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Echocardiographic right ventricular strain from multiple apical views is superior for assessment of right ventricular systolic function

Werther Evaldsson, A. LU orcid ; Ingvarsson, A. LU orcid ; Smith, J. G. LU orcid ; Rådegran, G. LU ; Roijer, A. LU ; Waktare, J. ; Ostenfeld, E. LU orcid and Meurling, C. LU (2019) In Clinical Physiology and Functional Imaging 39(2). p.168-176
Abstract

Background: Right ventricular (RV) systolic function is an important determinant of outcome in patients with pulmonary hypertension (PH). Conventional echocardiographic measures of RV are mainly based on longitudinal contractility. Recently, measurement of RV global longitudinal strain derived from multiple windows (RVGLS) has emerged as an option but has not been well evaluated. The aim of the present study was to evaluate which echocardiographic RV function parameter correlates best with RV ejection fraction derived from cardiac magnetic resonance imaging (RVEFCMR). Methods and results: Fifty-five patients evaluated for PH underwent RV assessment with echocardiography and CMR. Conventional echocardiographic parameters of RV... (More)

Background: Right ventricular (RV) systolic function is an important determinant of outcome in patients with pulmonary hypertension (PH). Conventional echocardiographic measures of RV are mainly based on longitudinal contractility. Recently, measurement of RV global longitudinal strain derived from multiple windows (RVGLS) has emerged as an option but has not been well evaluated. The aim of the present study was to evaluate which echocardiographic RV function parameter correlates best with RV ejection fraction derived from cardiac magnetic resonance imaging (RVEFCMR). Methods and results: Fifty-five patients evaluated for PH underwent RV assessment with echocardiography and CMR. Conventional echocardiographic parameters of RV function including tricuspid annular plane systolic excursion (TAPSE), tricuspid annular systolic velocity (S′), RV fractional area change (RVFAC) and RV index of myocardial performance (RIMP). RVGLS was measured from three separate apical views using a 17-segment model and strain from the lateral free wall was calculated separately (RVfree). The study included 55 patients, whereas assessment of RVGLS could be obtained in 29 patients. The Pearson correlation coefficient with RVEFCMR was strong for RVGLS (r = 0·814, P<0·001) and RVfree (r = 0·778, P<0·001), modest for RVFAC (r = 0·681, P<0·001), TAPSE (r = 0·592, P<0·001) and RIMP (r=−0·521, P<0·01), and weak for S′ (r = 0·385, P<0·01). Conclusion: The echocardiographic RV measures, RVGLS and RVfree correlated well with RVEFCMR, whereas correlation with TAPSE, RIMP and S′ was unsatisfactory. Our findings suggest that RVGLS and RVfree are the preferred echocardiographic methods for clinical practice. RVfree is easiest to perform but RVGLS could provide incremental value in selected patients.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
right ventricular bullseye plot, right ventricular ejection fraction, right ventricular global longitudinal strain, right ventricular systolic function, speckle tracking
in
Clinical Physiology and Functional Imaging
volume
39
issue
2
pages
168 - 176
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85055643785
  • pmid:30375714
ISSN
1475-0961
DOI
10.1111/cpf.12552
language
English
LU publication?
yes
id
31a86e6b-d6c8-43ba-956b-3a61b6522001
date added to LUP
2018-11-20 11:05:19
date last changed
2024-10-01 10:38:20
@article{31a86e6b-d6c8-43ba-956b-3a61b6522001,
  abstract     = {{<p>Background: Right ventricular (RV) systolic function is an important determinant of outcome in patients with pulmonary hypertension (PH). Conventional echocardiographic measures of RV are mainly based on longitudinal contractility. Recently, measurement of RV global longitudinal strain derived from multiple windows (RVGLS) has emerged as an option but has not been well evaluated. The aim of the present study was to evaluate which echocardiographic RV function parameter correlates best with RV ejection fraction derived from cardiac magnetic resonance imaging (RVEF<sub>CMR</sub>). Methods and results: Fifty-five patients evaluated for PH underwent RV assessment with echocardiography and CMR. Conventional echocardiographic parameters of RV function including tricuspid annular plane systolic excursion (TAPSE), tricuspid annular systolic velocity (S′), RV fractional area change (RVFAC) and RV index of myocardial performance (RIMP). RVGLS was measured from three separate apical views using a 17-segment model and strain from the lateral free wall was calculated separately (RVfree). The study included 55 patients, whereas assessment of RVGLS could be obtained in 29 patients. The Pearson correlation coefficient with RVEF<sub>CMR</sub> was strong for RVGLS (r = 0·814, P&lt;0·001) and RVfree (r = 0·778, P&lt;0·001), modest for RVFAC (r = 0·681, P&lt;0·001), TAPSE (r = 0·592, P&lt;0·001) and RIMP (r=−0·521, P&lt;0·01), and weak for S′ (r = 0·385, P&lt;0·01). Conclusion: The echocardiographic RV measures, RVGLS and RVfree correlated well with RVEF<sub>CMR</sub>, whereas correlation with TAPSE, RIMP and S′ was unsatisfactory. Our findings suggest that RVGLS and RVfree are the preferred echocardiographic methods for clinical practice. RVfree is easiest to perform but RVGLS could provide incremental value in selected patients.</p>}},
  author       = {{Werther Evaldsson, A. and Ingvarsson, A. and Smith, J. G. and Rådegran, G. and Roijer, A. and Waktare, J. and Ostenfeld, E. and Meurling, C.}},
  issn         = {{1475-0961}},
  keywords     = {{right ventricular bullseye plot; right ventricular ejection fraction; right ventricular global longitudinal strain; right ventricular systolic function; speckle tracking}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{168--176}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Clinical Physiology and Functional Imaging}},
  title        = {{Echocardiographic right ventricular strain from multiple apical views is superior for assessment of right ventricular systolic function}},
  url          = {{http://dx.doi.org/10.1111/cpf.12552}},
  doi          = {{10.1111/cpf.12552}},
  volume       = {{39}},
  year         = {{2019}},
}