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Differential prognostic impact of the cyclins E and B in premenopausal and postmenopausal women with lymph node-negative breast cancer

Rudolph, P; Kuhling, H; Alm, Per LU ; Fernö, Mårten LU ; Baldetorp, Bo LU ; Olsson, Håkan LU and Parwaresch, R (2003) In International Journal of Cancer 105(5). p.674-680
Abstract
Searching for new prognostic factors, we investigated the influence of cyclin expression on breast cancer prognosis. A total of 273 archival tumor specimens from patients with pT1/pT2 NO breast cancers treated by surgery and local irradiation were immunostained for cyclins E, A and B. Outcome was evaluated as metastasis-free (MFS) and diseasespecific survival (DSS) over a median observation period of 99 months. In postmenopausal women, DSS was significantly predicted by cyclin E, and in premenopausal patients by cyclin B. No statistical significance was found for cyclin A. When the prognostic impact of cyclins was compared to that of standard prognostic indicators in a multivariate analysis, both cyclin E and cyclin B were selected as... (More)
Searching for new prognostic factors, we investigated the influence of cyclin expression on breast cancer prognosis. A total of 273 archival tumor specimens from patients with pT1/pT2 NO breast cancers treated by surgery and local irradiation were immunostained for cyclins E, A and B. Outcome was evaluated as metastasis-free (MFS) and diseasespecific survival (DSS) over a median observation period of 99 months. In postmenopausal women, DSS was significantly predicted by cyclin E, and in premenopausal patients by cyclin B. No statistical significance was found for cyclin A. When the prognostic impact of cyclins was compared to that of standard prognostic indicators in a multivariate analysis, both cyclin E and cyclin B were selected as independent predictors of survival in postmenopausal and premenopausal patients, respectively. After inclusion of Ki-67 in the model, cyclin E lost its significance, whereas cyclin B remained the only independent prognostic factor with a hazard ratio of 4.5 (p = 0.026) for tumor-related death. Assessment of cyclin expression may, therefore, refine current prognostic models if considered in relation to menopausal status. The prognostic relevance of cyclins is likely attributable to an influence on proliferation, cell survival and genetic instability. Awareness of the molecular mechanisms leading to deregulated cyclin expression may guide decisions for risk-adapted therapy regimens. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
menopause, prognosis, breast cancer, cell cycle, immunohistochemistry, cyclin E, cyclin B
in
International Journal of Cancer
volume
105
issue
5
pages
674 - 680
publisher
John Wiley & Sons
external identifiers
  • pmid:12740917
  • wos:000183474000015
  • scopus:0037837061
ISSN
0020-7136
DOI
10.1002/ijc.11132
language
English
LU publication?
yes
id
67c9e53f-27f4-4b68-85cb-9e7b8c322982 (old id 308901)
date added to LUP
2007-09-20 19:09:12
date last changed
2018-10-03 10:10:32
@article{67c9e53f-27f4-4b68-85cb-9e7b8c322982,
  abstract     = {Searching for new prognostic factors, we investigated the influence of cyclin expression on breast cancer prognosis. A total of 273 archival tumor specimens from patients with pT1/pT2 NO breast cancers treated by surgery and local irradiation were immunostained for cyclins E, A and B. Outcome was evaluated as metastasis-free (MFS) and diseasespecific survival (DSS) over a median observation period of 99 months. In postmenopausal women, DSS was significantly predicted by cyclin E, and in premenopausal patients by cyclin B. No statistical significance was found for cyclin A. When the prognostic impact of cyclins was compared to that of standard prognostic indicators in a multivariate analysis, both cyclin E and cyclin B were selected as independent predictors of survival in postmenopausal and premenopausal patients, respectively. After inclusion of Ki-67 in the model, cyclin E lost its significance, whereas cyclin B remained the only independent prognostic factor with a hazard ratio of 4.5 (p = 0.026) for tumor-related death. Assessment of cyclin expression may, therefore, refine current prognostic models if considered in relation to menopausal status. The prognostic relevance of cyclins is likely attributable to an influence on proliferation, cell survival and genetic instability. Awareness of the molecular mechanisms leading to deregulated cyclin expression may guide decisions for risk-adapted therapy regimens.},
  author       = {Rudolph, P and Kuhling, H and Alm, Per and Fernö, Mårten and Baldetorp, Bo and Olsson, Håkan and Parwaresch, R},
  issn         = {0020-7136},
  keyword      = {menopause,prognosis,breast cancer,cell cycle,immunohistochemistry,cyclin E,cyclin B},
  language     = {eng},
  number       = {5},
  pages        = {674--680},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Differential prognostic impact of the cyclins E and B in premenopausal and postmenopausal women with lymph node-negative breast cancer},
  url          = {http://dx.doi.org/10.1002/ijc.11132},
  volume       = {105},
  year         = {2003},
}