Prediction of good neurological outcome in comatose survivors of cardiac arrest : a systematic review
(2022) In Intensive Care Medicine 48(4). p.389-413- Abstract
Purpose: To assess the ability of clinical examination, blood biomarkers, electrophysiology or neuroimaging assessed within 7 days from return of spontaneous circulation (ROSC) to predict good neurological outcome, defined as no, mild, or moderate disability (CPC 1–2 or mRS 0–3) at discharge from intensive care unit or later, in comatose adult survivors from cardiac arrest (CA). Methods: PubMed, EMBASE, Web of Science and the Cochrane Database of Systematic Reviews were searched. Sensitivity and specificity for good outcome were calculated for each predictor. The risk of bias was assessed using the QUIPS tool. Results: A total of 37 studies were included. Due to heterogeneities in recording times, predictor thresholds, and definition of... (More)
Purpose: To assess the ability of clinical examination, blood biomarkers, electrophysiology or neuroimaging assessed within 7 days from return of spontaneous circulation (ROSC) to predict good neurological outcome, defined as no, mild, or moderate disability (CPC 1–2 or mRS 0–3) at discharge from intensive care unit or later, in comatose adult survivors from cardiac arrest (CA). Methods: PubMed, EMBASE, Web of Science and the Cochrane Database of Systematic Reviews were searched. Sensitivity and specificity for good outcome were calculated for each predictor. The risk of bias was assessed using the QUIPS tool. Results: A total of 37 studies were included. Due to heterogeneities in recording times, predictor thresholds, and definition of some predictors, meta-analysis was not performed. A withdrawal or localisation motor response to pain immediately or at 72–96 h after ROSC, normal blood values of neuron-specific enolase (NSE) at 24 h-72 h after ROSC, a short-latency somatosensory evoked potentials (SSEPs) N20 wave amplitude > 4 µV or a continuous background without discharges on electroencephalogram (EEG) within 72 h from ROSC, and absent diffusion restriction in the cortex or deep grey matter on MRI on days 2–7 after ROSC predicted good neurological outcome with more than 80% specificity and a sensitivity above 40% in most studies. Most studies had moderate or high risk of bias. Conclusions: In comatose cardiac arrest survivors, clinical, biomarker, electrophysiology, and imaging studies identified patients destined to a good neurological outcome with high specificity within the first week after cardiac arrest (CA).
(Less)
- author
- organization
- publishing date
- 2022-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cardiac arrest, Clinical examination, Coma, Computed tomography, Diffusion magnetic resonance imaging, Electroencephalogram, Neuron specific enolase, Prognosis, Somatosensory evoked potentials
- in
- Intensive Care Medicine
- volume
- 48
- issue
- 4
- pages
- 25 pages
- publisher
- Springer
- external identifiers
-
- scopus:85125559412
- pmid:35244745
- ISSN
- 0342-4642
- DOI
- 10.1007/s00134-022-06618-z
- language
- English
- LU publication?
- yes
- id
- 2c56f8a3-c520-44d1-8bf8-ec48e2688613
- date added to LUP
- 2022-04-25 14:56:19
- date last changed
- 2024-06-14 14:45:57
@article{2c56f8a3-c520-44d1-8bf8-ec48e2688613,
abstract = {{<p>Purpose: To assess the ability of clinical examination, blood biomarkers, electrophysiology or neuroimaging assessed within 7 days from return of spontaneous circulation (ROSC) to predict good neurological outcome, defined as no, mild, or moderate disability (CPC 1–2 or mRS 0–3) at discharge from intensive care unit or later, in comatose adult survivors from cardiac arrest (CA). Methods: PubMed, EMBASE, Web of Science and the Cochrane Database of Systematic Reviews were searched. Sensitivity and specificity for good outcome were calculated for each predictor. The risk of bias was assessed using the QUIPS tool. Results: A total of 37 studies were included. Due to heterogeneities in recording times, predictor thresholds, and definition of some predictors, meta-analysis was not performed. A withdrawal or localisation motor response to pain immediately or at 72–96 h after ROSC, normal blood values of neuron-specific enolase (NSE) at 24 h-72 h after ROSC, a short-latency somatosensory evoked potentials (SSEPs) N20 wave amplitude > 4 µV or a continuous background without discharges on electroencephalogram (EEG) within 72 h from ROSC, and absent diffusion restriction in the cortex or deep grey matter on MRI on days 2–7 after ROSC predicted good neurological outcome with more than 80% specificity and a sensitivity above 40% in most studies. Most studies had moderate or high risk of bias. Conclusions: In comatose cardiac arrest survivors, clinical, biomarker, electrophysiology, and imaging studies identified patients destined to a good neurological outcome with high specificity within the first week after cardiac arrest (CA).</p>}},
author = {{Sandroni, Claudio and D’Arrigo, Sonia and Cacciola, Sofia and Hoedemaekers, Cornelia W.E. and Westhall, Erik and Kamps, Marlijn J.A. and Taccone, Fabio S. and Poole, Daniele and Meijer, Frederick J.A. and Antonelli, Massimo and Hirsch, Karen G. and Soar, Jasmeet and Nolan, Jerry P. and Cronberg, Tobias}},
issn = {{0342-4642}},
keywords = {{Cardiac arrest; Clinical examination; Coma; Computed tomography; Diffusion magnetic resonance imaging; Electroencephalogram; Neuron specific enolase; Prognosis; Somatosensory evoked potentials}},
language = {{eng}},
number = {{4}},
pages = {{389--413}},
publisher = {{Springer}},
series = {{Intensive Care Medicine}},
title = {{Prediction of good neurological outcome in comatose survivors of cardiac arrest : a systematic review}},
url = {{http://dx.doi.org/10.1007/s00134-022-06618-z}},
doi = {{10.1007/s00134-022-06618-z}},
volume = {{48}},
year = {{2022}},
}