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Familial risks of psychotic disorders and schizophrenia among siblings based on hospitalizations in Sweden

Li, Xinjun LU ; Sundquist, Jan LU ; Hemminki, Kari LU and Sundquist, Kristina LU (2009) In Psychiatry Research 166(1). p.1-6
Abstract

Familial risks of psychotic disorders and schizophrenia have been assessed in previous studies. However, the degree of familial clustering in large population datasets remains to be established. We conducted a study on familial risks of psychotic disorders and schizophrenia by linking the Multigeneration Register to the nationwide Swedish Hospital Discharge Register. All patients younger than 72 years hospitalized for psychotic disorders or schizophrenia between 1987 and 2004 were included. Standardized incidence ratios (SIRs) were calculated for individuals with affected singleton siblings, twins or spouses compared with individuals whose siblings or spouses had no hospitalization for psychotic disorders or schizophrenia. A total of... (More)

Familial risks of psychotic disorders and schizophrenia have been assessed in previous studies. However, the degree of familial clustering in large population datasets remains to be established. We conducted a study on familial risks of psychotic disorders and schizophrenia by linking the Multigeneration Register to the nationwide Swedish Hospital Discharge Register. All patients younger than 72 years hospitalized for psychotic disorders or schizophrenia between 1987 and 2004 were included. Standardized incidence ratios (SIRs) were calculated for individuals with affected singleton siblings, twins or spouses compared with individuals whose siblings or spouses had no hospitalization for psychotic disorders or schizophrenia. A total of 40,228 hospitalized cases were identified of which 3006 were affected sibling pairs. The overall significant familial SIRs were 4.82 for psychotic disorders and 7.34 for schizophrenia. The highest SIRs were found in the younger ages. There were no significant gender differences. The significant SIR for psychotic disorders among twin pairs was 6.40 and the significant SIRs for psychotic disorders among spouses varied between 3.17 and 3.29. Age difference between siblings had no effect on the magnitude of the SIRs. The findings of the present large-scale study suggest that heritable factors have a stronger effect on psychotic disorders and schizophrenia than environmental factors. Future studies could coordinate epidemiological studies of large populations with molecular biology resources.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Adult, Age Factors, Aged, Cross-Sectional Studies, Female, Genetic Predisposition to Disease/genetics, Hospitalization/statistics & numerical data, Humans, Incidence, Male, Middle Aged, Psychotic Disorders/epidemiology, Registries, Schizophrenia/epidemiology, Sex Factors, Siblings, Social Environment, Sweden, Young Adult
in
Psychiatry Research
volume
166
issue
1
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:60349126520
ISSN
0165-1781
DOI
10.1016/j.psychres.2007.12.003
language
English
LU publication?
no
id
3065fa7d-acfd-449e-bf9b-922c46810fbc
date added to LUP
2019-01-30 10:54:25
date last changed
2019-03-08 02:19:34
@article{3065fa7d-acfd-449e-bf9b-922c46810fbc,
  abstract     = {<p>Familial risks of psychotic disorders and schizophrenia have been assessed in previous studies. However, the degree of familial clustering in large population datasets remains to be established. We conducted a study on familial risks of psychotic disorders and schizophrenia by linking the Multigeneration Register to the nationwide Swedish Hospital Discharge Register. All patients younger than 72 years hospitalized for psychotic disorders or schizophrenia between 1987 and 2004 were included. Standardized incidence ratios (SIRs) were calculated for individuals with affected singleton siblings, twins or spouses compared with individuals whose siblings or spouses had no hospitalization for psychotic disorders or schizophrenia. A total of 40,228 hospitalized cases were identified of which 3006 were affected sibling pairs. The overall significant familial SIRs were 4.82 for psychotic disorders and 7.34 for schizophrenia. The highest SIRs were found in the younger ages. There were no significant gender differences. The significant SIR for psychotic disorders among twin pairs was 6.40 and the significant SIRs for psychotic disorders among spouses varied between 3.17 and 3.29. Age difference between siblings had no effect on the magnitude of the SIRs. The findings of the present large-scale study suggest that heritable factors have a stronger effect on psychotic disorders and schizophrenia than environmental factors. Future studies could coordinate epidemiological studies of large populations with molecular biology resources.</p>},
  author       = {Li, Xinjun and Sundquist, Jan and Hemminki, Kari and Sundquist, Kristina},
  issn         = {0165-1781},
  keyword      = {Adult,Age Factors,Aged,Cross-Sectional Studies,Female,Genetic Predisposition to Disease/genetics,Hospitalization/statistics & numerical data,Humans,Incidence,Male,Middle Aged,Psychotic Disorders/epidemiology,Registries,Schizophrenia/epidemiology,Sex Factors,Siblings,Social Environment,Sweden,Young Adult},
  language     = {eng},
  month        = {03},
  number       = {1},
  pages        = {1--6},
  publisher    = {Elsevier},
  series       = {Psychiatry Research},
  title        = {Familial risks of psychotic disorders and schizophrenia among siblings based on hospitalizations in Sweden},
  url          = {http://dx.doi.org/10.1016/j.psychres.2007.12.003},
  volume       = {166},
  year         = {2009},
}