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Dacrymenone and VM 3298-2 - New antibiotics with antibacterial and antifungal activity

Mierau, V; Anke, T and Sterner, Olov LU (2003) In Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences 58(7-8). p.541-546
Abstract
Two new antibiotic metabolites, dacrymenone (1) and VM 3298-2 (2), were isolated from fermentations of a Dacrymyces sp., and their structures were determined by spectroscopic techniques. Dacrymenone (1) is a new eremophilane sesquiterpenoid while VM 3298-2 (2) is a bis-enol ether between methyl pyruvate and 4,6-dihydroxycyclohexan-1,3-dione. Dacrymenone (1) shows weak antibacterial and antifungal activity while VM 3298-2 (2) exhibits cytotoxic and antifungal activities.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
antifungal antibiotic, eremophilanes, Dacrymyces
in
Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences
volume
58
issue
7-8
pages
541 - 546
publisher
Verlag der Zeitschrift für Naturforschung
external identifiers
  • wos:000185144500016
  • scopus:0041655935
ISSN
0939-5075
language
English
LU publication?
yes
id
79c8a573-b467-41d7-8e67-9391fad9747e (old id 301538)
alternative location
http://www.znaturforsch.com/ac/v58c/s58c0541.pdf
date added to LUP
2007-09-18 12:37:07
date last changed
2018-01-07 09:02:57
@article{79c8a573-b467-41d7-8e67-9391fad9747e,
  abstract     = {Two new antibiotic metabolites, dacrymenone (1) and VM 3298-2 (2), were isolated from fermentations of a Dacrymyces sp., and their structures were determined by spectroscopic techniques. Dacrymenone (1) is a new eremophilane sesquiterpenoid while VM 3298-2 (2) is a bis-enol ether between methyl pyruvate and 4,6-dihydroxycyclohexan-1,3-dione. Dacrymenone (1) shows weak antibacterial and antifungal activity while VM 3298-2 (2) exhibits cytotoxic and antifungal activities.},
  author       = {Mierau, V and Anke, T and Sterner, Olov},
  issn         = {0939-5075},
  keyword      = {antifungal antibiotic,eremophilanes,Dacrymyces},
  language     = {eng},
  number       = {7-8},
  pages        = {541--546},
  publisher    = {Verlag der Zeitschrift für Naturforschung},
  series       = {Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences},
  title        = {Dacrymenone and VM 3298-2 - New antibiotics with antibacterial and antifungal activity},
  volume       = {58},
  year         = {2003},
}