Oat Bran Increased Fecal Butyrate and Prevented Gastrointestinal Symptoms in Patients With Quiescent Ulcerative Colitis—Randomized Controlled Trial
(2020) In Crohns & Colitis 360 2(1).- Abstract
- Background
Oat bran specifically increases colon butyrate concentrations and could therefore affect the progress of the disease in patients with ulcerative colitis (UC).
Methods
Patients with UC in remission were enrolled in a controlled multicenter study and randomized to eat oat bran or low-fiber wheat products.
Results
Ninety-four of the enrolled patients (n = 47 for both groups) completed the 24-week study. The oat bran group had significantly (P < 0.05) higher fecal butyrate concentrations and lower serum LDL levels, while deterioration of gastrointestinal symptoms was prevented, and subjective health maintained. The control diet significantly (P < 0.05) increased obstipation, reflux, and the symptom burden... (More) - Background
Oat bran specifically increases colon butyrate concentrations and could therefore affect the progress of the disease in patients with ulcerative colitis (UC).
Methods
Patients with UC in remission were enrolled in a controlled multicenter study and randomized to eat oat bran or low-fiber wheat products.
Results
Ninety-four of the enrolled patients (n = 47 for both groups) completed the 24-week study. The oat bran group had significantly (P < 0.05) higher fecal butyrate concentrations and lower serum LDL levels, while deterioration of gastrointestinal symptoms was prevented, and subjective health maintained. The control diet significantly (P < 0.05) increased obstipation, reflux, and the symptom burden and had no effects on butyrate or LDL-cholesterol. The relapse rate was the same for both diets.
Conclusions
Oat bran was well tolerated when given to patients with quiescent UC. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/30861c08-9ece-4a4b-a6b0-5baab5ab169f
- author
- Nyman, Margareta LU ; Nguyen, Thao Duy LU ; Wikman, Ola ; Hjortswang, Henrik and Hallert, C
- organization
- publishing date
- 2020-01-16
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ulcerative colitis, β-glucan, oat bran, butyrate
- in
- Crohns & Colitis 360
- volume
- 2
- issue
- 1
- article number
- 2
- pages
- 13 pages
- publisher
- Oxford University Press
- external identifiers
-
- scopus:85103804783
- ISSN
- 2631-827X
- DOI
- 10.1093/crocol/otaa005
- language
- English
- LU publication?
- yes
- id
- 30861c08-9ece-4a4b-a6b0-5baab5ab169f
- date added to LUP
- 2020-05-29 16:03:06
- date last changed
- 2023-12-18 22:31:03
@article{30861c08-9ece-4a4b-a6b0-5baab5ab169f, abstract = {{Background<br> Oat bran specifically increases colon butyrate concentrations and could therefore affect the progress of the disease in patients with ulcerative colitis (UC).<br> Methods<br> Patients with UC in remission were enrolled in a controlled multicenter study and randomized to eat oat bran or low-fiber wheat products.<br> Results<br> Ninety-four of the enrolled patients (n = 47 for both groups) completed the 24-week study. The oat bran group had significantly (P < 0.05) higher fecal butyrate concentrations and lower serum LDL levels, while deterioration of gastrointestinal symptoms was prevented, and subjective health maintained. The control diet significantly (P < 0.05) increased obstipation, reflux, and the symptom burden and had no effects on butyrate or LDL-cholesterol. The relapse rate was the same for both diets.<br> Conclusions<br> <br> Oat bran was well tolerated when given to patients with quiescent UC.}}, author = {{Nyman, Margareta and Nguyen, Thao Duy and Wikman, Ola and Hjortswang, Henrik and Hallert, C}}, issn = {{2631-827X}}, keywords = {{ulcerative colitis, β-glucan, oat bran, butyrate}}, language = {{eng}}, month = {{01}}, number = {{1}}, publisher = {{Oxford University Press}}, series = {{Crohns & Colitis 360}}, title = {{Oat Bran Increased Fecal Butyrate and Prevented Gastrointestinal Symptoms in Patients With Quiescent Ulcerative Colitis—Randomized Controlled Trial}}, url = {{http://dx.doi.org/10.1093/crocol/otaa005}}, doi = {{10.1093/crocol/otaa005}}, volume = {{2}}, year = {{2020}}, }