Effects of a healthy Nordic diet on plasma 25-hydroxyvitamin D concentration in subjects with metabolic syndrome: a randomized, placebo-controlled trial (SYSDIET)

Brader, Lea; Rejnmark, Lars; Carlberg, Carsten; Schwab, Ursula; Kolehmainen, Marjukka; Rosqvist, Fredrik; Cloetens, Lieselotte; Landin-Olsson, Mona; Gunnarsdottir, Ingibjorg; Poutanen, Kaisa S.; Herzig, Karl-Heinz; Riserus, Ulf; Savolainen, Markku J.; Thorsdottir, Inga; Uusitupa, Matti; Hermansen, Kjeld

Effects of a healthy Nordic diet on plasma 25-hydroxyvitamin D concentration in subjects with metabolic syndrome: a randomized, placebo-controlled trial (SYSDIET)

Mark

Brader, Lea ; Rejnmark, Lars ; Carlberg, Carsten ; Schwab, Ursula ; Kolehmainen, Marjukka ; Rosqvist, Fredrik ; Cloetens, Lieselotte ^LU ; Landin-Olsson, Mona ^LU ; Gunnarsdottir, Ingibjorg and Poutanen, Kaisa S. , et al. (2014) In European Journal of Nutrition 53(4). p.1123-1134

Abstract: At northern latitudes, vitamin D is not synthesized endogenously during winter, causing low plasma 25-hydroxyvitamin D (25(OH)D) concentrations. Therefore, we evaluated the effects of a healthy Nordic diet based on Nordic nutrition recommendations (NNR) on plasma 25(OH)D and explored its dietary predictors. In a Nordic multi-centre trial, subjects (n = 213) with metabolic syndrome were randomized to a control or a healthy Nordic diet favouring fish (a parts per thousand yen300 g/week, including a parts per thousand yen200 g/week fatty fish), whole-grain products, berries, fruits, vegetables, rapeseed oil and low-fat dairy products. Plasma 25(OH)D and parathyroid hormone were analysed before and after 18- to 24-week intervention. At... (More); At northern latitudes, vitamin D is not synthesized endogenously during winter, causing low plasma 25-hydroxyvitamin D (25(OH)D) concentrations. Therefore, we evaluated the effects of a healthy Nordic diet based on Nordic nutrition recommendations (NNR) on plasma 25(OH)D and explored its dietary predictors. In a Nordic multi-centre trial, subjects (n = 213) with metabolic syndrome were randomized to a control or a healthy Nordic diet favouring fish (a parts per thousand yen300 g/week, including a parts per thousand yen200 g/week fatty fish), whole-grain products, berries, fruits, vegetables, rapeseed oil and low-fat dairy products. Plasma 25(OH)D and parathyroid hormone were analysed before and after 18- to 24-week intervention. At baseline, 45 % had vitamin D inadequacy (< 50 nmol/l), whereas 8 % had deficiency (< 25 nmol/l). Dietary vitamin D intake was increased by the healthy Nordic diet (P < 0.001). The healthy Nordic and the control diet reduced the prevalence of vitamin D inadequacy by 42 % (P < 0.001) and 19 % (P = 0.002), respectively, without between-group difference (P = 0.142). Compared with control, plasma 25(OH)D (P = 0.208) and parathyroid hormone (P = 0.207) were not altered by the healthy Nordic diet. Predictors for 25(OH)D were intake of vitamin D, eicosapentaenoic acids (EPA), docosahexaenoic acids (DHA), vitamin D supplement, plasma EPA and plasma DHA. Nevertheless, only vitamin D intake and season predicted the 25(OH)D changes. Consuming a healthy Nordic diet based on NNR increased vitamin D intake but not plasma 25(OH)D concentration. The reason why fish consumption did not improve vitamin D status might be that many fish are farmed and might contain little vitamin D or that frying fish may result in vitamin D extraction. Additional ways to improve vitamin D status in Nordic countries may be needed. (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/4552435

author

Brader, Lea ; Rejnmark, Lars ; Carlberg, Carsten ; Schwab, Ursula ; Kolehmainen, Marjukka ; Rosqvist, Fredrik ; Cloetens, Lieselotte ^LU ; Landin-Olsson, Mona ^LU ; Gunnarsdottir, Ingibjorg and Poutanen, Kaisa S. , et al. (More)

