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ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value

Vandesompele, J ; Edsjö, Anders LU ; De Preter, K ; Axelson, Håkan LU ; Speleman, F and Påhlman, Sven LU (2003) In Oncogene 22(3). p.456-460
Abstract
The MYCN proto-oncogene is frequently amplified in a subgroup of highly aggressive neuroblastomas. The molecular mechanism(s) by which the overexpressed MYCN contributes to an aggressive tumor cell behavior is not well understood. Recently, it was reported that the ID2 gene is a direct target for the MYCN and MYC transcription factors, and that ID2 expression and MYCN amplification correlate positively in neuroblastoma. In addition, ID2 expression was proposed as a negative prognostic parameter. As these results are of potential clinical importance, but not in agreement with our own initial observations, the putative correlation between ID2 and MYC(N) expression in neuroblastoma cell lines and tumors was reinvestigated. We found no... (More)
The MYCN proto-oncogene is frequently amplified in a subgroup of highly aggressive neuroblastomas. The molecular mechanism(s) by which the overexpressed MYCN contributes to an aggressive tumor cell behavior is not well understood. Recently, it was reported that the ID2 gene is a direct target for the MYCN and MYC transcription factors, and that ID2 expression and MYCN amplification correlate positively in neuroblastoma. In addition, ID2 expression was proposed as a negative prognostic parameter. As these results are of potential clinical importance, but not in agreement with our own initial observations, the putative correlation between ID2 and MYC(N) expression in neuroblastoma cell lines and tumors was reinvestigated. We found no correlation between MYCN and ID2 expression in neuroblastoma cell lines or tumor specimens. However, we did find a significant positive correlation between MYC and ID2 expressions in both MYCN-amplified and single-copy tumor specimens, and in MYCN single-copy cell lines. As previously reported, we also found an inverse correlation between MYC and MYCN expressions. Importantly, we could not confirm the reported prognostic power of ID2-expression in neuroblastoma. These data, obtained in two independent laboratories, challenge the previously proposed ID2-MYCN relation. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
prognosis, neuroblastoma, MYCN, ID2, MYC
in
Oncogene
volume
22
issue
3
pages
456 - 460
publisher
Nature Publishing Group
external identifiers
  • pmid:12545167
  • wos:000180379100015
  • scopus:0037461898
  • pmid:12545167
ISSN
1476-5594
DOI
10.1038/sj.onc.1206148
language
English
LU publication?
yes
id
313cc942-50b4-4aec-aa68-18e5c616612b (old id 319725)
date added to LUP
2016-04-01 12:33:09
date last changed
2022-01-27 06:38:35
@article{313cc942-50b4-4aec-aa68-18e5c616612b,
  abstract     = {{The MYCN proto-oncogene is frequently amplified in a subgroup of highly aggressive neuroblastomas. The molecular mechanism(s) by which the overexpressed MYCN contributes to an aggressive tumor cell behavior is not well understood. Recently, it was reported that the ID2 gene is a direct target for the MYCN and MYC transcription factors, and that ID2 expression and MYCN amplification correlate positively in neuroblastoma. In addition, ID2 expression was proposed as a negative prognostic parameter. As these results are of potential clinical importance, but not in agreement with our own initial observations, the putative correlation between ID2 and MYC(N) expression in neuroblastoma cell lines and tumors was reinvestigated. We found no correlation between MYCN and ID2 expression in neuroblastoma cell lines or tumor specimens. However, we did find a significant positive correlation between MYC and ID2 expressions in both MYCN-amplified and single-copy tumor specimens, and in MYCN single-copy cell lines. As previously reported, we also found an inverse correlation between MYC and MYCN expressions. Importantly, we could not confirm the reported prognostic power of ID2-expression in neuroblastoma. These data, obtained in two independent laboratories, challenge the previously proposed ID2-MYCN relation.}},
  author       = {{Vandesompele, J and Edsjö, Anders and De Preter, K and Axelson, Håkan and Speleman, F and Påhlman, Sven}},
  issn         = {{1476-5594}},
  keywords     = {{prognosis; neuroblastoma; MYCN; ID2; MYC}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{456--460}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Oncogene}},
  title        = {{ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value}},
  url          = {{http://dx.doi.org/10.1038/sj.onc.1206148}},
  doi          = {{10.1038/sj.onc.1206148}},
  volume       = {{22}},
  year         = {{2003}},
}