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Alcohol consumption and mortality in individuals with diabetes mellitus

Sluik, Diewertje; Boeing, Heiner; Bergmann, Manuela M.; Schuetze, Madlen; Teucher, Birgit; Kaaks, Rudolf; Tjonneland, Anne; Overvad, Kim; Arriola, Larraitz and Ardanaz, Eva, et al. (2012) In British Journal of Nutrition 108(7). p.1307-1315
Abstract
Studies have suggested that moderate alcohol consumption is associated with a reduced risk of CVD and premature mortality in individuals with diabetes mellitus. However, history of alcohol consumption has hardly been taken into account. We investigated the association between current alcohol consumption and mortality in men and women with diabetes mellitus accounting for past alcohol consumption. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), a cohort was defined of 4797 participants with a confirmed diagnosis of diabetes mellitus. Men and women were assigned to categories of baseline and past alcohol consumption. Hazard ratios (HR) and 95% CI for total mortality were estimated with multivariable Cox... (More)
Studies have suggested that moderate alcohol consumption is associated with a reduced risk of CVD and premature mortality in individuals with diabetes mellitus. However, history of alcohol consumption has hardly been taken into account. We investigated the association between current alcohol consumption and mortality in men and women with diabetes mellitus accounting for past alcohol consumption. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), a cohort was defined of 4797 participants with a confirmed diagnosis of diabetes mellitus. Men and women were assigned to categories of baseline and past alcohol consumption. Hazard ratios (HR) and 95% CI for total mortality were estimated with multivariable Cox regression models, using light alcohol consumption (>0-6 g/d) as the reference category. Compared with light alcohol consumption, no relationship was observed between consumption of 6 g/d or more and total mortality. HR for >6.12 g/d was 0.89(95% CI 0.61, 1.30) in men and 0.86(95% CI 0.46, 1.60) in women. Adjustment for past alcohol consumption did not change the estimates substantially. In individuals who at baseline reported abstaining from alcohol, mortality rates were increased relative to light consumers: HR was 1.52 (95% CI 0.99, 2.35) in men and 1.81 (95% CI 1.04, 3.17) in women. The present study in diabetic individuals showed no association between current alcohol consumption >6 g/d and mortality risk compared with light consumption. The increased mortality risk among non-consumers appeared to be affected by their past alcohol consumption rather than their current abstinence. (Less)
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@article{cdbf7265-bdd2-4544-9206-0186ef15282a,
  abstract     = {Studies have suggested that moderate alcohol consumption is associated with a reduced risk of CVD and premature mortality in individuals with diabetes mellitus. However, history of alcohol consumption has hardly been taken into account. We investigated the association between current alcohol consumption and mortality in men and women with diabetes mellitus accounting for past alcohol consumption. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), a cohort was defined of 4797 participants with a confirmed diagnosis of diabetes mellitus. Men and women were assigned to categories of baseline and past alcohol consumption. Hazard ratios (HR) and 95% CI for total mortality were estimated with multivariable Cox regression models, using light alcohol consumption (>0-6 g/d) as the reference category. Compared with light alcohol consumption, no relationship was observed between consumption of 6 g/d or more and total mortality. HR for >6.12 g/d was 0.89(95% CI 0.61, 1.30) in men and 0.86(95% CI 0.46, 1.60) in women. Adjustment for past alcohol consumption did not change the estimates substantially. In individuals who at baseline reported abstaining from alcohol, mortality rates were increased relative to light consumers: HR was 1.52 (95% CI 0.99, 2.35) in men and 1.81 (95% CI 1.04, 3.17) in women. The present study in diabetic individuals showed no association between current alcohol consumption >6 g/d and mortality risk compared with light consumption. The increased mortality risk among non-consumers appeared to be affected by their past alcohol consumption rather than their current abstinence.},
  author       = {Sluik, Diewertje and Boeing, Heiner and Bergmann, Manuela M. and Schuetze, Madlen and Teucher, Birgit and Kaaks, Rudolf and Tjonneland, Anne and Overvad, Kim and Arriola, Larraitz and Ardanaz, Eva and Bendinelli, Benedetta and Agnoli, Claudia and Tumino, Rosario and Ricceri, Fulvio and Mattiello, Amalia and Spijkerman, Annemieke M. W. and Beulens, Joline W. J. and Grobbee, Diederick E. and Nilsson, Peter and Melander, Olle and Franks, Paul and Rolandsson, Olov and Riboli, Elio and Gallo, Valentina and Romaguera, Dora and Noethlings, Ute},
  issn         = {1475-2662},
  keyword      = {Diabetes mellitus,Alcohol consumption,History of alcohol consumption,Mortality},
  language     = {eng},
  number       = {7},
  pages        = {1307--1315},
  publisher    = {Cambridge University Press},
  series       = {British Journal of Nutrition},
  title        = {Alcohol consumption and mortality in individuals with diabetes mellitus},
  url          = {http://dx.doi.org/10.1017/S0007114511006532},
  volume       = {108},
  year         = {2012},
}