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Experimental determination of the respiratory tract deposition of diesel combustion particles in patients with chronic obstructive pulmonary disease

Löndahl, Jakob LU ; Swietlicki, Erik LU ; Rissler, Jenny LU ; Bengtsson, Agneta LU ; Boman, Christoffer; Blomberg, Anders and Sandstrom, Thomas (2012) In Particle and Fibre Toxicology 9.
Abstract
Background: Air pollution, mainly from combustion, is one of the leading global health risk factors. A susceptible group is the more than 200 million people worldwide suffering from chronic obstructive pulmonary disease (COPD). There are few data on lung deposition of airborne particles in patients with COPD and none for combustion particles. Objectives: To determine respiratory tract deposition of diesel combustion particles in patients with COPD during spontaneous breathing. Methods: Ten COPD patients and seven healthy subjects inhaled diesel exhaust particles generated during idling and transient driving in an exposure chamber. The respiratory tract deposition of the particles was measured in the size range 10-500 nm during spontaneous... (More)
Background: Air pollution, mainly from combustion, is one of the leading global health risk factors. A susceptible group is the more than 200 million people worldwide suffering from chronic obstructive pulmonary disease (COPD). There are few data on lung deposition of airborne particles in patients with COPD and none for combustion particles. Objectives: To determine respiratory tract deposition of diesel combustion particles in patients with COPD during spontaneous breathing. Methods: Ten COPD patients and seven healthy subjects inhaled diesel exhaust particles generated during idling and transient driving in an exposure chamber. The respiratory tract deposition of the particles was measured in the size range 10-500 nm during spontaneous breathing. Results: The deposited dose rate increased with increasing severity of the disease. However, the deposition probability of the ultrafine combustion particles (< 100 nm) was decreased in COPD patients. The deposition probability was associated with both breathing parameters and lung function, but could be predicted only based on lung function. Conclusions: The higher deposited dose rate of inhaled air pollution particles in COPD patients may be one of the factors contributing to their increased vulnerability. The strong correlations between lung function and particle deposition, especially in the size range of 20-30 nm, suggest that altered particle deposition could be used as an indicator respiratory disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Lung deposition, Toxicity, Health effects, Air pollution, Agglomerate, Nanoparticles, Aerosol, COPD, Diesel exhaust
in
Particle and Fibre Toxicology
volume
9
publisher
BioMed Central
external identifiers
  • wos:000308668200001
  • scopus:84864229214
ISSN
1743-8977
DOI
10.1186/1743-8977-9-30
language
English
LU publication?
yes
id
7f4c4ecc-a946-4801-b560-9c8dd0a21567 (old id 3139769)
date added to LUP
2012-11-01 11:08:33
date last changed
2017-06-25 03:50:06
@article{7f4c4ecc-a946-4801-b560-9c8dd0a21567,
  abstract     = {Background: Air pollution, mainly from combustion, is one of the leading global health risk factors. A susceptible group is the more than 200 million people worldwide suffering from chronic obstructive pulmonary disease (COPD). There are few data on lung deposition of airborne particles in patients with COPD and none for combustion particles. Objectives: To determine respiratory tract deposition of diesel combustion particles in patients with COPD during spontaneous breathing. Methods: Ten COPD patients and seven healthy subjects inhaled diesel exhaust particles generated during idling and transient driving in an exposure chamber. The respiratory tract deposition of the particles was measured in the size range 10-500 nm during spontaneous breathing. Results: The deposited dose rate increased with increasing severity of the disease. However, the deposition probability of the ultrafine combustion particles (&lt; 100 nm) was decreased in COPD patients. The deposition probability was associated with both breathing parameters and lung function, but could be predicted only based on lung function. Conclusions: The higher deposited dose rate of inhaled air pollution particles in COPD patients may be one of the factors contributing to their increased vulnerability. The strong correlations between lung function and particle deposition, especially in the size range of 20-30 nm, suggest that altered particle deposition could be used as an indicator respiratory disease.},
  author       = {Löndahl, Jakob and Swietlicki, Erik and Rissler, Jenny and Bengtsson, Agneta and Boman, Christoffer and Blomberg, Anders and Sandstrom, Thomas},
  issn         = {1743-8977},
  keyword      = {Lung deposition,Toxicity,Health effects,Air pollution,Agglomerate,Nanoparticles,Aerosol,COPD,Diesel exhaust},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {Particle and Fibre Toxicology},
  title        = {Experimental determination of the respiratory tract deposition of diesel combustion particles in patients with chronic obstructive pulmonary disease},
  url          = {http://dx.doi.org/10.1186/1743-8977-9-30},
  volume       = {9},
  year         = {2012},
}