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Repair of the peripheral nerve-remyelination that works

Svennigsen, Åsa Fex and Dahlin, Lars B. LU (2013) In Brain Sciences 3(3). p.1182-1197
Abstract

In this review we summarize the events known to occur after an injury in the peripheral nervous system. We have focused on the Schwann cells, as they are the most important cells for the repair process and facilitate axonal outgrowth. The environment created by this cell type is essential for the outcome of the repair process. The review starts with a description of the current state of knowledge about the initial events after injury, followed by Wallerian degeneration, and subsequent regeneration. The importance of surgical repair, carried out as soon as possible to increase the chances of a good outcome, is emphasized throughout the review. The review concludes by describing the target re-innervation, which today is one of the most... (More)

In this review we summarize the events known to occur after an injury in the peripheral nervous system. We have focused on the Schwann cells, as they are the most important cells for the repair process and facilitate axonal outgrowth. The environment created by this cell type is essential for the outcome of the repair process. The review starts with a description of the current state of knowledge about the initial events after injury, followed by Wallerian degeneration, and subsequent regeneration. The importance of surgical repair, carried out as soon as possible to increase the chances of a good outcome, is emphasized throughout the review. The review concludes by describing the target re-innervation, which today is one of the most serious problems for nerve regeneration. It is clear, compiling this data, that even though regeneration of the peripheral nervous system is possible, more research in this area is needed in order to perfect the outcome.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bands of büngner, Myelination, Nerve regeneration, Nerve repair, Peripheral nerve injury, Proliferation, Schwann cell, Target innervation
in
Brain Sciences
volume
3
issue
3
pages
1182 - 1197
publisher
Multidisciplinary Digital Publishing Institute (MDPI)
external identifiers
  • scopus:84905824388
DOI
10.3390/brainsci3031182
language
English
LU publication?
yes
id
31eea7af-8b5c-4c00-aadb-aac7f38d4edf
date added to LUP
2019-06-17 14:27:07
date last changed
2019-07-29 14:10:07
@article{31eea7af-8b5c-4c00-aadb-aac7f38d4edf,
  abstract     = {<p>In this review we summarize the events known to occur after an injury in the peripheral nervous system. We have focused on the Schwann cells, as they are the most important cells for the repair process and facilitate axonal outgrowth. The environment created by this cell type is essential for the outcome of the repair process. The review starts with a description of the current state of knowledge about the initial events after injury, followed by Wallerian degeneration, and subsequent regeneration. The importance of surgical repair, carried out as soon as possible to increase the chances of a good outcome, is emphasized throughout the review. The review concludes by describing the target re-innervation, which today is one of the most serious problems for nerve regeneration. It is clear, compiling this data, that even though regeneration of the peripheral nervous system is possible, more research in this area is needed in order to perfect the outcome.</p>},
  author       = {Svennigsen, Åsa Fex and Dahlin, Lars B.},
  keyword      = {Bands of büngner,Myelination,Nerve regeneration,Nerve repair,Peripheral nerve injury,Proliferation,Schwann cell,Target innervation},
  language     = {eng},
  month        = {01},
  number       = {3},
  pages        = {1182--1197},
  publisher    = {Multidisciplinary Digital Publishing Institute (MDPI)},
  series       = {Brain Sciences},
  title        = {Repair of the peripheral nerve-remyelination that works},
  url          = {http://dx.doi.org/10.3390/brainsci3031182},
  volume       = {3},
  year         = {2013},
}