Advanced

Boron neutron capture therapy for glioblastoma multiforme: clinical studies in Sweden

Capala, J; Stenstam, BH; Skold, KS; Munck af Rosenschöld, Per LU ; Giusti, V; Persson, C; Wallin, E; Brun, A; Franzen, L and Carlsson, JO, et al. (2003) In Journal of Neurooncology 62(1). p.135-144
Abstract
A boron neutron capture therapy ( BNCT) facility has been constructed at Studsvik, Sweden. It includes two filter/ moderator configurations. One of the resulting neutron beams has been optimized for clinical irradiations with a filter/ moderator system that allows easy variation of the neutron spectrum from the thermal to the epithermal energy range. The other beam has been designed to produce a large uniform field of thermal neutrons for radiobiological research. Scientific operations of the Studsvik BNCT project are overseen by the Scientific Advisory Board comprised of representatives of major universities in Sweden. Furthermore, special task groups for clinical and preclinical studies have been formed to facilitate collaboration with... (More)
A boron neutron capture therapy ( BNCT) facility has been constructed at Studsvik, Sweden. It includes two filter/ moderator configurations. One of the resulting neutron beams has been optimized for clinical irradiations with a filter/ moderator system that allows easy variation of the neutron spectrum from the thermal to the epithermal energy range. The other beam has been designed to produce a large uniform field of thermal neutrons for radiobiological research. Scientific operations of the Studsvik BNCT project are overseen by the Scientific Advisory Board comprised of representatives of major universities in Sweden. Furthermore, special task groups for clinical and preclinical studies have been formed to facilitate collaboration with academia. The clinical Phase II trials for glioblastoma are sponsored by the Swedish National Neuro- Oncology Group and, presently, involve a protocol for BNCT treatment of glioblastoma patients who have not received any therapy other than surgery. In this protocol, p- boronophenylalanine ( BPA), administered as a 6- h intravenous infusion, is used as the boron delivery agent. As of January 2002, 17 patients were treated. The 6- h infusion of 900 mg BPA/ kg body weight was shown to be safe and resulted in the average blood - boron concentration of 24 mu g/ g ( range: 15 - 32 mu g/ g) at the time of irradiation ( approximately 2 - 3 h post- infusion). Peak and average weighted radiation doses to the brain were in the ranges of 8.0 - 15.5 Gy( W) and 3.3 - 6.1 Gy( W), respectively. So far, no severe BNCT- related acute toxicities have been observed. Due to the short follow- up time, it is too early to evaluate the efficacy of these studies. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
boronophenylalanine, glioblastoma multiforme, radiation therapy, boron neutron capture therapy, BNCT, clinical, trials
in
Journal of Neurooncology
volume
62
issue
1
pages
135 - 144
publisher
Springer
external identifiers
  • wos:000182070200013
  • scopus:0037847454
ISSN
1573-7373
DOI
language
English
LU publication?
yes
id
fb645d75-bb90-4e5a-a4bb-b5c197a562e5 (old id 314888)
date added to LUP
2007-08-27 12:54:13
date last changed
2018-05-29 11:34:59
@article{fb645d75-bb90-4e5a-a4bb-b5c197a562e5,
  abstract     = {A boron neutron capture therapy ( BNCT) facility has been constructed at Studsvik, Sweden. It includes two filter/ moderator configurations. One of the resulting neutron beams has been optimized for clinical irradiations with a filter/ moderator system that allows easy variation of the neutron spectrum from the thermal to the epithermal energy range. The other beam has been designed to produce a large uniform field of thermal neutrons for radiobiological research. Scientific operations of the Studsvik BNCT project are overseen by the Scientific Advisory Board comprised of representatives of major universities in Sweden. Furthermore, special task groups for clinical and preclinical studies have been formed to facilitate collaboration with academia. The clinical Phase II trials for glioblastoma are sponsored by the Swedish National Neuro- Oncology Group and, presently, involve a protocol for BNCT treatment of glioblastoma patients who have not received any therapy other than surgery. In this protocol, p- boronophenylalanine ( BPA), administered as a 6- h intravenous infusion, is used as the boron delivery agent. As of January 2002, 17 patients were treated. The 6- h infusion of 900 mg BPA/ kg body weight was shown to be safe and resulted in the average blood - boron concentration of 24 mu g/ g ( range: 15 - 32 mu g/ g) at the time of irradiation ( approximately 2 - 3 h post- infusion). Peak and average weighted radiation doses to the brain were in the ranges of 8.0 - 15.5 Gy( W) and 3.3 - 6.1 Gy( W), respectively. So far, no severe BNCT- related acute toxicities have been observed. Due to the short follow- up time, it is too early to evaluate the efficacy of these studies.},
  author       = {Capala, J and Stenstam, BH and Skold, KS and Munck af Rosenschöld, Per and Giusti, V and Persson, C and Wallin, E and Brun, A and Franzen, L and Carlsson, JO and Salford, Leif and Ceberg, Crister and Persson, Bertil R and Pellettieri, L and Henriksson, R},
  issn         = {1573-7373},
  keyword      = {boronophenylalanine,glioblastoma multiforme,radiation therapy,boron neutron capture therapy,BNCT,clinical,trials},
  language     = {eng},
  number       = {1},
  pages        = {135--144},
  publisher    = {Springer},
  series       = {Journal of Neurooncology},
  title        = {Boron neutron capture therapy for glioblastoma multiforme: clinical studies in Sweden},
  url          = {http://dx.doi.org/},
  volume       = {62},
  year         = {2003},
}