Brader, Lea ; Rejnmark, Lars ; Carlberg, Carsten ; Schwab, Ursula ; Kolehmainen, Marjukka ; Rosqvist, Fredrik ; Cloetens, Lieselotte ^LU ; Landin-Olsson, Mona ^LU ; Gunnarsdottir, Ingibjorg ; Poutanen, Kaisa S. ; Herzig, Karl-Heinz ; Riserus, Ulf ; Savolainen, Markku J. ; Thorsdottir, Inga ; Uusitupa, Matti and Hermansen, Kjeld (Less)

organization

publishing date

2014

type

Contribution to journal

publication status

published

subject

Nutrition and Dietetics

keywords

Vitamin D, 25-hydroxyvitamin D, Healthy Nordic diet, Nordic nutrition, recommendations, Metabolic syndrome

in

European Journal of Nutrition

volume

53

issue

4

pages

1123 - 1134

publisher

Springer

external identifiers

wos:000336801700012
scopus:84903448252
pmid:24570029

ISSN

1436-6215

DOI

10.1007/s00394-014-0674-3

language

English

LU publication?

yes

id

2d079190-3229-4202-b4da-07c241b4f06d (old id 4552435)

date added to LUP

2016-04-01 09:54:10

date last changed

2024-01-06 02:42:45

@article{2d079190-3229-4202-b4da-07c241b4f06d,
  abstract     = {{At northern latitudes, vitamin D is not synthesized endogenously during winter, causing low plasma 25-hydroxyvitamin D (25(OH)D) concentrations. Therefore, we evaluated the effects of a healthy Nordic diet based on Nordic nutrition recommendations (NNR) on plasma 25(OH)D and explored its dietary predictors. In a Nordic multi-centre trial, subjects (n = 213) with metabolic syndrome were randomized to a control or a healthy Nordic diet favouring fish (a parts per thousand yen300 g/week, including a parts per thousand yen200 g/week fatty fish), whole-grain products, berries, fruits, vegetables, rapeseed oil and low-fat dairy products. Plasma 25(OH)D and parathyroid hormone were analysed before and after 18- to 24-week intervention. At baseline, 45 % had vitamin D inadequacy (&lt; 50 nmol/l), whereas 8 % had deficiency (&lt; 25 nmol/l). Dietary vitamin D intake was increased by the healthy Nordic diet (P &lt; 0.001). The healthy Nordic and the control diet reduced the prevalence of vitamin D inadequacy by 42 % (P &lt; 0.001) and 19 % (P = 0.002), respectively, without between-group difference (P = 0.142). Compared with control, plasma 25(OH)D (P = 0.208) and parathyroid hormone (P = 0.207) were not altered by the healthy Nordic diet. Predictors for 25(OH)D were intake of vitamin D, eicosapentaenoic acids (EPA), docosahexaenoic acids (DHA), vitamin D supplement, plasma EPA and plasma DHA. Nevertheless, only vitamin D intake and season predicted the 25(OH)D changes. Consuming a healthy Nordic diet based on NNR increased vitamin D intake but not plasma 25(OH)D concentration. The reason why fish consumption did not improve vitamin D status might be that many fish are farmed and might contain little vitamin D or that frying fish may result in vitamin D extraction. Additional ways to improve vitamin D status in Nordic countries may be needed.}},
  author       = {{Brader, Lea and Rejnmark, Lars and Carlberg, Carsten and Schwab, Ursula and Kolehmainen, Marjukka and Rosqvist, Fredrik and Cloetens, Lieselotte and Landin-Olsson, Mona and Gunnarsdottir, Ingibjorg and Poutanen, Kaisa S. and Herzig, Karl-Heinz and Riserus, Ulf and Savolainen, Markku J. and Thorsdottir, Inga and Uusitupa, Matti and Hermansen, Kjeld}},
  issn         = {{1436-6215}},
  keywords     = {{Vitamin D; 25-hydroxyvitamin D; Healthy Nordic diet; Nordic nutrition; recommendations; Metabolic syndrome}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{1123--1134}},
  publisher    = {{Springer}},
  series       = {{European Journal of Nutrition}},
  title        = {{Effects of a healthy Nordic diet on plasma 25-hydroxyvitamin D concentration in subjects with metabolic syndrome: a randomized, placebo-controlled trial (SYSDIET)}},
  url          = {{http://dx.doi.org/10.1007/s00394-014-0674-3}},
  doi          = {{10.1007/s00394-014-0674-3}},
  volume       = {{53}},
  year         = {{2014}},
}

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Effects of a healthy Nordic diet on plasma 25-hydroxyvitamin D concentration in subjects with metabolic syndrome: a randomized, placebo-controlled trial (SYSDIET)