefore be considered in future particle toxicological studies. Our results highlight the importance of including micrometer-sized particles in exposure and emission assessments.},
  author       = {Nilsson, Patrik and Isaxon, Christina and Eriksson, Axel and Messing, Maria and Ludvigsson, Linus and Rissler, Jenny and Hedmer, Maria and Tinnerberg, Håkan and Gudmundsson, Anders and Deppert, Knut and Bohgard, Mats and Pagels, Joakim},
  issn         = {1572-896X},
  keyword      = {Engineered nanoparticles,Occupational,Risk,Dosimetry,AMS,Emission},
  language     = {eng},
  publisher    = {Springer},
  series       = {Journal of Nanoparticle Research},
  title        = {Nano-objects emitted during maintenance of common particle generators: direct chemical characterization with aerosol mass spectrometry and implications for risk assessments},
  url          = {http://dx.doi.org/10.1007/s11051-013-2052-0},
  volume       = {15},
  year         = {2013},
}