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Suppression of limbic motor seizures by electrical stimulation in thalamic reticular nucleus

Nanobashvili, Z; Chachua, T; Nanobashvili, Avtandil LU ; Bilanishvili, I; Lindvall, Olle LU and Kokaia, Zaal LU (2003) In Experimental Neurology 181(2). p.224-230
Abstract
Kindling is a model of temporal lobe epilepsy in which repeated electrical stimulations in limbic areas lead to progressive increase of seizure susceptibility, culminating in generalized convulsions and the establishment of a permanent epileptic syndrome. We studied here the effect of stimulations in the thalamic reticular nucleus (TRN) on. the development of seizures and hippocampal hyperexcitability in kindling elicited from the ventral hippocampus in rats. Animals given 12 kindling stimulations per day with 30-min intervals for 4 consecutive days developed generalized convulsions on day 4. Stimulations in TRN delivered simultaneously with those in the hippocampus induced marked suppression of seizure generalization. Similarly, the... (More)
Kindling is a model of temporal lobe epilepsy in which repeated electrical stimulations in limbic areas lead to progressive increase of seizure susceptibility, culminating in generalized convulsions and the establishment of a permanent epileptic syndrome. We studied here the effect of stimulations in the thalamic reticular nucleus (TRN) on. the development of seizures and hippocampal hyperexcitability in kindling elicited from the ventral hippocampus in rats. Animals given 12 kindling stimulations per day with 30-min intervals for 4 consecutive days developed generalized convulsions on day 4. Stimulations in TRN delivered simultaneously with those in the hippocampus induced marked suppression of seizure generalization. Similarly, the number of generalized seizures and the duration of behavioral convulsions were reduced when rats subjected to 40 kindling stimulations with 5-min intervals during about 3 h were costimulated in the TRN. The anticonvulsant effect of TRN costimulation was detected also when rats were test-stimulated in the hippocampus at 24 h and 2 and 4 weeks after the initial 40 hippocampal stimulations. Our data provide the first evidence that TRN stimulations can act to suppress limbic motor seizures in hippocampal kindling and suggest a new approach for seizure control in temporal lobe epilepsy. (C) 2003 Elsevier Science (USA). All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
generalization, seizure, hippocampus, kindling, thalamic reticular nucleus
in
Experimental Neurology
volume
181
issue
2
pages
224 - 230
publisher
Academic Press
external identifiers
  • pmid:12781995
  • wos:000183391000010
  • scopus:0038730930
ISSN
0014-4886
DOI
10.1016/S0014-4886(03)00045-1
language
English
LU publication?
yes
id
a1e02800-dd98-409b-b8a8-0affd9b429a5 (old id 308935)
date added to LUP
2007-09-18 14:33:56
date last changed
2018-01-07 05:27:07
@article{a1e02800-dd98-409b-b8a8-0affd9b429a5,
  abstract     = {Kindling is a model of temporal lobe epilepsy in which repeated electrical stimulations in limbic areas lead to progressive increase of seizure susceptibility, culminating in generalized convulsions and the establishment of a permanent epileptic syndrome. We studied here the effect of stimulations in the thalamic reticular nucleus (TRN) on. the development of seizures and hippocampal hyperexcitability in kindling elicited from the ventral hippocampus in rats. Animals given 12 kindling stimulations per day with 30-min intervals for 4 consecutive days developed generalized convulsions on day 4. Stimulations in TRN delivered simultaneously with those in the hippocampus induced marked suppression of seizure generalization. Similarly, the number of generalized seizures and the duration of behavioral convulsions were reduced when rats subjected to 40 kindling stimulations with 5-min intervals during about 3 h were costimulated in the TRN. The anticonvulsant effect of TRN costimulation was detected also when rats were test-stimulated in the hippocampus at 24 h and 2 and 4 weeks after the initial 40 hippocampal stimulations. Our data provide the first evidence that TRN stimulations can act to suppress limbic motor seizures in hippocampal kindling and suggest a new approach for seizure control in temporal lobe epilepsy. (C) 2003 Elsevier Science (USA). All rights reserved.},
  author       = {Nanobashvili, Z and Chachua, T and Nanobashvili, Avtandil and Bilanishvili, I and Lindvall, Olle and Kokaia, Zaal},
  issn         = {0014-4886},
  keyword      = {generalization,seizure,hippocampus,kindling,thalamic reticular nucleus},
  language     = {eng},
  number       = {2},
  pages        = {224--230},
  publisher    = {Academic Press},
  series       = {Experimental Neurology},
  title        = {Suppression of limbic motor seizures by electrical stimulation in thalamic reticular nucleus},
  url          = {http://dx.doi.org/10.1016/S0014-4886(03)00045-1},
  volume       = {181},
  year         = {2003},
}