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Expression of Cocaine- and Amphetamine-Regulated Transcript Is Associated with Worse Survival in Small Bowel Carcinoid Tumors

Landerholm, Kalle; Shcherbina, Liliya LU ; Falkmer, Sture E.; Jarhult, Johannes and Wierup, Nils LU (2012) In Clinical Cancer Research 18(13). p.3668-3676
Abstract
Purpose: Cocaine-and amphetamine-regulated transcript (CART) peptide exerts several regulatory functions acting both as neurotransmitter and hormone. We recently showed that CART is expressed in various neuroendocrine tumors, including small bowel carcinoids. The main objective of the present study was to examine whether CART expression is associated with survival in patients with small bowel carcinoid. Secondary aims were to assess whether CART expression is associated with other tumor characteristics or clinical symptoms. Experimental Design: Specimens from 97 patients with small bowel carcinoids were examined for CART expression using immunohistochemistry. A CART score was introduced on the basis of the proportion of CART immunoreactive... (More)
Purpose: Cocaine-and amphetamine-regulated transcript (CART) peptide exerts several regulatory functions acting both as neurotransmitter and hormone. We recently showed that CART is expressed in various neuroendocrine tumors, including small bowel carcinoids. The main objective of the present study was to examine whether CART expression is associated with survival in patients with small bowel carcinoid. Secondary aims were to assess whether CART expression is associated with other tumor characteristics or clinical symptoms. Experimental Design: Specimens from 97 patients with small bowel carcinoids were examined for CART expression using immunohistochemistry. A CART score was introduced on the basis of the proportion of CART immunoreactive cells. On inclusion, specimens were examined by routine histopathologic methods and detailed clinical patient data were retrieved. The effect of CART on cell viability was assessed in vitro using two intestinal tumor cell lines. Results: Expression of CART (P = 0.011) and increasing CART score (P = 0.033) were associated with worse disease-specific survival. Adjusting for age, disease stage, and tumor grade in multivariable analysis, CART expression was still associated with worse survival [Low CART HR, 5.47; 95% confidence interval (CI), 0.71-42.46; and High CART HR, 9.44; 95% CI, 1.14-78.14]. CART expression was not associated with patient age, disease stage, tumor grade, or any presenting symptom. Supporting our clinical data, we found that CART promoted tumor cell viability in vitro in two different tumor cell lines. Conclusion: Expression of CART in small bowel carcinoid tumors is associated with worse survival. Clin Cancer Res; 18(13); 3668-76. (C)2012 AACR. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Cancer Research
volume
18
issue
13
pages
3668 - 3676
publisher
American Association for Cancer Research
external identifiers
  • wos:000307502600019
  • scopus:84863301382
ISSN
1078-0432
DOI
10.1158/1078-0432.CCR-11-2513
language
English
LU publication?
yes
id
642ec79b-b32b-4071-bb52-2817c079a7e7 (old id 3152014)
date added to LUP
2012-11-01 09:35:47
date last changed
2017-01-01 03:48:58
@article{642ec79b-b32b-4071-bb52-2817c079a7e7,
  abstract     = {Purpose: Cocaine-and amphetamine-regulated transcript (CART) peptide exerts several regulatory functions acting both as neurotransmitter and hormone. We recently showed that CART is expressed in various neuroendocrine tumors, including small bowel carcinoids. The main objective of the present study was to examine whether CART expression is associated with survival in patients with small bowel carcinoid. Secondary aims were to assess whether CART expression is associated with other tumor characteristics or clinical symptoms. Experimental Design: Specimens from 97 patients with small bowel carcinoids were examined for CART expression using immunohistochemistry. A CART score was introduced on the basis of the proportion of CART immunoreactive cells. On inclusion, specimens were examined by routine histopathologic methods and detailed clinical patient data were retrieved. The effect of CART on cell viability was assessed in vitro using two intestinal tumor cell lines. Results: Expression of CART (P = 0.011) and increasing CART score (P = 0.033) were associated with worse disease-specific survival. Adjusting for age, disease stage, and tumor grade in multivariable analysis, CART expression was still associated with worse survival [Low CART HR, 5.47; 95% confidence interval (CI), 0.71-42.46; and High CART HR, 9.44; 95% CI, 1.14-78.14]. CART expression was not associated with patient age, disease stage, tumor grade, or any presenting symptom. Supporting our clinical data, we found that CART promoted tumor cell viability in vitro in two different tumor cell lines. Conclusion: Expression of CART in small bowel carcinoid tumors is associated with worse survival. Clin Cancer Res; 18(13); 3668-76. (C)2012 AACR.},
  author       = {Landerholm, Kalle and Shcherbina, Liliya and Falkmer, Sture E. and Jarhult, Johannes and Wierup, Nils},
  issn         = {1078-0432},
  language     = {eng},
  number       = {13},
  pages        = {3668--3676},
  publisher    = {American Association for Cancer Research},
  series       = {Clinical Cancer Research},
  title        = {Expression of Cocaine- and Amphetamine-Regulated Transcript Is Associated with Worse Survival in Small Bowel Carcinoid Tumors},
  url          = {http://dx.doi.org/10.1158/1078-0432.CCR-11-2513},
  volume       = {18},
  year         = {2012},
}