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Kidney Function and White Matter Disease in Young Stroke Patients Analysis of the Stroke in Young Fabry Patients Study Population

Steinicke, Robert; Gaertner, Beate; Grittner, Ulrike; Schmidt, Wolf; Dichgans, Martin; Heuschmann, Peter U.; Tanislav, Christian; Putaala, Jukka; Kaps, Manfred and Endres, Matthias, et al. (2012) In Stroke: a journal of cerebral circulation 43(9). p.2382-2388
Abstract
Background and Purpose-Impaired kidney function is thought to be associated with small vessel disease, outcome, and mortality in the general stroke population. Data are limited regarding young patients. The aim of this study was to investigate the association of kidney function and white matter hyperintensities (WMHs) in young patients with first ischemic stroke. Methods-We analyzed 2500 young (18-55 years) patients with first-ever ischemic stroke from the prospective observational Stroke in Young Fabry Patients (SIFAP1) study with available MRI data on WMH. Of these, 2009 had available data concerning estimated glomerular filtration rate (eGFR). Kidney function was expressed as eGFR by the Modification of Diet in Renal Disease method.... (More)
Background and Purpose-Impaired kidney function is thought to be associated with small vessel disease, outcome, and mortality in the general stroke population. Data are limited regarding young patients. The aim of this study was to investigate the association of kidney function and white matter hyperintensities (WMHs) in young patients with first ischemic stroke. Methods-We analyzed 2500 young (18-55 years) patients with first-ever ischemic stroke from the prospective observational Stroke in Young Fabry Patients (SIFAP1) study with available MRI data on WMH. Of these, 2009 had available data concerning estimated glomerular filtration rate (eGFR). Kidney function was expressed as eGFR by the Modification of Diet in Renal Disease method. Deep WMHs on MRI were classified by the Fazekas score. Multivariate analysis was performed using a regression model with random effects. Results-Mean eGFR was 96.7 mL/min in those with WMH Grade 0 to 1 (none to mild), 90.7 mL/min in WMH Grade 2 (moderate), and 89 mL/min in WMH Grade 3 (severe). Univariate analysis revealed WMH to be associated with age (P<0.001), hypertension (P<0.001), cardiovascular disease (P=0.015), overweight (body mass index >25 kg/m(2); P=0.013), current smoking (P=0.044), and eGFR (P=0.009). In multivariate analysis, age, hypertension, and eGFR remained associated with WMH severity. Conclusions-In young patients with acute ischemic stroke, lower eGFR values in the normal range are associated with the presence of moderate to severe WMH. (Less)
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Contribution to journal
publication status
published
subject
keywords
estimated glomerular filtration rate (eGFR) kidney function, MRI, stroke, white matter hyperintensities (WMH)
in
Stroke: a journal of cerebral circulation
volume
43
issue
9
pages
2382 - 2388
publisher
American Heart Association
external identifiers
  • wos:000308416300034
  • scopus:84865589946
ISSN
1524-4628
DOI
10.1161/STROKEAHA.111.645713
language
English
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yes
id
54e2cb19-d242-4b93-a8e0-8a0c948bb20a (old id 3191410)
date added to LUP
2012-12-03 07:11:38
date last changed
2017-02-26 03:43:46
@article{54e2cb19-d242-4b93-a8e0-8a0c948bb20a,
  abstract     = {Background and Purpose-Impaired kidney function is thought to be associated with small vessel disease, outcome, and mortality in the general stroke population. Data are limited regarding young patients. The aim of this study was to investigate the association of kidney function and white matter hyperintensities (WMHs) in young patients with first ischemic stroke. Methods-We analyzed 2500 young (18-55 years) patients with first-ever ischemic stroke from the prospective observational Stroke in Young Fabry Patients (SIFAP1) study with available MRI data on WMH. Of these, 2009 had available data concerning estimated glomerular filtration rate (eGFR). Kidney function was expressed as eGFR by the Modification of Diet in Renal Disease method. Deep WMHs on MRI were classified by the Fazekas score. Multivariate analysis was performed using a regression model with random effects. Results-Mean eGFR was 96.7 mL/min in those with WMH Grade 0 to 1 (none to mild), 90.7 mL/min in WMH Grade 2 (moderate), and 89 mL/min in WMH Grade 3 (severe). Univariate analysis revealed WMH to be associated with age (P&lt;0.001), hypertension (P&lt;0.001), cardiovascular disease (P=0.015), overweight (body mass index &gt;25 kg/m(2); P=0.013), current smoking (P=0.044), and eGFR (P=0.009). In multivariate analysis, age, hypertension, and eGFR remained associated with WMH severity. Conclusions-In young patients with acute ischemic stroke, lower eGFR values in the normal range are associated with the presence of moderate to severe WMH.},
  author       = {Steinicke, Robert and Gaertner, Beate and Grittner, Ulrike and Schmidt, Wolf and Dichgans, Martin and Heuschmann, Peter U. and Tanislav, Christian and Putaala, Jukka and Kaps, Manfred and Endres, Matthias and Schmidt, Reinhold and Fazekas, Franz and Norrving, Bo and Rolfs, Arndt and Martus, Peter and Tatlisumak, Turgut and Enzinger, Christian and Jungehulsing, Gerhard Jan},
  issn         = {1524-4628},
  keyword      = {estimated glomerular filtration rate (eGFR) kidney function,MRI,stroke,white matter hyperintensities (WMH)},
  language     = {eng},
  number       = {9},
  pages        = {2382--2388},
  publisher    = {American Heart Association},
  series       = { Stroke: a journal of cerebral circulation},
  title        = {Kidney Function and White Matter Disease in Young Stroke Patients Analysis of the Stroke in Young Fabry Patients Study Population},
  url          = {http://dx.doi.org/10.1161/STROKEAHA.111.645713},
  volume       = {43},
  year         = {2012},
}