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Dietary intake of iron, heme-iron and magnesium and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort

Molina-Montes, Esther; Wark, Petra A.; Sanchez, Maria-Jose; Norat, Teresa; Jakszyn, Paula; Lujan-Barroso, Leila; Michaud, Dominique S.; Crowe, Francesca; Allen, Naomi and Khaw, Kay-Tee, et al. (2012) In International Journal of Cancer 131(7). p.1134-1147
Abstract
Several studies support a protective effect of dietary magnesium against type 2 diabetes, but a harmful effect for iron. As diabetes has been linked to pancreatic cancer, intake of these nutrients may be also associated with this cancer. We examined the association between dietary intake of magnesium, total iron and heme-iron and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. In total, 142,203 men and 334,999 women, recruited between 1992 and 2000, were included. After an average follow-up of 11.3 years, 396 men and 469 women developed exocrine pancreatic cancer. Hazard ratios and 95% confidence intervals (CIs) were obtained using Cox regression stratified by age and center, and... (More)
Several studies support a protective effect of dietary magnesium against type 2 diabetes, but a harmful effect for iron. As diabetes has been linked to pancreatic cancer, intake of these nutrients may be also associated with this cancer. We examined the association between dietary intake of magnesium, total iron and heme-iron and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. In total, 142,203 men and 334,999 women, recruited between 1992 and 2000, were included. After an average follow-up of 11.3 years, 396 men and 469 women developed exocrine pancreatic cancer. Hazard ratios and 95% confidence intervals (CIs) were obtained using Cox regression stratified by age and center, and adjusted for energy intake, smoking status, height, weight, and self-reported diabetes status. Neither intake of magnesium, total iron nor heme-iron was associated with pancreatic cancer risk. In stratified analyses, a borderline inverse association was observed among overweight men (body mass index, =25 kg/m2) with magnesium (HRper 100 mg/day increase = 0.79, 95% CI = 0.631.01) although this was less apparent using calibrated intake. In female smokers, a higher intake of heme-iron was associated with a higher pancreatic cancer risk (HR per 1 mg/day increase = 1.38, 95% CI = 1.101.74). After calibration, this risk increased significantly to 2.5-fold (95% CI = 1.225.28). Overall, dietary magnesium, total iron and heme-iron were not associated with pancreatic cancer risk during the follow-up period. Our observation that heme-iron was associated with increased pancreatic cancer risk in female smokers warrants replication in additional study populations. (Less)
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publication status
published
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keywords
diet, magnesium, iron, nutrients, pancreatic cancer, cohort, epidemiology
in
International Journal of Cancer
volume
131
issue
7
pages
1134 - 1147
publisher
John Wiley & Sons
external identifiers
  • wos:000306915700009
  • scopus:84864439756
ISSN
0020-7136
DOI
10.1002/ijc.27547
language
English
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yes
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2051cdbb-4af9-4037-a938-a0429ce782a1 (old id 3073460)
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2012-10-05 07:14:01
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2017-01-29 03:16:46
@article{2051cdbb-4af9-4037-a938-a0429ce782a1,
  abstract     = {Several studies support a protective effect of dietary magnesium against type 2 diabetes, but a harmful effect for iron. As diabetes has been linked to pancreatic cancer, intake of these nutrients may be also associated with this cancer. We examined the association between dietary intake of magnesium, total iron and heme-iron and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. In total, 142,203 men and 334,999 women, recruited between 1992 and 2000, were included. After an average follow-up of 11.3 years, 396 men and 469 women developed exocrine pancreatic cancer. Hazard ratios and 95% confidence intervals (CIs) were obtained using Cox regression stratified by age and center, and adjusted for energy intake, smoking status, height, weight, and self-reported diabetes status. Neither intake of magnesium, total iron nor heme-iron was associated with pancreatic cancer risk. In stratified analyses, a borderline inverse association was observed among overweight men (body mass index, =25 kg/m2) with magnesium (HRper 100 mg/day increase = 0.79, 95% CI = 0.631.01) although this was less apparent using calibrated intake. In female smokers, a higher intake of heme-iron was associated with a higher pancreatic cancer risk (HR per 1 mg/day increase = 1.38, 95% CI = 1.101.74). After calibration, this risk increased significantly to 2.5-fold (95% CI = 1.225.28). Overall, dietary magnesium, total iron and heme-iron were not associated with pancreatic cancer risk during the follow-up period. Our observation that heme-iron was associated with increased pancreatic cancer risk in female smokers warrants replication in additional study populations.},
  author       = {Molina-Montes, Esther and Wark, Petra A. and Sanchez, Maria-Jose and Norat, Teresa and Jakszyn, Paula and Lujan-Barroso, Leila and Michaud, Dominique S. and Crowe, Francesca and Allen, Naomi and Khaw, Kay-Tee and Wareham, Nicholas and Trichopoulou, Antonia and Adarakis, George and Katarachia, Helen and Skeie, Guri and Henningsen, Maria and Broderstad, Ann Ragnhild and Berrino, Franco and Tumino, Rosario and Palli, Domenico and Mattiello, Amalia and Vineis, Paolo and Amiano, Pilar and Barricarte, Aurelio and Huerta, Jose-Maria and Duell, Eric J. and Quiros, Jose-Ramon and Ye, Weimin and Sund, Malin and Lindkvist, Bjorn and Johansen, Dorthe and Overvad, Kim and Tjonneland, Anne and Roswall, Nina and Li, Kuanrong and Grote, Verena A. and Steffen, Annika and Boeing, Heiner and Racine, Antoine and Boutron-Ruault, Marie-Christine and Carbonnel, Franck and Peeters, Petra H. M. and Siersema, Peter D. and Fedirko, Veronika and Jenab, Mazda and Riboli, Elio and Bueno-de-Mesquita, Bas},
  issn         = {0020-7136},
  keyword      = {diet,magnesium,iron,nutrients,pancreatic cancer,cohort,epidemiology},
  language     = {eng},
  number       = {7},
  pages        = {1134--1147},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Dietary intake of iron, heme-iron and magnesium and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort},
  url          = {http://dx.doi.org/10.1002/ijc.27547},
  volume       = {131},
  year         = {2012},
}