Overexpressing Cu/Zn superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease
(1995) In Nature Medicine 1(3). p.31-226- Abstract
A high survival rate of grafted dopamine neurons is crucial for reversing neurological deficits following brain tissue transplantation in Parkinson's disease. For unknown reasons the survival rate of transplanted dopamine neurons is only around 10% in experimental animals. The hypothesis that oxidative stress causes the loss of transplanted neurons was tested by grafting neurons from transgenic mice that overexpress Cu/Zn superoxide dismutase. Compared with the survival of those taken from non-transgenic littermates, the survival was 4 times higher for the transgenic dopamine neurons with a concomitant more extensive functional recovery. The results provide direct support for the free radical hypothesis of dopaminergic neuron death in... (More)
A high survival rate of grafted dopamine neurons is crucial for reversing neurological deficits following brain tissue transplantation in Parkinson's disease. For unknown reasons the survival rate of transplanted dopamine neurons is only around 10% in experimental animals. The hypothesis that oxidative stress causes the loss of transplanted neurons was tested by grafting neurons from transgenic mice that overexpress Cu/Zn superoxide dismutase. Compared with the survival of those taken from non-transgenic littermates, the survival was 4 times higher for the transgenic dopamine neurons with a concomitant more extensive functional recovery. The results provide direct support for the free radical hypothesis of dopaminergic neuron death in brain tissue grafting.
(Less)
- author
- Nakao, Naoyuki ; Frodl, Eva M ; Widner, H LU ; Carlson, E ; Eggerding, F A ; Epstein, C J and Brundin, P LU
- organization
- publishing date
- 1995-03
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Amphetamines, Animals, Disease Models, Animal, Female, Gene Expression, Graft Survival, Mesencephalon, Mice, Mice, Transgenic, Parkinson Disease, RNA, Messenger, Rats, Rats, Sprague-Dawley, Stereotyped Behavior, Substantia Nigra, Superoxide Dismutase, Transplantation, Heterologous, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
- in
- Nature Medicine
- volume
- 1
- issue
- 3
- pages
- 6 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:0028899401
- pmid:7585038
- ISSN
- 1078-8956
- language
- English
- LU publication?
- yes
- id
- 2d32f92d-7d8d-4677-b8f1-5b4effbbe110
- date added to LUP
- 2017-04-19 18:26:49
- date last changed
- 2024-03-17 10:30:34
@article{2d32f92d-7d8d-4677-b8f1-5b4effbbe110,
abstract = {{<p>A high survival rate of grafted dopamine neurons is crucial for reversing neurological deficits following brain tissue transplantation in Parkinson's disease. For unknown reasons the survival rate of transplanted dopamine neurons is only around 10% in experimental animals. The hypothesis that oxidative stress causes the loss of transplanted neurons was tested by grafting neurons from transgenic mice that overexpress Cu/Zn superoxide dismutase. Compared with the survival of those taken from non-transgenic littermates, the survival was 4 times higher for the transgenic dopamine neurons with a concomitant more extensive functional recovery. The results provide direct support for the free radical hypothesis of dopaminergic neuron death in brain tissue grafting.</p>}},
author = {{Nakao, Naoyuki and Frodl, Eva M and Widner, H and Carlson, E and Eggerding, F A and Epstein, C J and Brundin, P}},
issn = {{1078-8956}},
keywords = {{Amphetamines; Animals; Disease Models, Animal; Female; Gene Expression; Graft Survival; Mesencephalon; Mice; Mice, Transgenic; Parkinson Disease; RNA, Messenger; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Substantia Nigra; Superoxide Dismutase; Transplantation, Heterologous; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.}},
language = {{eng}},
number = {{3}},
pages = {{31--226}},
publisher = {{Nature Publishing Group}},
series = {{Nature Medicine}},
title = {{Overexpressing Cu/Zn superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease}},
volume = {{1}},
year = {{1995}},
}