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Calcium-activated chloride channel regulator 1 as a prognostic biomarker in pancreatic ductal adenocarcinoma

Hu, Dingyuan LU ; Ansari, Daniel LU ; Zhou, Qimin LU orcid ; Sasor, Agata LU ; Hilmersson, Katarzyna Said LU ; Bauden, Monika LU orcid ; Jiang, Yi and Andersson, Roland LU (2018) In BMC Cancer 18(1).
Abstract

BACKGROUND: In a previous study utilizing mass spectrometry-based proteomics, we identified calcium-activated chloride channel regulator 1 (CLCA1) as a potential tumor suppressor in pancreatic cancer and the expression was inversely correlated with patient survival. The aim of the study was to further validate the prognostic significance of CLCA1 in pancreatic cancer. METHODS: CLCA1 expression was evaluated with tissue microarrays and immunohistochemistry in 140 patients with pancreatic ductal adenocarcinoma that underwent surgical resection at Skåne University Hospital, Sweden. Kaplan-Meier and Cox proportional hazards modeling were used to explore the association between CLCA1 and clinicopathological factors and survival. RESULTS:... (More)

BACKGROUND: In a previous study utilizing mass spectrometry-based proteomics, we identified calcium-activated chloride channel regulator 1 (CLCA1) as a potential tumor suppressor in pancreatic cancer and the expression was inversely correlated with patient survival. The aim of the study was to further validate the prognostic significance of CLCA1 in pancreatic cancer. METHODS: CLCA1 expression was evaluated with tissue microarrays and immunohistochemistry in 140 patients with pancreatic ductal adenocarcinoma that underwent surgical resection at Skåne University Hospital, Sweden. Kaplan-Meier and Cox proportional hazards modeling were used to explore the association between CLCA1 and clinicopathological factors and survival. RESULTS: CLCA1 expression was denoted as positive in 90 tumors (64.3%), with positive staining being limited to the tumor cells. There were no significant association between CLCA1 expression and established clinicopathological parameters. Low CLCA1 expression correlated significantly with shorter disease-free survival (11.9 vs 17.5 months, P = 0.042). Multivariable Cox regression analysis confirmed the results (HR 0.61, 95% CI-0.40-0.92, P = 0.019). CONCLUSIONS: Low CLCA1 expression is an independent factor of poor disease-free survival in pancreatic cancer.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Calcium-activated chloride channel regulators, CLCA1, Pancreatic ductal adenocarcinoma, Survival
in
BMC Cancer
volume
18
issue
1
pages
1 pages
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85056335933
  • pmid:30419838
ISSN
1471-2407
DOI
10.1186/s12885-018-5013-2
language
English
LU publication?
yes
id
2bacad4e-f52c-44f1-a28b-506b4ecc3cf9
date added to LUP
2018-11-21 14:37:46
date last changed
2024-06-26 03:24:19
@article{2bacad4e-f52c-44f1-a28b-506b4ecc3cf9,
  abstract     = {{<p>BACKGROUND: In a previous study utilizing mass spectrometry-based proteomics, we identified calcium-activated chloride channel regulator 1 (CLCA1) as a potential tumor suppressor in pancreatic cancer and the expression was inversely correlated with patient survival. The aim of the study was to further validate the prognostic significance of CLCA1 in pancreatic cancer. METHODS: CLCA1 expression was evaluated with tissue microarrays and immunohistochemistry in 140 patients with pancreatic ductal adenocarcinoma that underwent surgical resection at Skåne University Hospital, Sweden. Kaplan-Meier and Cox proportional hazards modeling were used to explore the association between CLCA1 and clinicopathological factors and survival. RESULTS: CLCA1 expression was denoted as positive in 90 tumors (64.3%), with positive staining being limited to the tumor cells. There were no significant association between CLCA1 expression and established clinicopathological parameters. Low CLCA1 expression correlated significantly with shorter disease-free survival (11.9 vs 17.5 months, P = 0.042). Multivariable Cox regression analysis confirmed the results (HR 0.61, 95% CI-0.40-0.92, P = 0.019). CONCLUSIONS: Low CLCA1 expression is an independent factor of poor disease-free survival in pancreatic cancer.</p>}},
  author       = {{Hu, Dingyuan and Ansari, Daniel and Zhou, Qimin and Sasor, Agata and Hilmersson, Katarzyna Said and Bauden, Monika and Jiang, Yi and Andersson, Roland}},
  issn         = {{1471-2407}},
  keywords     = {{Calcium-activated chloride channel regulators; CLCA1; Pancreatic ductal adenocarcinoma; Survival}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Cancer}},
  title        = {{Calcium-activated chloride channel regulator 1 as a prognostic biomarker in pancreatic ductal adenocarcinoma}},
  url          = {{http://dx.doi.org/10.1186/s12885-018-5013-2}},
  doi          = {{10.1186/s12885-018-5013-2}},
  volume       = {{18}},
  year         = {{2018}},
}