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Regulation of apical growth and hyphal branching in Streptomyces

Flärdh, Klas LU ; Richards, David M; Hempel, Antje M; Howard, Martin and Buttner, Mark J (2012) In Current Opinion in Microbiology 15(6). p.737-743
Abstract
The filamentous bacteria Streptomyces grow by tip extension and through the initiation of new branches, and this apical growth is directed by a polarisome-like complex involving the essential polarity protein DivIVA. New branch sites must be marked de novo and, until recently, there was no understanding of how these new sites are selected. Equally, hyphal branching patterns are affected by environmental conditions, but there was no insight into how polar growth and hyphal branching might be regulated in response to external or internal cues. This review focuses on recent discoveries that reveal the principal mechanism of branch site selection in Streptomyces, and the first mechanism to be identified that regulates polarisome behaviour to... (More)
The filamentous bacteria Streptomyces grow by tip extension and through the initiation of new branches, and this apical growth is directed by a polarisome-like complex involving the essential polarity protein DivIVA. New branch sites must be marked de novo and, until recently, there was no understanding of how these new sites are selected. Equally, hyphal branching patterns are affected by environmental conditions, but there was no insight into how polar growth and hyphal branching might be regulated in response to external or internal cues. This review focuses on recent discoveries that reveal the principal mechanism of branch site selection in Streptomyces, and the first mechanism to be identified that regulates polarisome behaviour to modulate polar growth and hyphal branching. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Microbiology
volume
15
issue
6
pages
737 - 743
publisher
Elsevier
external identifiers
  • wos:000313612200016
  • pmid:23153774
  • scopus:84872277207
ISSN
1879-0364
DOI
10.1016/j.mib.2012.10.012
language
English
LU publication?
yes
id
2c69519c-8ad8-4857-af74-88591cbbb8bd (old id 3218936)
date added to LUP
2012-12-18 13:32:31
date last changed
2017-10-01 03:28:07
@article{2c69519c-8ad8-4857-af74-88591cbbb8bd,
  abstract     = {The filamentous bacteria Streptomyces grow by tip extension and through the initiation of new branches, and this apical growth is directed by a polarisome-like complex involving the essential polarity protein DivIVA. New branch sites must be marked de novo and, until recently, there was no understanding of how these new sites are selected. Equally, hyphal branching patterns are affected by environmental conditions, but there was no insight into how polar growth and hyphal branching might be regulated in response to external or internal cues. This review focuses on recent discoveries that reveal the principal mechanism of branch site selection in Streptomyces, and the first mechanism to be identified that regulates polarisome behaviour to modulate polar growth and hyphal branching.},
  author       = {Flärdh, Klas and Richards, David M and Hempel, Antje M and Howard, Martin and Buttner, Mark J},
  issn         = {1879-0364},
  language     = {eng},
  number       = {6},
  pages        = {737--743},
  publisher    = {Elsevier},
  series       = {Current Opinion in Microbiology},
  title        = {Regulation of apical growth and hyphal branching in Streptomyces},
  url          = {http://dx.doi.org/10.1016/j.mib.2012.10.012},
  volume       = {15},
  year         = {2012},
}