Elevated pulmonary arterial pressure and altered expression of Ddah1 and Arg1 in mice lacking cavin-1/PTRF.
(2013) In Physiological Reports 1(1). p.00008-00008- Abstract
- Caveolae are invaginations in the plasma membrane that depend on caveolins and cavins for maturation. Here, we investigated the pulmonary phenotype in mice lacking cavin-1. Bright field and electron-microscopy showed that the cavin-1-deficient mice lacked caveolae in the lung, had an increased lung tissue density, and exhibited hypertrophic remodeling of pulmonary arteries. The right ventricle of the heart moreover had an increased mass and the right ventricular pressure was elevated. A microarray analysis revealed upregulation of Arg1 and downregulation of Ddah1, molecules whose altered expression has previously been associated with pulmonary arterial hypertension. Taken together, this work demonstrates vascular remodeling and increased... (More)
- Caveolae are invaginations in the plasma membrane that depend on caveolins and cavins for maturation. Here, we investigated the pulmonary phenotype in mice lacking cavin-1. Bright field and electron-microscopy showed that the cavin-1-deficient mice lacked caveolae in the lung, had an increased lung tissue density, and exhibited hypertrophic remodeling of pulmonary arteries. The right ventricle of the heart moreover had an increased mass and the right ventricular pressure was elevated. A microarray analysis revealed upregulation of Arg1 and downregulation of Ddah1, molecules whose altered expression has previously been associated with pulmonary arterial hypertension. Taken together, this work demonstrates vascular remodeling and increased pulmonary blood pressure in cavin-1 deficient mice and associates this phenotype with altered expression of Arg1 and Ddah1. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4225255
- author
- Swärd, Karl LU ; Karbalaei, Mardjaneh LU ; Mori, Michiko LU ; Erjefält, Jonas LU and Rippe, Catarina LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physiological Reports
- volume
- 1
- issue
- 1
- pages
- 00008 - 00008
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:24303100
- pmid:24303100
- scopus:85009080421
- ISSN
- 2051-817X
- DOI
- 10.1002/PHY2.8
- language
- English
- LU publication?
- yes
- id
- 2c4555fe-8f04-47da-aa8c-75e621e8e1e1 (old id 4225255)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24303100?dopt=Abstract
- date added to LUP
- 2016-04-01 12:56:01
- date last changed
- 2022-01-27 08:23:46
@article{2c4555fe-8f04-47da-aa8c-75e621e8e1e1,
abstract = {{Caveolae are invaginations in the plasma membrane that depend on caveolins and cavins for maturation. Here, we investigated the pulmonary phenotype in mice lacking cavin-1. Bright field and electron-microscopy showed that the cavin-1-deficient mice lacked caveolae in the lung, had an increased lung tissue density, and exhibited hypertrophic remodeling of pulmonary arteries. The right ventricle of the heart moreover had an increased mass and the right ventricular pressure was elevated. A microarray analysis revealed upregulation of Arg1 and downregulation of Ddah1, molecules whose altered expression has previously been associated with pulmonary arterial hypertension. Taken together, this work demonstrates vascular remodeling and increased pulmonary blood pressure in cavin-1 deficient mice and associates this phenotype with altered expression of Arg1 and Ddah1.}},
author = {{Swärd, Karl and Karbalaei, Mardjaneh and Mori, Michiko and Erjefält, Jonas and Rippe, Catarina}},
issn = {{2051-817X}},
language = {{eng}},
number = {{1}},
pages = {{00008--00008}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Physiological Reports}},
title = {{Elevated pulmonary arterial pressure and altered expression of Ddah1 and Arg1 in mice lacking cavin-1/PTRF.}},
url = {{http://dx.doi.org/10.1002/PHY2.8}},
doi = {{10.1002/PHY2.8}},
volume = {{1}},
year = {{2013}},
}