Extracellular vesicles in renal inflammatory and infectious diseases
Karpman, Diana LU
and Tontanahal, Ashmita
LU
(2021)
In Free Radical Biology and Medicine
171.
p.42-54
- Abstract
Extracellular vesicles can mediate cell-to-cell communication, or relieve the parent cell of harmful substances, in order to maintain cellular integrity. The content of extracellular vesicles includes miRNAs, mRNAs, growth factors, complement factors, cytokines, chemokines and receptors. These may contribute to inflammatory and infectious diseases by the exposure or transfer of potent effectors that induce vascular inflammation by leukocyte recruitment and thrombosis. Furthermore, vesicles release cytokines and induce their release from cells. Extracellular vesicles possess immune modulatory and anti-microbial properties, and induce receptor signaling in the recipient cell, not least by the transfer of pro-inflammatory receptors.... (More)
Extracellular vesicles can mediate cell-to-cell communication, or relieve the parent cell of harmful substances, in order to maintain cellular integrity. The content of extracellular vesicles includes miRNAs, mRNAs, growth factors, complement factors, cytokines, chemokines and receptors. These may contribute to inflammatory and infectious diseases by the exposure or transfer of potent effectors that induce vascular inflammation by leukocyte recruitment and thrombosis. Furthermore, vesicles release cytokines and induce their release from cells. Extracellular vesicles possess immune modulatory and anti-microbial properties, and induce receptor signaling in the recipient cell, not least by the transfer of pro-inflammatory receptors. Additionally, the vesicles may carry virulence factors systemically. Extracellular vesicles in blood and urine can contribute to the development of kidney diseases or exhibit protective effects. In this review we will describe the role of EVs in inflammation, thrombosis, immune modulation, angiogenesis, oxidative stress, renal tubular regeneration and infection. Furthermore, we will delineate their contribution to renal ischemia/reperfusion, vasculitis, glomerulonephritis, lupus nephritis, thrombotic microangiopathies, IgA nephropathy, acute kidney injury, urinary tract infections and renal transplantation. Due to their content of miRNAs and growth factors, or when loaded with nephroprotective modulators, extracellular vesicles have the potential to be used as therapeutics for renal regeneration.
(Less)
- author
- Karpman, Diana
LU
and Tontanahal, Ashmita
LU
- organization
- publishing date
- 2021-08-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Extracellular vesicles, Inflammation, Kidney, Shiga toxin, Complement, Thrombosis, Vasculitis
- in
- Free Radical Biology and Medicine
- volume
- 171
- pages
- 13 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:33933600
- scopus:85105592380
- ISSN
- 0891-5849
- DOI
- 10.1016/j.freeradbiomed.2021.04.032
- language
- English
- LU publication?
- yes
- id
- 2e409bfe-1dfd-4ab4-9970-e6b8d0228831
- date added to LUP
- 2021-05-26 16:19:10
- date last changed
- 2024-04-20 06:31:12
@article{2e409bfe-1dfd-4ab4-9970-e6b8d0228831,
abstract = {{<p>Extracellular vesicles can mediate cell-to-cell communication, or relieve the parent cell of harmful substances, in order to maintain cellular integrity. The content of extracellular vesicles includes miRNAs, mRNAs, growth factors, complement factors, cytokines, chemokines and receptors. These may contribute to inflammatory and infectious diseases by the exposure or transfer of potent effectors that induce vascular inflammation by leukocyte recruitment and thrombosis. Furthermore, vesicles release cytokines and induce their release from cells. Extracellular vesicles possess immune modulatory and anti-microbial properties, and induce receptor signaling in the recipient cell, not least by the transfer of pro-inflammatory receptors. Additionally, the vesicles may carry virulence factors systemically. Extracellular vesicles in blood and urine can contribute to the development of kidney diseases or exhibit protective effects. In this review we will describe the role of EVs in inflammation, thrombosis, immune modulation, angiogenesis, oxidative stress, renal tubular regeneration and infection. Furthermore, we will delineate their contribution to renal ischemia/reperfusion, vasculitis, glomerulonephritis, lupus nephritis, thrombotic microangiopathies, IgA nephropathy, acute kidney injury, urinary tract infections and renal transplantation. Due to their content of miRNAs and growth factors, or when loaded with nephroprotective modulators, extracellular vesicles have the potential to be used as therapeutics for renal regeneration.</p>}},
author = {{Karpman, Diana and Tontanahal, Ashmita}},
issn = {{0891-5849}},
keywords = {{Extracellular vesicles; Inflammation; Kidney; Shiga toxin, Complement; Thrombosis; Vasculitis}},
language = {{eng}},
month = {{08}},
pages = {{42--54}},
publisher = {{Elsevier}},
series = {{Free Radical Biology and Medicine}},
title = {{Extracellular vesicles in renal inflammatory and infectious diseases}},
url = {{http://dx.doi.org/10.1016/j.freeradbiomed.2021.04.032}},
doi = {{10.1016/j.freeradbiomed.2021.04.032}},
volume = {{171}},
year = {{2021}},
}