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Kindling alters entorhinal cortex-hippocampal interaction by increased efficacy of presynaptic GABA(B) autoreceptors in layer III of the entorhinal cortex

Gloveli, T; Behr, J; Dugladze, T; Kokaia, Zaal LU ; Kokaia, Merab LU and Heinemann, U (2003) In Neurobiology of Disease 13(3). p.203-212
Abstract
We studied the effect of kindling, a model of temporal lobe epilepsy, on the frequency-dependent information transfer from the entorhinal cortex to the hippocampus in vitro. In control rats repetitive synaptic activation of layer III projection cells resulted in a frequency dependent depression of the synaptic transfer of action potentials to the hippocampus. One-to-two-days after kindling this effect was strongly reduced. Although no substantial change in synaptic inhibition upon single electrical stimulation was detected in kindled rats, there was a significant depression in the prolonged inhibition following high frequency stimulation. In kindled animals, paired-pulse depression (PPD) of stimulus-evoked IPSCs in layer III neurons was... (More)
We studied the effect of kindling, a model of temporal lobe epilepsy, on the frequency-dependent information transfer from the entorhinal cortex to the hippocampus in vitro. In control rats repetitive synaptic activation of layer III projection cells resulted in a frequency dependent depression of the synaptic transfer of action potentials to the hippocampus. One-to-two-days after kindling this effect was strongly reduced. Although no substantial change in synaptic inhibition upon single electrical stimulation was detected in kindled rats, there was a significant depression in the prolonged inhibition following high frequency stimulation. In kindled animals, paired-pulse depression (PPD) of stimulus-evoked IPSCs in layer III neurons was significantly stronger than in control rats. The increase of PPD is most likely caused by an increased presynaptic GABA(B) receptor-mediated autoinhibition. In kindled animals activation of presynaptic GABA(B) receptors by baclofen (10 muM) suppressed monosynaptic IPSCs significantly more than in control rats. In contrast, activation of postsynaptic GABA(B) receptors by baclofen was accompanied by comparable changes of the membrane conductance in both animal groups. Thus, in kindled animals activation of the layer III-CA1 pathway is facilitated by an increased GABA(B) receptor-mediated autoinhibition leading to an enhanced activation of the monosynaptic EC-CA1 pathway. (C) 2003 Elsevier Science (USA). All rights reserved. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
keywords
synaptic, GABA(B), kindling, projection cells, intracellular recording, transmission, in vitro, rats
in
Neurobiology of Disease
volume
13
issue
3
pages
203 - 212
publisher
Elsevier
external identifiers
  • wos:000184559400003
  • pmid:12901834
  • scopus:0041592480
ISSN
0969-9961
DOI
language
English
LU publication?
yes
id
3810f5ec-4dd0-477c-a23a-d639e27b7909 (old id 304274)
date added to LUP
2007-09-03 11:12:18
date last changed
2018-05-29 12:05:45
@article{3810f5ec-4dd0-477c-a23a-d639e27b7909,
  abstract     = {We studied the effect of kindling, a model of temporal lobe epilepsy, on the frequency-dependent information transfer from the entorhinal cortex to the hippocampus in vitro. In control rats repetitive synaptic activation of layer III projection cells resulted in a frequency dependent depression of the synaptic transfer of action potentials to the hippocampus. One-to-two-days after kindling this effect was strongly reduced. Although no substantial change in synaptic inhibition upon single electrical stimulation was detected in kindled rats, there was a significant depression in the prolonged inhibition following high frequency stimulation. In kindled animals, paired-pulse depression (PPD) of stimulus-evoked IPSCs in layer III neurons was significantly stronger than in control rats. The increase of PPD is most likely caused by an increased presynaptic GABA(B) receptor-mediated autoinhibition. In kindled animals activation of presynaptic GABA(B) receptors by baclofen (10 muM) suppressed monosynaptic IPSCs significantly more than in control rats. In contrast, activation of postsynaptic GABA(B) receptors by baclofen was accompanied by comparable changes of the membrane conductance in both animal groups. Thus, in kindled animals activation of the layer III-CA1 pathway is facilitated by an increased GABA(B) receptor-mediated autoinhibition leading to an enhanced activation of the monosynaptic EC-CA1 pathway. (C) 2003 Elsevier Science (USA). All rights reserved.},
  author       = {Gloveli, T and Behr, J and Dugladze, T and Kokaia, Zaal and Kokaia, Merab and Heinemann, U},
  issn         = {0969-9961},
  keyword      = {synaptic,GABA(B),kindling,projection cells,intracellular recording,transmission,in vitro,rats},
  language     = {eng},
  number       = {3},
  pages        = {203--212},
  publisher    = {Elsevier},
  series       = {Neurobiology of Disease},
  title        = {Kindling alters entorhinal cortex-hippocampal interaction by increased efficacy of presynaptic GABA(B) autoreceptors in layer III of the entorhinal cortex},
  url          = {http://dx.doi.org/},
  volume       = {13},
  year         = {2003},
}