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Net portal absorption of enterally fed alpha-ketoglutarate is limited in young pigs

Lambert, BD; Stoll, B; Niinikoski, H; Pierzynowski, Stefan LU and Burrin, DG (2002) In Journal of Nutrition 132(11). p.3383-3386
Abstract
Our aim was to quantify the intestinal metabolic fate of dietary alpha-ketoglutarate (AKG). Female pigs In = 6; 21 d old) were implanted with arterial, venous, portal and gastric catheters and an ultrasonic portal flow probe and fed a corn and soybean meal-based diet. On (t)he day of the experiment, the pigs received a 4-h intragastric infusion of sodium AKG at a rate equivalent to 0, 2.5, 5 or 10% of dietary intake. The net portal AKG balance of the control and 2.5% treatments did not differ and were not different from zero. However, the net portal AKG balance of both the 5 [163 mumol/(kg (.) h)] and 10% [159 mumol/(kg (.) h)] treatments were greater (P < 0.05) than the control. Despite significant net AKG absorption at the 5 and 10%... (More)
Our aim was to quantify the intestinal metabolic fate of dietary alpha-ketoglutarate (AKG). Female pigs In = 6; 21 d old) were implanted with arterial, venous, portal and gastric catheters and an ultrasonic portal flow probe and fed a corn and soybean meal-based diet. On (t)he day of the experiment, the pigs received a 4-h intragastric infusion of sodium AKG at a rate equivalent to 0, 2.5, 5 or 10% of dietary intake. The net portal AKG balance of the control and 2.5% treatments did not differ and were not different from zero. However, the net portal AKG balance of both the 5 [163 mumol/(kg (.) h)] and 10% [159 mumol/(kg (.) h)] treatments were greater (P < 0.05) than the control. Despite significant net AKG absorption at the 5 and 10% levels, the net portal appearance represented only 10.8 and 6.7%, respectively, of the enteral input. The net portal appearances of glutamate, glutamine, ammonia and the branched-chain amino acids were not affected by dietary AKG level. We conclude that the absorption of dietary AKG is limited in young pigs and does not change the net portal balance of amino acids or ammonia. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dicarboxylic acid, glutamate dehydrogenase, glutamate, ammonia, transport, pigs
in
Journal of Nutrition
volume
132
issue
11
pages
3383 - 3386
publisher
American Society for Nutrition
external identifiers
  • pmid:12421855
  • wos:000179109300022
ISSN
1541-6100
language
English
LU publication?
yes
id
c32ef373-f45a-453c-953a-edb6de9c2fe6 (old id 324197)
date added to LUP
2007-11-07 15:47:56
date last changed
2016-04-15 19:25:21
@article{c32ef373-f45a-453c-953a-edb6de9c2fe6,
  abstract     = {Our aim was to quantify the intestinal metabolic fate of dietary alpha-ketoglutarate (AKG). Female pigs In = 6; 21 d old) were implanted with arterial, venous, portal and gastric catheters and an ultrasonic portal flow probe and fed a corn and soybean meal-based diet. On (t)he day of the experiment, the pigs received a 4-h intragastric infusion of sodium AKG at a rate equivalent to 0, 2.5, 5 or 10% of dietary intake. The net portal AKG balance of the control and 2.5% treatments did not differ and were not different from zero. However, the net portal AKG balance of both the 5 [163 mumol/(kg (.) h)] and 10% [159 mumol/(kg (.) h)] treatments were greater (P &lt; 0.05) than the control. Despite significant net AKG absorption at the 5 and 10% levels, the net portal appearance represented only 10.8 and 6.7%, respectively, of the enteral input. The net portal appearances of glutamate, glutamine, ammonia and the branched-chain amino acids were not affected by dietary AKG level. We conclude that the absorption of dietary AKG is limited in young pigs and does not change the net portal balance of amino acids or ammonia.},
  author       = {Lambert, BD and Stoll, B and Niinikoski, H and Pierzynowski, Stefan and Burrin, DG},
  issn         = {1541-6100},
  keyword      = {dicarboxylic acid,glutamate dehydrogenase,glutamate,ammonia,transport,pigs},
  language     = {eng},
  number       = {11},
  pages        = {3383--3386},
  publisher    = {American Society for Nutrition},
  series       = {Journal of Nutrition},
  title        = {Net portal absorption of enterally fed alpha-ketoglutarate is limited in young pigs},
  volume       = {132},
  year         = {2002},
}