Meteorin is a chemokinetic factor in neuroblast migration and promotes stroke-induced striatal neurogenesis.
Wang, Zhaolu LU ; Andrade, Nuno ; Torp, Malene ; Wattananit, Somsak LU ; Arvidsson, Andreas LU ; Kokaia, Zaal LU
; Jørgensen, Jesper Roland
and Lindvall, Olle
LU
(2012)
In Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
32.
p.387-398
- Abstract
- Ischemic stroke affecting the adult brain causes increased progenitor proliferation in the subventricular zone (SVZ) and generation of neuroblasts, which migrate into the damaged striatum and differentiate to mature neurons. Meteorin (METRN), a newly discovered neurotrophic factor, is highly expressed in neural progenitor cells and immature neurons during development, suggesting that it may be involved in neurogenesis. Here, we show that METRN promotes migration of neuroblasts from SVZ explants of postnatal rats and stroke-subjected adult rats via a chemokinetic mechanism, and reduces N-methyl-D-asparate-induced apoptotic cell death in SVZ cells in vitro. Stroke induced by middle cerebral artery occlusion upregulates the expression of... (More)
- Ischemic stroke affecting the adult brain causes increased progenitor proliferation in the subventricular zone (SVZ) and generation of neuroblasts, which migrate into the damaged striatum and differentiate to mature neurons. Meteorin (METRN), a newly discovered neurotrophic factor, is highly expressed in neural progenitor cells and immature neurons during development, suggesting that it may be involved in neurogenesis. Here, we show that METRN promotes migration of neuroblasts from SVZ explants of postnatal rats and stroke-subjected adult rats via a chemokinetic mechanism, and reduces N-methyl-D-asparate-induced apoptotic cell death in SVZ cells in vitro. Stroke induced by middle cerebral artery occlusion upregulates the expression of endogenous METRN in cells with neuronal phenotype in striatum. Recombinant METRN infused into the stroke-damaged brain stimulates cell proliferation in SVZ, promotes neuroblast migration, and increases the number of immature and mature neurons in the ischemic striatum. Our findings identify METRN as a new factor promoting neurogenesis both in vitro and in vivo by multiple mechanisms. Further work will be needed to translate METRN's actions on endogenous neurogenesis into improved recovery after stroke.Journal of Cerebral Blood Flow & Metabolism advance online publication, 2 November 2011; doi:10.1038/jcbfm.2011.156. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2221288
- author
- Wang, Zhaolu
LU
; Andrade, Nuno
; Torp, Malene
; Wattananit, Somsak
LU
; Arvidsson, Andreas
LU
; Kokaia, Zaal
LU
; Jørgensen, Jesper Roland
and Lindvall, Olle
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
- volume
- 32
- pages
- 387 - 398
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000299857200018
- pmid:22044868
- scopus:84856418869
- pmid:22044868
- ISSN
- 1559-7016
- DOI
- 10.1038/jcbfm.2011.156
- language
- English
- LU publication?
- yes
- id
- 2c0709ca-aed1-41b7-bd6a-cd0571417224 (old id 2221288)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22044868?dopt=Abstract
- date added to LUP
- 2016-04-04 09:41:29
- date last changed
- 2022-03-15 20:34:30
@article{2c0709ca-aed1-41b7-bd6a-cd0571417224,
abstract = {{Ischemic stroke affecting the adult brain causes increased progenitor proliferation in the subventricular zone (SVZ) and generation of neuroblasts, which migrate into the damaged striatum and differentiate to mature neurons. Meteorin (METRN), a newly discovered neurotrophic factor, is highly expressed in neural progenitor cells and immature neurons during development, suggesting that it may be involved in neurogenesis. Here, we show that METRN promotes migration of neuroblasts from SVZ explants of postnatal rats and stroke-subjected adult rats via a chemokinetic mechanism, and reduces N-methyl-D-asparate-induced apoptotic cell death in SVZ cells in vitro. Stroke induced by middle cerebral artery occlusion upregulates the expression of endogenous METRN in cells with neuronal phenotype in striatum. Recombinant METRN infused into the stroke-damaged brain stimulates cell proliferation in SVZ, promotes neuroblast migration, and increases the number of immature and mature neurons in the ischemic striatum. Our findings identify METRN as a new factor promoting neurogenesis both in vitro and in vivo by multiple mechanisms. Further work will be needed to translate METRN's actions on endogenous neurogenesis into improved recovery after stroke.Journal of Cerebral Blood Flow & Metabolism advance online publication, 2 November 2011; doi:10.1038/jcbfm.2011.156.}},
author = {{Wang, Zhaolu and Andrade, Nuno and Torp, Malene and Wattananit, Somsak and Arvidsson, Andreas and Kokaia, Zaal and Jørgensen, Jesper Roland and Lindvall, Olle}},
issn = {{1559-7016}},
language = {{eng}},
pages = {{387--398}},
publisher = {{Nature Publishing Group}},
series = {{Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism}},
title = {{Meteorin is a chemokinetic factor in neuroblast migration and promotes stroke-induced striatal neurogenesis.}},
url = {{http://dx.doi.org/10.1038/jcbfm.2011.156}},
doi = {{10.1038/jcbfm.2011.156}},
volume = {{32}},
year = {{2012}},
}