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Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland.

Kvist, Linus LU ; Giwercman, Yvonne LU ; Jönsson, Bo A LU ; Lindh, Christian LU ; Bonde, Jens-Peter; Toft, Gunnar; Strucinski, Pawel; Pedersen, Henning S; Zvyezday, Valentyna and Giwercman, Aleksander LU (2012) In Reproductive Toxicology
Abstract
This study investigated whether perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS), which exhibit reproductive toxicity in experimental animals, affect sperm sex chromosome ratio. The Y:X ratio was determined by fluorescence in situ hybridization. Serum concentrations of PFOA and PFOS were measured in 607 men from Greenland, Poland and Ukraine using liquid chromatography-tandem mass spectrometry. Data was analyzed by linear and nonlinear regression. We observed no associations between PFOA and Y:X ratio (p=0.845 in a linear model, p=0.296 in a nonlinear model). A positive nonlinear association between PFOS and Y:X ratio was observed (p=0.016), with no association in a linear model (p=0.118). Analyzing the populations... (More)
This study investigated whether perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS), which exhibit reproductive toxicity in experimental animals, affect sperm sex chromosome ratio. The Y:X ratio was determined by fluorescence in situ hybridization. Serum concentrations of PFOA and PFOS were measured in 607 men from Greenland, Poland and Ukraine using liquid chromatography-tandem mass spectrometry. Data was analyzed by linear and nonlinear regression. We observed no associations between PFOA and Y:X ratio (p=0.845 in a linear model, p=0.296 in a nonlinear model). A positive nonlinear association between PFOS and Y:X ratio was observed (p=0.016), with no association in a linear model (p=0.118). Analyzing the populations separately, a negative trend between categorized PFOS exposure and Y:X ratio was observed for the Inuit (B=-0.002, p=0.044). In conclusion, there was a negative trend between Y:X ratio and PFOS in the Inuit, while there was no association between PFOA and the Y:X ratio in adult men. (Less)
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published
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Reproductive Toxicology
publisher
Elsevier
external identifiers
  • wos:000312427600019
  • pmid:23044208
  • scopus:84868224674
ISSN
1873-1708
DOI
10.1016/j.reprotox.2012.09.007
language
English
LU publication?
yes
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b6fd1212-234c-4398-b6ad-5464294a7b4c (old id 3160983)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23044208?dopt=Abstract
date added to LUP
2012-11-01 15:14:04
date last changed
2017-08-20 04:05:00
@article{b6fd1212-234c-4398-b6ad-5464294a7b4c,
  abstract     = {This study investigated whether perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS), which exhibit reproductive toxicity in experimental animals, affect sperm sex chromosome ratio. The Y:X ratio was determined by fluorescence in situ hybridization. Serum concentrations of PFOA and PFOS were measured in 607 men from Greenland, Poland and Ukraine using liquid chromatography-tandem mass spectrometry. Data was analyzed by linear and nonlinear regression. We observed no associations between PFOA and Y:X ratio (p=0.845 in a linear model, p=0.296 in a nonlinear model). A positive nonlinear association between PFOS and Y:X ratio was observed (p=0.016), with no association in a linear model (p=0.118). Analyzing the populations separately, a negative trend between categorized PFOS exposure and Y:X ratio was observed for the Inuit (B=-0.002, p=0.044). In conclusion, there was a negative trend between Y:X ratio and PFOS in the Inuit, while there was no association between PFOA and the Y:X ratio in adult men.},
  author       = {Kvist, Linus and Giwercman, Yvonne and Jönsson, Bo A and Lindh, Christian and Bonde, Jens-Peter and Toft, Gunnar and Strucinski, Pawel and Pedersen, Henning S and Zvyezday, Valentyna and Giwercman, Aleksander},
  issn         = {1873-1708},
  language     = {eng},
  month        = {10},
  publisher    = {Elsevier},
  series       = {Reproductive Toxicology},
  title        = {Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland.},
  url          = {http://dx.doi.org/10.1016/j.reprotox.2012.09.007},
  year         = {2012},
}