Advanced

Accelerated Monte Carlo models to simulate fluorescence spectra from layered tissues

Swartling, Johannes LU ; Pifferi, A; Enejder, AMK and Andersson-Engels, Stefan LU (2003) In Journal of the Optical Society of America A 20(4). p.714-727
Abstract
Two efficient Monte Carlo models are described, facilitating predictions of complete time-resolved fluorescence spectra from a light-scattering and light-absorbing medium. These are compared with a third, conventional fluorescence Monte Carlo model in terms of accuracy, signal-to-noise statistics, and simulation time. The improved computation efficiency is achieved by means of a convolution technique, justified by the symmetry of the problem. Furthermore, the reciprocity principle for photon paths, employed in one of the accelerated models, is shown to simplify the computations of the distribution of the emitted fluorescence drastically. A so-called white Monte Carlo approach is finally suggested for efficient simulations of one excitation... (More)
Two efficient Monte Carlo models are described, facilitating predictions of complete time-resolved fluorescence spectra from a light-scattering and light-absorbing medium. These are compared with a third, conventional fluorescence Monte Carlo model in terms of accuracy, signal-to-noise statistics, and simulation time. The improved computation efficiency is achieved by means of a convolution technique, justified by the symmetry of the problem. Furthermore, the reciprocity principle for photon paths, employed in one of the accelerated models, is shown to simplify the computations of the distribution of the emitted fluorescence drastically. A so-called white Monte Carlo approach is finally suggested for efficient simulations of one excitation wavelength combined with a wide range of emission wavelengths. The fluorescence is simulated in a purely scattering medium, and the absorption properties are instead taken into account analytically afterward. This approach is applicable to the conventional model as well as to the two accelerated models. Essentially the same absolute values for the fluorescence integrated over the emitting surface and time are obtained for the three models within the accuracy of the simulations. The time-re solved and spatially resolved fluorescence exhibits a slight overestimation at short delay times close to the source corresponding to approximately two grid elements for the accelerated models, as a result of the discretization and the convolution. The improved efficiency is most prominent for the reverse-emission accelerated model, for which the simulation time can be reduced by up to two orders of magnitude. (C) 2003 Optical Society of America. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of the Optical Society of America A
volume
20
issue
4
pages
714 - 727
publisher
Optical Society of America
external identifiers
  • pmid:12683499
  • wos:000181881100014
  • scopus:0038476166
ISSN
1084-7529
language
English
LU publication?
yes
id
ef2ba6ad-c89f-4d6e-9686-5192369875f9 (old id 315149)
alternative location
http://www.opticsinfobase.org/abstract.cfm?URI=josaa-20-4-714
date added to LUP
2007-09-23 09:54:25
date last changed
2018-08-26 04:23:32
@article{ef2ba6ad-c89f-4d6e-9686-5192369875f9,
  abstract     = {Two efficient Monte Carlo models are described, facilitating predictions of complete time-resolved fluorescence spectra from a light-scattering and light-absorbing medium. These are compared with a third, conventional fluorescence Monte Carlo model in terms of accuracy, signal-to-noise statistics, and simulation time. The improved computation efficiency is achieved by means of a convolution technique, justified by the symmetry of the problem. Furthermore, the reciprocity principle for photon paths, employed in one of the accelerated models, is shown to simplify the computations of the distribution of the emitted fluorescence drastically. A so-called white Monte Carlo approach is finally suggested for efficient simulations of one excitation wavelength combined with a wide range of emission wavelengths. The fluorescence is simulated in a purely scattering medium, and the absorption properties are instead taken into account analytically afterward. This approach is applicable to the conventional model as well as to the two accelerated models. Essentially the same absolute values for the fluorescence integrated over the emitting surface and time are obtained for the three models within the accuracy of the simulations. The time-re solved and spatially resolved fluorescence exhibits a slight overestimation at short delay times close to the source corresponding to approximately two grid elements for the accelerated models, as a result of the discretization and the convolution. The improved efficiency is most prominent for the reverse-emission accelerated model, for which the simulation time can be reduced by up to two orders of magnitude. (C) 2003 Optical Society of America.},
  author       = {Swartling, Johannes and Pifferi, A and Enejder, AMK and Andersson-Engels, Stefan},
  issn         = {1084-7529},
  language     = {eng},
  number       = {4},
  pages        = {714--727},
  publisher    = {Optical Society of America},
  series       = {Journal of the Optical Society of America A},
  title        = {Accelerated Monte Carlo models to simulate fluorescence spectra from layered tissues},
  volume       = {20},
  year         = {2003},
}