Hemoglobin adducts as a measure of variations in exposure to acrylamide in food and comparison to questionnaire data
Vikstrom, Anna C. ; Warholm, Margareta ; Paulsson, Birgit ; Axmon, Anna LU
; Wirfält, Elisabet
LU
and Tornqvist, Margareta
(2012)
In Food and Chemical Toxicology
50(7).
p.2531-2539
- Abstract
- Measurement of haemoglobin (Hb) adducts from acrylamide (AA) and its metabolite glycidamide (GA) is a possibility to improve the exposure assessment in epidemiological studies of AA intake from food. This study aims to clarify the reliability of Hb-adduct measurement from individual single samples for exposure assessment of dietary AA intake. The intra-individual variations of AA- and GA-adduct levels measured in blood samples collected over 20 months from 13 non-smokers were up to 2-fold and 4-fold, respectively. The corresponding interindividual variations observed between 68 non-smokers, with large differences in AA intake, were 6-fold and 8-fold, respectively. The intra-individual variation of the GA-to-AA-adduct level ratio was up to... (More)
- Measurement of haemoglobin (Hb) adducts from acrylamide (AA) and its metabolite glycidamide (GA) is a possibility to improve the exposure assessment in epidemiological studies of AA intake from food. This study aims to clarify the reliability of Hb-adduct measurement from individual single samples for exposure assessment of dietary AA intake. The intra-individual variations of AA- and GA-adduct levels measured in blood samples collected over 20 months from 13 non-smokers were up to 2-fold and 4-fold, respectively. The corresponding interindividual variations observed between 68 non-smokers, with large differences in AA intake, were 6-fold and 8-fold, respectively. The intra-individual variation of the GA-to-AA-adduct level ratio was up to 3-fold, compared to 11-fold between individuals (n = 68). From AA-adduct levels the average AA daily intake (n = 68) was calculated and compared to that estimated from dietary history methodology: 0.52 and 0.67 mu g/kg body weight and day, respectively. At an individual level the measures showed low association (Rs = 0.39). Conclusions: Dietary AA is the dominating source to measured AA-adduct levels and corresponding inter- and intra-individual variations in non-smokers. Measurements from single individual samples are useful for calculation of average M intake and its variation in a cohort, and for identification of individuals only from extreme intake groups. (C) 2012 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3191558
- author
- Vikstrom, Anna C.
; Warholm, Margareta
; Paulsson, Birgit
; Axmon, Anna
LU
; Wirfält, Elisabet
LU
and Tornqvist, Margareta
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Acrylamide, Dietary intake, Glycidamide, Dietary history methodology, Individual variation, Food frequency questionnaire
- in
- Food and Chemical Toxicology
- volume
- 50
- issue
- 7
- pages
- 2531 - 2539
- publisher
- Elsevier
- external identifiers
-
- wos:000307320200038
- scopus:84861440559
- pmid:22525869
- ISSN
- 0278-6915
- DOI
- 10.1016/j.fct.2012.04.004
- language
- English
- LU publication?
- yes
- id
- c8ff0d32-dae0-44f8-a9fe-d07ac8b36631 (old id 3191558)
- date added to LUP
- 2016-04-01 14:14:13
- date last changed
- 2022-02-19 17:50:17
@article{c8ff0d32-dae0-44f8-a9fe-d07ac8b36631,
abstract = {{Measurement of haemoglobin (Hb) adducts from acrylamide (AA) and its metabolite glycidamide (GA) is a possibility to improve the exposure assessment in epidemiological studies of AA intake from food. This study aims to clarify the reliability of Hb-adduct measurement from individual single samples for exposure assessment of dietary AA intake. The intra-individual variations of AA- and GA-adduct levels measured in blood samples collected over 20 months from 13 non-smokers were up to 2-fold and 4-fold, respectively. The corresponding interindividual variations observed between 68 non-smokers, with large differences in AA intake, were 6-fold and 8-fold, respectively. The intra-individual variation of the GA-to-AA-adduct level ratio was up to 3-fold, compared to 11-fold between individuals (n = 68). From AA-adduct levels the average AA daily intake (n = 68) was calculated and compared to that estimated from dietary history methodology: 0.52 and 0.67 mu g/kg body weight and day, respectively. At an individual level the measures showed low association (Rs = 0.39). Conclusions: Dietary AA is the dominating source to measured AA-adduct levels and corresponding inter- and intra-individual variations in non-smokers. Measurements from single individual samples are useful for calculation of average M intake and its variation in a cohort, and for identification of individuals only from extreme intake groups. (C) 2012 Elsevier Ltd. All rights reserved.}},
author = {{Vikstrom, Anna C. and Warholm, Margareta and Paulsson, Birgit and Axmon, Anna and Wirfält, Elisabet and Tornqvist, Margareta}},
issn = {{0278-6915}},
keywords = {{Acrylamide; Dietary intake; Glycidamide; Dietary history methodology; Individual variation; Food frequency questionnaire}},
language = {{eng}},
number = {{7}},
pages = {{2531--2539}},
publisher = {{Elsevier}},
series = {{Food and Chemical Toxicology}},
title = {{Hemoglobin adducts as a measure of variations in exposure to acrylamide in food and comparison to questionnaire data}},
url = {{http://dx.doi.org/10.1016/j.fct.2012.04.004}},
doi = {{10.1016/j.fct.2012.04.004}},
volume = {{50}},
year = {{2012}},
}