Associations of Macronutrients Intake With MRI-determined Hepatic Fat Content, Hepatic Fibroinflammation, and NAFLD
Chen, Shen ; Pang, Juan ; Huang, Rong ; You, Yiran ; Zhang, Haoyang LU
; Xue, Hongliang
and Chen, Xu
(2023)
In The Journal of clinical endocrinology and metabolism
108(12).
p.1660-1669
- Abstract
CONTEXT: A healthy lifestyle is the cornerstone of management in nonalcoholic fatty liver disease (NAFLD). However, the associations between dietary macronutrient composition and different aspects of NAFLD pathology are unclear and dietary recommendations for NAFLD are lacking.
OBJECTIVE: This work aimed to evaluate the associations of dietary macronutrient composition with hepatic steatosis, hepatic fibroinflammation, and NAFLD.
METHODS: In this cross-sectional study, a total of 12 620 UK Biobank participants who completed both the dietary questionnaire and magnetic resonance imaging (MRI) examination were included in this study. Dietary consumption of macronutrient was self-reported and calculated. MRI-determined hepatic... (More)
CONTEXT: A healthy lifestyle is the cornerstone of management in nonalcoholic fatty liver disease (NAFLD). However, the associations between dietary macronutrient composition and different aspects of NAFLD pathology are unclear and dietary recommendations for NAFLD are lacking.
OBJECTIVE: This work aimed to evaluate the associations of dietary macronutrient composition with hepatic steatosis, hepatic fibroinflammation, and NAFLD.
METHODS: In this cross-sectional study, a total of 12 620 UK Biobank participants who completed both the dietary questionnaire and magnetic resonance imaging (MRI) examination were included in this study. Dietary consumption of macronutrient was self-reported and calculated. MRI-determined hepatic fat content, fibroinflammation, and NAFLD were estimated.
RESULTS: First, we found that saturated fatty acid (SFA) intake was associated with higher hepatic steatosis, fibroinflammation, and NAFLD prevalence. In contrast, higher fiber or protein intake was reversely correlated with hepatic steatosis and fibroinflammation. Interestingly, starch or sugar intake was significantly associated with hepatic fibroinflammation, whereas monounsaturated fatty acid (MUFA) intake was negatively correlated with hepatic fibroinflammation. Isocaloric analysis revealed that replacing SFA with sugar, fiber, or protein was significantly associated with a reduction in hepatic steatosis, while replacing starch, sugar, or SFA with protein or MUFA was significantly correlated with a decrease in hepatic fibroinflammation.
CONCLUSION: Overall, our results demonstrate that specific macronutrients are associated with different aspects of NAFLD, and specific dietary compositions should be recommended for distinct NAFLD-risk populations.
(Less)
- author
- Chen, Shen
; Pang, Juan
; Huang, Rong
; You, Yiran
; Zhang, Haoyang
LU
; Xue, Hongliang
and Chen, Xu
- publishing date
- 2023-11-17
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Humans, Non-alcoholic Fatty Liver Disease/diagnostic imaging, Cross-Sectional Studies, Liver/diagnostic imaging, Fatty Acids, Monounsaturated, Nutrients, Starch, Magnetic Resonance Imaging, Sugars
- in
- The Journal of clinical endocrinology and metabolism
- volume
- 108
- issue
- 12
- pages
- 1660 - 1669
- publisher
- Oxford University Press
- external identifiers
-
- scopus:85176122355
- pmid:37290038
- ISSN
- 1945-7197
- DOI
- 10.1210/clinem/dgad346
- language
- English
- LU publication?
- no
- additional info
- © The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
- id
- 31159db0-c1cb-4724-bd70-c5b1458f00c8
- date added to LUP
- 2024-02-05 15:06:23
- date last changed
- 2024-04-22 10:56:17
@article{31159db0-c1cb-4724-bd70-c5b1458f00c8,
abstract = {{<p>CONTEXT: A healthy lifestyle is the cornerstone of management in nonalcoholic fatty liver disease (NAFLD). However, the associations between dietary macronutrient composition and different aspects of NAFLD pathology are unclear and dietary recommendations for NAFLD are lacking.</p><p>OBJECTIVE: This work aimed to evaluate the associations of dietary macronutrient composition with hepatic steatosis, hepatic fibroinflammation, and NAFLD.</p><p>METHODS: In this cross-sectional study, a total of 12 620 UK Biobank participants who completed both the dietary questionnaire and magnetic resonance imaging (MRI) examination were included in this study. Dietary consumption of macronutrient was self-reported and calculated. MRI-determined hepatic fat content, fibroinflammation, and NAFLD were estimated.</p><p>RESULTS: First, we found that saturated fatty acid (SFA) intake was associated with higher hepatic steatosis, fibroinflammation, and NAFLD prevalence. In contrast, higher fiber or protein intake was reversely correlated with hepatic steatosis and fibroinflammation. Interestingly, starch or sugar intake was significantly associated with hepatic fibroinflammation, whereas monounsaturated fatty acid (MUFA) intake was negatively correlated with hepatic fibroinflammation. Isocaloric analysis revealed that replacing SFA with sugar, fiber, or protein was significantly associated with a reduction in hepatic steatosis, while replacing starch, sugar, or SFA with protein or MUFA was significantly correlated with a decrease in hepatic fibroinflammation.</p><p>CONCLUSION: Overall, our results demonstrate that specific macronutrients are associated with different aspects of NAFLD, and specific dietary compositions should be recommended for distinct NAFLD-risk populations.</p>}},
author = {{Chen, Shen and Pang, Juan and Huang, Rong and You, Yiran and Zhang, Haoyang and Xue, Hongliang and Chen, Xu}},
issn = {{1945-7197}},
keywords = {{Humans; Non-alcoholic Fatty Liver Disease/diagnostic imaging; Cross-Sectional Studies; Liver/diagnostic imaging; Fatty Acids, Monounsaturated; Nutrients; Starch; Magnetic Resonance Imaging; Sugars}},
language = {{eng}},
month = {{11}},
number = {{12}},
pages = {{1660--1669}},
publisher = {{Oxford University Press}},
series = {{The Journal of clinical endocrinology and metabolism}},
title = {{Associations of Macronutrients Intake With MRI-determined Hepatic Fat Content, Hepatic Fibroinflammation, and NAFLD}},
url = {{http://dx.doi.org/10.1210/clinem/dgad346}},
doi = {{10.1210/clinem/dgad346}},
volume = {{108}},
year = {{2023}},
}