Inventory of Novel Animal Models Addressing Etiology of Preeclampsia in the Development of New Therapeutic/Intervention Opportunities.
(2016) In American Journal of Reproductive Immunology 75(3). p.402-410- Abstract
- Preeclampsia is a pregnancy-related disease afflicting 3-7% of pregnancies worldwide and leads to maternal and infant morbidity and mortality. The disease is of placental origin and is commonly described as a disease of two stages. A variety of preeclampsia animal models have been proposed, but all of them have limitations in fully recapitulating the human disease. Based on the research question at hand, different or multiple models might be suitable. Multiple animal models in combination with in vitro or ex vivo studies on human placenta together offer a synergistic platform to further our understanding of the etiology of preeclampsia and potential therapeutic interventions. The described animal models of preeclampsia divide into four... (More)
- Preeclampsia is a pregnancy-related disease afflicting 3-7% of pregnancies worldwide and leads to maternal and infant morbidity and mortality. The disease is of placental origin and is commonly described as a disease of two stages. A variety of preeclampsia animal models have been proposed, but all of them have limitations in fully recapitulating the human disease. Based on the research question at hand, different or multiple models might be suitable. Multiple animal models in combination with in vitro or ex vivo studies on human placenta together offer a synergistic platform to further our understanding of the etiology of preeclampsia and potential therapeutic interventions. The described animal models of preeclampsia divide into four categories (i) spontaneous, (ii) surgically induced, (iii) pharmacologically/substance induced, and (iv) transgenic. This review aims at providing an inventory of novel models addressing etiology of the disease and or therapeutic/intervention opportunities. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8504174
- author
- Erlandsson, Lena LU ; Nääv, Åsa LU ; Hennessy, Annemarie ; Vaiman, Daniel ; Gram, Magnus LU ; Åkerström, Bo LU and Hansson, Stefan LU
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Journal of Reproductive Immunology
- volume
- 75
- issue
- 3
- pages
- 402 - 410
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:26685057
- wos:000370158300023
- pmid:26685057
- scopus:84977555077
- ISSN
- 1600-0897
- DOI
- 10.1111/aji.12460
- language
- English
- LU publication?
- yes
- id
- 3192842c-c1ec-4126-b229-3bae300f770f (old id 8504174)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26685057?dopt=Abstract
- date added to LUP
- 2016-04-04 08:55:01
- date last changed
- 2022-03-15 17:05:44
@article{3192842c-c1ec-4126-b229-3bae300f770f, abstract = {{Preeclampsia is a pregnancy-related disease afflicting 3-7% of pregnancies worldwide and leads to maternal and infant morbidity and mortality. The disease is of placental origin and is commonly described as a disease of two stages. A variety of preeclampsia animal models have been proposed, but all of them have limitations in fully recapitulating the human disease. Based on the research question at hand, different or multiple models might be suitable. Multiple animal models in combination with in vitro or ex vivo studies on human placenta together offer a synergistic platform to further our understanding of the etiology of preeclampsia and potential therapeutic interventions. The described animal models of preeclampsia divide into four categories (i) spontaneous, (ii) surgically induced, (iii) pharmacologically/substance induced, and (iv) transgenic. This review aims at providing an inventory of novel models addressing etiology of the disease and or therapeutic/intervention opportunities.}}, author = {{Erlandsson, Lena and Nääv, Åsa and Hennessy, Annemarie and Vaiman, Daniel and Gram, Magnus and Åkerström, Bo and Hansson, Stefan}}, issn = {{1600-0897}}, language = {{eng}}, number = {{3}}, pages = {{402--410}}, publisher = {{Wiley-Blackwell}}, series = {{American Journal of Reproductive Immunology}}, title = {{Inventory of Novel Animal Models Addressing Etiology of Preeclampsia in the Development of New Therapeutic/Intervention Opportunities.}}, url = {{https://lup.lub.lu.se/search/files/8167531/5208420_.pdf}}, doi = {{10.1111/aji.12460}}, volume = {{75}}, year = {{2016}}, }