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Cancer of unknown primary (CUP): does cause of death and family history implicate hidden phenotypically changed primaries?

Hemminki, Kari LU ; Bevier, M.; Sundquist, Jan LU and Hemminki, A. (2012) In Annals of Oncology 23(10). p.2720-2724
Abstract
Cancer of unknown primary (CUP) is diagnosed at the metastatic stage. We aimed to identify hidden primary cancers in CUP patients by comparison with cancers in family members. We take use of the fact that the cause of death in CUP patients is often coded as the cancer in the organ of fatal metastasis. Forty-one thousand five hundred and twenty-three CUP patients were identified in the Swedish Family-Cancer Database, and relative risks (RRs) were calculated for cancer in offspring when family members were diagnosed with CUP and died of the cancer diagnosed in offspring. The RR for lung cancer in offspring was 1.85 when a family member was diagnosed with CUP and died of lung cancer. Significant familial associations were found for seven... (More)
Cancer of unknown primary (CUP) is diagnosed at the metastatic stage. We aimed to identify hidden primary cancers in CUP patients by comparison with cancers in family members. We take use of the fact that the cause of death in CUP patients is often coded as the cancer in the organ of fatal metastasis. Forty-one thousand five hundred and twenty-three CUP patients were identified in the Swedish Family-Cancer Database, and relative risks (RRs) were calculated for cancer in offspring when family members were diagnosed with CUP and died of the cancer diagnosed in offspring. The RR for lung cancer in offspring was 1.85 when a family member was diagnosed with CUP and died of lung cancer. Significant familial associations were found for seven other cancers. Many familial associations were also significant when offspring CUP patients died of the cancer diagnosed in family members. The cause of death after CUP diagnosis frequently matched the cancer found in a family member, suggesting that the CUP had originated in that tissue. The metastasis had probably undergone a phenotypic change, complicating pathological tissue assignment. These novel data suggest that some CUP cases are phenotypically modified primary cancers rather than cancers of unknown primaries. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cancer of unknown primary (CUP), cancer prevention, epidemiology
in
Annals of Oncology
volume
23
issue
10
pages
2720 - 2724
publisher
Oxford University Press
external identifiers
  • wos:000309412700034
  • scopus:84867117709
ISSN
1569-8041
DOI
10.1093/annonc/mds063
language
English
LU publication?
yes
id
62387bd0-e198-412c-aba0-0bbae5447e70 (old id 3187451)
date added to LUP
2012-12-03 06:57:08
date last changed
2017-10-22 04:19:24
@article{62387bd0-e198-412c-aba0-0bbae5447e70,
  abstract     = {Cancer of unknown primary (CUP) is diagnosed at the metastatic stage. We aimed to identify hidden primary cancers in CUP patients by comparison with cancers in family members. We take use of the fact that the cause of death in CUP patients is often coded as the cancer in the organ of fatal metastasis. Forty-one thousand five hundred and twenty-three CUP patients were identified in the Swedish Family-Cancer Database, and relative risks (RRs) were calculated for cancer in offspring when family members were diagnosed with CUP and died of the cancer diagnosed in offspring. The RR for lung cancer in offspring was 1.85 when a family member was diagnosed with CUP and died of lung cancer. Significant familial associations were found for seven other cancers. Many familial associations were also significant when offspring CUP patients died of the cancer diagnosed in family members. The cause of death after CUP diagnosis frequently matched the cancer found in a family member, suggesting that the CUP had originated in that tissue. The metastasis had probably undergone a phenotypic change, complicating pathological tissue assignment. These novel data suggest that some CUP cases are phenotypically modified primary cancers rather than cancers of unknown primaries.},
  author       = {Hemminki, Kari and Bevier, M. and Sundquist, Jan and Hemminki, A.},
  issn         = {1569-8041},
  keyword      = {cancer of unknown primary (CUP),cancer prevention,epidemiology},
  language     = {eng},
  number       = {10},
  pages        = {2720--2724},
  publisher    = {Oxford University Press},
  series       = {Annals of Oncology},
  title        = {Cancer of unknown primary (CUP): does cause of death and family history implicate hidden phenotypically changed primaries?},
  url          = {http://dx.doi.org/10.1093/annonc/mds063},
  volume       = {23},
  year         = {2012},
}