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Oat Bran Increased Fecal Butyrate and Prevented Gastrointestinal Symptoms in Patients With Quiescent Ulcerative Colitis—Randomized Controlled Trial

Nyman, Margareta LU ; Nguyen, Thao Duy LU orcid ; Wikman, Ola ; Hjortswang, Henrik and Hallert, C (2020) In Crohns & Colitis 360 2(1).
Abstract
Background
Oat bran specifically increases colon butyrate concentrations and could therefore affect the progress of the disease in patients with ulcerative colitis (UC).
Methods
Patients with UC in remission were enrolled in a controlled multicenter study and randomized to eat oat bran or low-fiber wheat products.
Results
Ninety-four of the enrolled patients (n = 47 for both groups) completed the 24-week study. The oat bran group had significantly (P < 0.05) higher fecal butyrate concentrations and lower serum LDL levels, while deterioration of gastrointestinal symptoms was prevented, and subjective health maintained. The control diet significantly (P < 0.05) increased obstipation, reflux, and the symptom burden... (More)
Background
Oat bran specifically increases colon butyrate concentrations and could therefore affect the progress of the disease in patients with ulcerative colitis (UC).
Methods
Patients with UC in remission were enrolled in a controlled multicenter study and randomized to eat oat bran or low-fiber wheat products.
Results
Ninety-four of the enrolled patients (n = 47 for both groups) completed the 24-week study. The oat bran group had significantly (P < 0.05) higher fecal butyrate concentrations and lower serum LDL levels, while deterioration of gastrointestinal symptoms was prevented, and subjective health maintained. The control diet significantly (P < 0.05) increased obstipation, reflux, and the symptom burden and had no effects on butyrate or LDL-cholesterol. The relapse rate was the same for both diets.
Conclusions

Oat bran was well tolerated when given to patients with quiescent UC. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ulcerative colitis, β-glucan, oat bran, butyrate
in
Crohns & Colitis 360
volume
2
issue
1
article number
2
pages
13 pages
publisher
Oxford University Press
external identifiers
  • scopus:85103804783
ISSN
2631-827X
DOI
10.1093/crocol/otaa005
language
English
LU publication?
yes
id
30861c08-9ece-4a4b-a6b0-5baab5ab169f
date added to LUP
2020-05-29 16:03:06
date last changed
2023-12-18 22:31:03
@article{30861c08-9ece-4a4b-a6b0-5baab5ab169f,
  abstract     = {{Background<br>
Oat bran specifically increases colon butyrate concentrations and could therefore affect the progress of the disease in patients with ulcerative colitis (UC).<br>
Methods<br>
Patients with UC in remission were enrolled in a controlled multicenter study and randomized to eat oat bran or low-fiber wheat products.<br>
Results<br>
Ninety-four of the enrolled patients (n = 47 for both groups) completed the 24-week study. The oat bran group had significantly (P &lt; 0.05) higher fecal butyrate concentrations and lower serum LDL levels, while deterioration of gastrointestinal symptoms was prevented, and subjective health maintained. The control diet significantly (P &lt; 0.05) increased obstipation, reflux, and the symptom burden and had no effects on butyrate or LDL-cholesterol. The relapse rate was the same for both diets.<br>
Conclusions<br>
<br>
Oat bran was well tolerated when given to patients with quiescent UC.}},
  author       = {{Nyman, Margareta and Nguyen, Thao Duy and Wikman, Ola and Hjortswang, Henrik and Hallert, C}},
  issn         = {{2631-827X}},
  keywords     = {{ulcerative colitis, β-glucan, oat bran, butyrate}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  publisher    = {{Oxford University Press}},
  series       = {{Crohns & Colitis 360}},
  title        = {{Oat Bran Increased Fecal Butyrate and Prevented Gastrointestinal Symptoms in Patients With Quiescent Ulcerative Colitis—Randomized Controlled Trial}},
  url          = {{http://dx.doi.org/10.1093/crocol/otaa005}},
  doi          = {{10.1093/crocol/otaa005}},
  volume       = {{2}},
  year         = {{2020}},
}