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Long-Term Outcomes After Laparoscopy-Assisted Cryoablation for Renal Cell Carcinoma-Results From a Single-Center Series

Mesinovic, Denis LU ; Elfving, Peter LU ; Karadzic, Violeta LU ; Scholtz, Bianca LU ; Sundqvist, Pernilla and Liedberg, Fredrik LU (2026) In Archivos Espanoles de Urologia 79(4). p.591-597
Abstract

Introduction: Laparoscopic-assisted renal cryoablation (LRC) is a treatment option for small renal masses (SRMs), offering a nephron-sparing alternative to partial nephrectomy. This study evaluated long-term oncologic outcomes and perioperative complications after LRC in a single-center cohort. Methods: We conducted a retrospective single-center review of 52 patients who underwent LRC for SRMs ≤4 cm between 2006 and 2015. Primary outcomes included local recurrence-free survival (LRFS), metastasis-free survival (MFS), and overall survival (OS). Secondary outcomes included 90-day postoperative complications graded by the Clavien-Dindo system. Results: The 5-and 10-year LRFS were 90% (95% Confidence Interval (CI) 86-94%) and 90% (95% CI... (More)

Introduction: Laparoscopic-assisted renal cryoablation (LRC) is a treatment option for small renal masses (SRMs), offering a nephron-sparing alternative to partial nephrectomy. This study evaluated long-term oncologic outcomes and perioperative complications after LRC in a single-center cohort. Methods: We conducted a retrospective single-center review of 52 patients who underwent LRC for SRMs ≤4 cm between 2006 and 2015. Primary outcomes included local recurrence-free survival (LRFS), metastasis-free survival (MFS), and overall survival (OS). Secondary outcomes included 90-day postoperative complications graded by the Clavien-Dindo system. Results: The 5-and 10-year LRFS were 90% (95% Confidence Interval (CI) 86-94%) and 90% (95% CI 86–94%), and MFS were 94% (95% CI 92–97%) and 94% (95% CI 92–97%), respectively. OS for patients with malignant histology was 87% (CI 82– 91%). Approximately 30% of patients had benign tumors. The overall complication rate was 21%. No perioperative mortality occurred. Conclusions: LRC provided effective long-term local tumor control with acceptable complication rates in patients with SRMs. However, the lack of preprocedural biopsy led to overtreatment of benign tumors. The findings highlight the importance of histologic confirmation prior to ablation.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
long-term oncologic outcomes, renal cell carcinoma, renal cryoablation, small renal mass
in
Archivos Espanoles de Urologia
volume
79
issue
4
pages
7 pages
publisher
Iniestares, S.A.
external identifiers
  • pmid:42265957
  • scopus:105040153982
ISSN
0004-0614
DOI
10.56434/j.arch.esp.urol.20267904.69
language
English
LU publication?
yes
id
30f9d3b6-2489-4ed8-8597-03756d0ee2d4
date added to LUP
2026-08-21 15:17:08
date last changed
2026-09-04 16:16:59
@article{30f9d3b6-2489-4ed8-8597-03756d0ee2d4,
  abstract     = {{<p>Introduction: Laparoscopic-assisted renal cryoablation (LRC) is a treatment option for small renal masses (SRMs), offering a nephron-sparing alternative to partial nephrectomy. This study evaluated long-term oncologic outcomes and perioperative complications after LRC in a single-center cohort. Methods: We conducted a retrospective single-center review of 52 patients who underwent LRC for SRMs ≤4 cm between 2006 and 2015. Primary outcomes included local recurrence-free survival (LRFS), metastasis-free survival (MFS), and overall survival (OS). Secondary outcomes included 90-day postoperative complications graded by the Clavien-Dindo system. Results: The 5-and 10-year LRFS were 90% (95% Confidence Interval (CI) 86-94%) and 90% (95% CI 86–94%), and MFS were 94% (95% CI 92–97%) and 94% (95% CI 92–97%), respectively. OS for patients with malignant histology was 87% (CI 82– 91%). Approximately 30% of patients had benign tumors. The overall complication rate was 21%. No perioperative mortality occurred. Conclusions: LRC provided effective long-term local tumor control with acceptable complication rates in patients with SRMs. However, the lack of preprocedural biopsy led to overtreatment of benign tumors. The findings highlight the importance of histologic confirmation prior to ablation.</p>}},
  author       = {{Mesinovic, Denis and Elfving, Peter and Karadzic, Violeta and Scholtz, Bianca and Sundqvist, Pernilla and Liedberg, Fredrik}},
  issn         = {{0004-0614}},
  keywords     = {{long-term oncologic outcomes; renal cell carcinoma; renal cryoablation; small renal mass}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{4}},
  pages        = {{591--597}},
  publisher    = {{Iniestares, S.A.}},
  series       = {{Archivos Espanoles de Urologia}},
  title        = {{Long-Term Outcomes After Laparoscopy-Assisted Cryoablation for Renal Cell Carcinoma-Results From a Single-Center Series}},
  url          = {{http://dx.doi.org/10.56434/j.arch.esp.urol.20267904.69}},
  doi          = {{10.56434/j.arch.esp.urol.20267904.69}},
  volume       = {{79}},
  year         = {{2026}},
}