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Overexpressing Cu/Zn superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease

Nakao, Naoyuki; Frodl, Eva M; Widner, H LU ; Carlson, E; Eggerding, F A; Epstein, C J and Brundin, P LU (1995) In Nature Medicine 1(3). p.31-226
Abstract

A high survival rate of grafted dopamine neurons is crucial for reversing neurological deficits following brain tissue transplantation in Parkinson's disease. For unknown reasons the survival rate of transplanted dopamine neurons is only around 10% in experimental animals. The hypothesis that oxidative stress causes the loss of transplanted neurons was tested by grafting neurons from transgenic mice that overexpress Cu/Zn superoxide dismutase. Compared with the survival of those taken from non-transgenic littermates, the survival was 4 times higher for the transgenic dopamine neurons with a concomitant more extensive functional recovery. The results provide direct support for the free radical hypothesis of dopaminergic neuron death in... (More)

A high survival rate of grafted dopamine neurons is crucial for reversing neurological deficits following brain tissue transplantation in Parkinson's disease. For unknown reasons the survival rate of transplanted dopamine neurons is only around 10% in experimental animals. The hypothesis that oxidative stress causes the loss of transplanted neurons was tested by grafting neurons from transgenic mice that overexpress Cu/Zn superoxide dismutase. Compared with the survival of those taken from non-transgenic littermates, the survival was 4 times higher for the transgenic dopamine neurons with a concomitant more extensive functional recovery. The results provide direct support for the free radical hypothesis of dopaminergic neuron death in brain tissue grafting.

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keywords
Amphetamines, Animals, Disease Models, Animal, Female, Gene Expression, Graft Survival, Mesencephalon, Mice, Mice, Transgenic, Parkinson Disease, RNA, Messenger, Rats, Rats, Sprague-Dawley, Stereotyped Behavior, Substantia Nigra, Superoxide Dismutase, Transplantation, Heterologous, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
in
Nature Medicine
volume
1
issue
3
pages
6 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:0028899401
ISSN
1078-8956
language
English
LU publication?
yes
id
2d32f92d-7d8d-4677-b8f1-5b4effbbe110
date added to LUP
2017-04-19 18:26:49
date last changed
2017-10-29 05:00:34
@article{2d32f92d-7d8d-4677-b8f1-5b4effbbe110,
  abstract     = {<p>A high survival rate of grafted dopamine neurons is crucial for reversing neurological deficits following brain tissue transplantation in Parkinson's disease. For unknown reasons the survival rate of transplanted dopamine neurons is only around 10% in experimental animals. The hypothesis that oxidative stress causes the loss of transplanted neurons was tested by grafting neurons from transgenic mice that overexpress Cu/Zn superoxide dismutase. Compared with the survival of those taken from non-transgenic littermates, the survival was 4 times higher for the transgenic dopamine neurons with a concomitant more extensive functional recovery. The results provide direct support for the free radical hypothesis of dopaminergic neuron death in brain tissue grafting.</p>},
  author       = {Nakao, Naoyuki and Frodl, Eva M and Widner, H and Carlson, E and Eggerding, F A and Epstein, C J and Brundin, P},
  issn         = {1078-8956},
  keyword      = {Amphetamines,Animals,Disease Models, Animal,Female,Gene Expression,Graft Survival,Mesencephalon,Mice,Mice, Transgenic,Parkinson Disease,RNA, Messenger,Rats,Rats, Sprague-Dawley,Stereotyped Behavior,Substantia Nigra,Superoxide Dismutase,Transplantation, Heterologous,Research Support, Non-U.S. Gov't,Research Support, U.S. Gov't, P.H.S.},
  language     = {eng},
  number       = {3},
  pages        = {31--226},
  publisher    = {Nature Publishing Group},
  series       = {Nature Medicine},
  title        = {Overexpressing Cu/Zn superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease},
  volume       = {1},
  year         = {1995},
}