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Familial risks and proportions describing population landscape of familial cancer

Hemminki, Kari LU ; Sundquist, Kristina LU ; Sundquist, Jan LU ; Försti, Asta LU ; Hemminki, Akseli and Li, Xinjun LU (2021) In Cancers 13(17).
Abstract

Background: Familial cancer can be defined through the occurrence of the same cancer in two or more family members. We describe a nationwide landscape of familial cancer, including its frequency and the risk that it conveys, by using the largest family database in the world with complete family structures and medically confirmed cancers. Patients/methods: We employed standardized incidence ratios (SIRs) to estimate familial risks for concordant cancer among first-degree relatives using the Swedish Cancer Registry from years 1958 through 2016. Results: Cancer risks in a 20–84 year old population conferred by affected parents or siblings were about two-fold compared to the risk for individuals with unaffected relatives. For small... (More)

Background: Familial cancer can be defined through the occurrence of the same cancer in two or more family members. We describe a nationwide landscape of familial cancer, including its frequency and the risk that it conveys, by using the largest family database in the world with complete family structures and medically confirmed cancers. Patients/methods: We employed standardized incidence ratios (SIRs) to estimate familial risks for concordant cancer among first-degree relatives using the Swedish Cancer Registry from years 1958 through 2016. Results: Cancer risks in a 20–84 year old population conferred by affected parents or siblings were about two-fold compared to the risk for individuals with unaffected relatives. For small intestinal, testicular, thyroid and bone cancers and Hodgkin disease, risks were higher, five-to-eight-fold. Novel familial associations included adult bone, lip, pharyngeal, and connective tissue cancers. Familial cancers were found in 13.2% of families with cancer; for prostate cancer, the proportion was 26.4%. High-risk families accounted for 6.6% of all cancer families. Discussion/Conclusion: High-risk family history should be exceedingly considered for management, including targeted genetic testing. For the major proportion of familial clustering, where genetic testing may not be feasible, medical and behavioral intervention should be indicated for the patient and their family members, including screening recommendations and avoidance of carcinogenic exposure.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Familial proportion, Familial risk, Family-cancer database, High-risk families, Nationwide study
in
Cancers
volume
13
issue
17
article number
4385
publisher
MDPI AG
external identifiers
  • pmid:34503195
  • scopus:85113881203
ISSN
2072-6694
DOI
10.3390/cancers13174385
language
English
LU publication?
yes
id
2c03bc6f-f795-4d30-a711-f3a2e0b424c2
date added to LUP
2021-09-17 15:29:17
date last changed
2024-05-04 12:28:01
@article{2c03bc6f-f795-4d30-a711-f3a2e0b424c2,
  abstract     = {{<p>Background: Familial cancer can be defined through the occurrence of the same cancer in two or more family members. We describe a nationwide landscape of familial cancer, including its frequency and the risk that it conveys, by using the largest family database in the world with complete family structures and medically confirmed cancers. Patients/methods: We employed standardized incidence ratios (SIRs) to estimate familial risks for concordant cancer among first-degree relatives using the Swedish Cancer Registry from years 1958 through 2016. Results: Cancer risks in a 20–84 year old population conferred by affected parents or siblings were about two-fold compared to the risk for individuals with unaffected relatives. For small intestinal, testicular, thyroid and bone cancers and Hodgkin disease, risks were higher, five-to-eight-fold. Novel familial associations included adult bone, lip, pharyngeal, and connective tissue cancers. Familial cancers were found in 13.2% of families with cancer; for prostate cancer, the proportion was 26.4%. High-risk families accounted for 6.6% of all cancer families. Discussion/Conclusion: High-risk family history should be exceedingly considered for management, including targeted genetic testing. For the major proportion of familial clustering, where genetic testing may not be feasible, medical and behavioral intervention should be indicated for the patient and their family members, including screening recommendations and avoidance of carcinogenic exposure.</p>}},
  author       = {{Hemminki, Kari and Sundquist, Kristina and Sundquist, Jan and Försti, Asta and Hemminki, Akseli and Li, Xinjun}},
  issn         = {{2072-6694}},
  keywords     = {{Familial proportion; Familial risk; Family-cancer database; High-risk families; Nationwide study}},
  language     = {{eng}},
  number       = {{17}},
  publisher    = {{MDPI AG}},
  series       = {{Cancers}},
  title        = {{Familial risks and proportions describing population landscape of familial cancer}},
  url          = {{http://dx.doi.org/10.3390/cancers13174385}},
  doi          = {{10.3390/cancers13174385}},
  volume       = {{13}},
  year         = {{2021}},
}