Gender differences in outcome after stent treatment of lesions in the femoropopliteal segment.
(2012) In Scandinavian Journal of Surgery 101(3). p.177-183- Abstract
- Background and Aims:
Although endovascular stent treatment is increasingly used in infrain-guinal atherosclerotic occlusive disease, outcome with focus on gender differences has not been reported in detail.
Material and Methods:
One hundred and twelve consecutive patients (67 [60%]) women, un-dergoing endovascular nitinol stent treatment of atherosclerotic lesions in the femoropopliteal segment were analysed concerning improvement in ankle brachial index (ABI), reinterventions, complications, amputation and survival rates up to 12 months after intervention. Risk factors for amputation and death were analyzed with logistic regression.
Results: At presentation, women showed critical... (More) - Background and Aims:
Although endovascular stent treatment is increasingly used in infrain-guinal atherosclerotic occlusive disease, outcome with focus on gender differences has not been reported in detail.
Material and Methods:
One hundred and twelve consecutive patients (67 [60%]) women, un-dergoing endovascular nitinol stent treatment of atherosclerotic lesions in the femoropopliteal segment were analysed concerning improvement in ankle brachial index (ABI), reinterventions, complications, amputation and survival rates up to 12 months after intervention. Risk factors for amputation and death were analyzed with logistic regression.
Results: At presentation, women showed critical limb ischemia (CLI) more often than men (87% vs. 58 %; P = 0.001). After 12 months ABI had improved (from 0.40 ± 0.26 at baseline to 0.86 ± 0.22 after 12 months, P < 0.001), but 16 patients (15%) had been amputated and 27 patients (24 %) had died. After adjustment for age, diabetes mellitus and smoking, female gender was an independent risk factor for amputation (OR 9.0; 95% CI 1.1-76.5; P = 0.045).
Conclusions: Stent treatment of lesions in the femoropopliteal segment had favourable effects on ABI and limb salvage. Treated women more often had CLI and ran a higher risk for amputation within 12 months than men. This might reflect failure of clinicians to adequately appreciate symptoms of atherosclerotic leg artery disease in women. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3124032
- author
- Lindgren, Hans LU ; Gottsäter, Anders LU ; Hermansson, Karin LU ; Qvarfordt, Peter LU and Bergman, Stefan LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Surgery
- volume
- 101
- issue
- 3
- pages
- 177 - 183
- publisher
- Finnish Surgical Society
- external identifiers
-
- wos:000309332500007
- pmid:22968241
- scopus:84867054594
- ISSN
- 1799-7267
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Rheumatology (013036000), Division of Nursing (Closed 2012) (013065000), Unit for Clinical Vascular Disease Research (013242410)
- id
- 0a4ca870-e3b7-4cb3-93be-2d6f362cf0ae (old id 3124032)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22968241?dopt=Abstract
- date added to LUP
- 2016-04-04 08:55:56
- date last changed
- 2022-04-23 18:31:36
@article{0a4ca870-e3b7-4cb3-93be-2d6f362cf0ae, abstract = {{Background and Aims: <br/><br> Although endovascular stent treatment is increasingly used in infrain-guinal atherosclerotic occlusive disease, outcome with focus on gender differences has not been reported in detail.<br/><br> <br/><br> Material and Methods: <br/><br> One hundred and twelve consecutive patients (67 [60%]) women, un-dergoing endovascular nitinol stent treatment of atherosclerotic lesions in the femoropopliteal segment were analysed concerning improvement in ankle brachial index (ABI), reinterventions, complications, amputation and survival rates up to 12 months after intervention. Risk factors for amputation and death were analyzed with logistic regression.<br/><br> <br/><br> Results: At presentation, women showed critical limb ischemia (CLI) more often than men (87% vs. 58 %; P = 0.001). After 12 months ABI had improved (from 0.40 ± 0.26 at baseline to 0.86 ± 0.22 after 12 months, P < 0.001), but 16 patients (15%) had been amputated and 27 patients (24 %) had died. After adjustment for age, diabetes mellitus and smoking, female gender was an independent risk factor for amputation (OR 9.0; 95% CI 1.1-76.5; P = 0.045).<br/><br> <br/><br> Conclusions: Stent treatment of lesions in the femoropopliteal segment had favourable effects on ABI and limb salvage. Treated women more often had CLI and ran a higher risk for amputation within 12 months than men. This might reflect failure of clinicians to adequately appreciate symptoms of atherosclerotic leg artery disease in women.}}, author = {{Lindgren, Hans and Gottsäter, Anders and Hermansson, Karin and Qvarfordt, Peter and Bergman, Stefan}}, issn = {{1799-7267}}, language = {{eng}}, number = {{3}}, pages = {{177--183}}, publisher = {{Finnish Surgical Society}}, series = {{Scandinavian Journal of Surgery}}, title = {{Gender differences in outcome after stent treatment of lesions in the femoropopliteal segment.}}, url = {{http://www.ncbi.nlm.nih.gov/pubmed/22968241?dopt=Abstract}}, volume = {{101}}, year = {{2012}}, }