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Gender differences in outcome after stent treatment of lesions in the femoropopliteal segment.

Lindgren, Hans LU ; Gottsäter, Anders LU ; Hermansson, Karin LU ; Qvarfordt, Peter LU and Bergman, Stefan LU (2012) In Scandinavian Journal of Surgery 101(3). p.177-183
Abstract
Background and Aims:

Although endovascular stent treatment is increasingly used in infrain-guinal atherosclerotic occlusive disease, outcome with focus on gender differences has not been reported in detail.



Material and Methods:

One hundred and twelve consecutive patients (67 [60%]) women, un-dergoing endovascular nitinol stent treatment of atherosclerotic lesions in the femoropopliteal segment were analysed concerning improvement in ankle brachial index (ABI), reinterventions, complications, amputation and survival rates up to 12 months after intervention. Risk factors for amputation and death were analyzed with logistic regression.



Results: At presentation, women showed critical... (More)
Background and Aims:

Although endovascular stent treatment is increasingly used in infrain-guinal atherosclerotic occlusive disease, outcome with focus on gender differences has not been reported in detail.



Material and Methods:

One hundred and twelve consecutive patients (67 [60%]) women, un-dergoing endovascular nitinol stent treatment of atherosclerotic lesions in the femoropopliteal segment were analysed concerning improvement in ankle brachial index (ABI), reinterventions, complications, amputation and survival rates up to 12 months after intervention. Risk factors for amputation and death were analyzed with logistic regression.



Results: At presentation, women showed critical limb ischemia (CLI) more often than men (87% vs. 58 %; P = 0.001). After 12 months ABI had improved (from 0.40 ± 0.26 at baseline to 0.86 ± 0.22 after 12 months, P < 0.001), but 16 patients (15%) had been amputated and 27 patients (24 %) had died. After adjustment for age, diabetes mellitus and smoking, female gender was an independent risk factor for amputation (OR 9.0; 95% CI 1.1-76.5; P = 0.045).



Conclusions: Stent treatment of lesions in the femoropopliteal segment had favourable effects on ABI and limb salvage. Treated women more often had CLI and ran a higher risk for amputation within 12 months than men. This might reflect failure of clinicians to adequately appreciate symptoms of atherosclerotic leg artery disease in women. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Surgery
volume
101
issue
3
pages
177 - 183
publisher
Finnish Surgical Society
external identifiers
  • wos:000309332500007
  • pmid:22968241
  • scopus:84867054594
ISSN
1799-7267
language
English
LU publication?
yes
id
0a4ca870-e3b7-4cb3-93be-2d6f362cf0ae (old id 3124032)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22968241?dopt=Abstract
date added to LUP
2012-10-03 21:22:43
date last changed
2017-03-12 04:20:09
@article{0a4ca870-e3b7-4cb3-93be-2d6f362cf0ae,
  abstract     = {Background and Aims: <br/><br>
Although endovascular stent treatment is increasingly used in infrain-guinal atherosclerotic occlusive disease, outcome with focus on gender differences has not been reported in detail.<br/><br>
<br/><br>
Material and Methods: <br/><br>
One hundred and twelve consecutive patients (67 [60%]) women, un-dergoing endovascular nitinol stent treatment of atherosclerotic lesions in the femoropopliteal segment were analysed concerning improvement in ankle brachial index (ABI), reinterventions, complications, amputation and survival rates up to 12 months after intervention. Risk factors for amputation and death were analyzed with logistic regression.<br/><br>
<br/><br>
Results: At presentation, women showed critical limb ischemia (CLI) more often than men (87% vs. 58 %; P = 0.001). After 12 months ABI had improved (from 0.40 ± 0.26 at baseline to 0.86 ± 0.22 after 12 months, P &lt; 0.001), but 16 patients (15%) had been amputated and 27 patients (24 %) had died. After adjustment for age, diabetes mellitus and smoking, female gender was an independent risk factor for amputation (OR 9.0; 95% CI 1.1-76.5; P = 0.045).<br/><br>
<br/><br>
Conclusions: Stent treatment of lesions in the femoropopliteal segment had favourable effects on ABI and limb salvage. Treated women more often had CLI and ran a higher risk for amputation within 12 months than men. This might reflect failure of clinicians to adequately appreciate symptoms of atherosclerotic leg artery disease in women.},
  author       = {Lindgren, Hans and Gottsäter, Anders and Hermansson, Karin and Qvarfordt, Peter and Bergman, Stefan},
  issn         = {1799-7267},
  language     = {eng},
  number       = {3},
  pages        = {177--183},
  publisher    = {Finnish Surgical Society},
  series       = {Scandinavian Journal of Surgery},
  title        = {Gender differences in outcome after stent treatment of lesions in the femoropopliteal segment.},
  volume       = {101},
  year         = {2012},
}