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Endothelial damage after treatment with low-molecular weight heparins - a morphological study

Kinhult, Sara LU ; Eskilsson, Jan LU ; Albertsson, Maria LU and Cwikiel, Magdalena LU (2003) In Scandinavian Cardiovascular Journal1997-01-01+01:00 37(1). p.30-33
Abstract
Objective-Recent studies failed to show long-term benefit with low-molecular weight heparins (LMWH) in unstable coronary heart disease. A previous study of vascular effects of the cytostatic agent 5-fluorouracil (5-FU) showed that dalteparin prevented thrombosis induced by 5-FU but endothelial damage was not ameliorated and was present also in animals treated with dalteparin only. This study investigates the influence of LMWH currently in clinical use on arterial endothelium in vivo. Design-Eighty rabbits in four groups were treated with dalteparin, enoxaparin, tinzaparin and saline, respectively. Arterial endothelium was examined after 3, 14, 30 and 60 days with scanning electron microscopy. Results-All three groups treated with LMWH... (More)
Objective-Recent studies failed to show long-term benefit with low-molecular weight heparins (LMWH) in unstable coronary heart disease. A previous study of vascular effects of the cytostatic agent 5-fluorouracil (5-FU) showed that dalteparin prevented thrombosis induced by 5-FU but endothelial damage was not ameliorated and was present also in animals treated with dalteparin only. This study investigates the influence of LMWH currently in clinical use on arterial endothelium in vivo. Design-Eighty rabbits in four groups were treated with dalteparin, enoxaparin, tinzaparin and saline, respectively. Arterial endothelium was examined after 3, 14, 30 and 60 days with scanning electron microscopy. Results-All three groups treated with LMWH showed moderate damage to the endothelium, with contracted vessel wall and endothelial cells, cell membrane damage, denudation of subendothelium and adhering platelets. Contrarily, the control group exhibited a normal endothelium. Conclusion-Morphologic examination of arterial endothelium shows that all investigated LMWH exert a moderate toxic effect on endothelial cells. The clinical impact of these observations, e. g. concerning effect of long-term LMWH treatment, needs to be further elucidated. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
scanning electron microscopy, endothelium, low molecular weight heparin
in
Scandinavian Cardiovascular Journal1997-01-01+01:00
volume
37
issue
1
pages
30 - 33
publisher
Taylor & Francis
external identifiers
  • wos:000182593000005
  • pmid:12745800
  • scopus:0037649979
ISSN
1651-2006
DOI
language
English
LU publication?
yes
id
133e8466-c0e8-40c8-ba09-41a1814ba0b3 (old id 312395)
date added to LUP
2007-09-16 07:40:30
date last changed
2018-05-29 10:09:36
@article{133e8466-c0e8-40c8-ba09-41a1814ba0b3,
  abstract     = {Objective-Recent studies failed to show long-term benefit with low-molecular weight heparins (LMWH) in unstable coronary heart disease. A previous study of vascular effects of the cytostatic agent 5-fluorouracil (5-FU) showed that dalteparin prevented thrombosis induced by 5-FU but endothelial damage was not ameliorated and was present also in animals treated with dalteparin only. This study investigates the influence of LMWH currently in clinical use on arterial endothelium in vivo. Design-Eighty rabbits in four groups were treated with dalteparin, enoxaparin, tinzaparin and saline, respectively. Arterial endothelium was examined after 3, 14, 30 and 60 days with scanning electron microscopy. Results-All three groups treated with LMWH showed moderate damage to the endothelium, with contracted vessel wall and endothelial cells, cell membrane damage, denudation of subendothelium and adhering platelets. Contrarily, the control group exhibited a normal endothelium. Conclusion-Morphologic examination of arterial endothelium shows that all investigated LMWH exert a moderate toxic effect on endothelial cells. The clinical impact of these observations, e. g. concerning effect of long-term LMWH treatment, needs to be further elucidated.},
  author       = {Kinhult, Sara and Eskilsson, Jan and Albertsson, Maria and Cwikiel, Magdalena},
  issn         = {1651-2006},
  keyword      = {scanning electron microscopy,endothelium,low molecular weight heparin},
  language     = {eng},
  number       = {1},
  pages        = {30--33},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Cardiovascular Journal1997-01-01+01:00},
  title        = {Endothelial damage after treatment with low-molecular weight heparins - a morphological study},
  url          = {http://dx.doi.org/},
  volume       = {37},
  year         = {2003},
}