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Sibling risk of pediatric obstructive sleep apnea syndrome and adenotonsillar hypertrophy

Friberg, Danielle; Sundquist, Jan LU ; Li, Xinjun LU ; Hemminki, Kari LU and Sundquist, Kristina LU (2009) In Sleep 32(8). p.83-1077
Abstract

OBJECTIVES: To estimate sibling risk of hospitalization for children with sleep disordered breathing (SDB), diagnosed with (1) obstructive sleep apnea syndrome (OSAS), or (2) adenotonsillar hypertrophy in the total Swedish population.

DESIGN, SETTING, AND PARTICIPANTS: Using the MigMed database at the Karolinska Institute, we divided the population of Sweden aged 0-18 years into sibling groups based on a shared mother and father and presence of a primary hospital diagnosis of OSAS or adenotonsillar hypertrophy for each individual born between 1978 and 1986, during the follow-up period 1997-2004. Individuals with at least one affected sibling were identified and the incidence rates were computed, using standardized incidence ratios... (More)

OBJECTIVES: To estimate sibling risk of hospitalization for children with sleep disordered breathing (SDB), diagnosed with (1) obstructive sleep apnea syndrome (OSAS), or (2) adenotonsillar hypertrophy in the total Swedish population.

DESIGN, SETTING, AND PARTICIPANTS: Using the MigMed database at the Karolinska Institute, we divided the population of Sweden aged 0-18 years into sibling groups based on a shared mother and father and presence of a primary hospital diagnosis of OSAS or adenotonsillar hypertrophy for each individual born between 1978 and 1986, during the follow-up period 1997-2004. Individuals with at least one affected sibling were identified and the incidence rates were computed, using standardized incidence ratios (SIRs) with 95% confidence intervals (CIs). Reference groups were boys and girls with unaffected siblings of 2 or more.

RESULTS: After accounting for socioeconomic status, age, and geographic region, boys with at least one sibling with OSAS had an increased risk of having OSAS (SIR, 33.2; 95% CI, 16.5-64.8), and in girls the SIR was 40.5 (19.4-81.4). For hypertrophy of the tonsils or hypertrophy of the adenoids and tonsils the corresponding SIRs were 4.53 (3.0-6.8) for boys and 4.94 (3.3-7.4) for girls.

CONCLUSIONS: The study indicate an increased sibling risk of sleep disordered breathing in children, which may be due to heritable genes and/or shared environment such as increased awareness among family members or referring doctors. Caregivers should ask parents if siblings have similar symptoms, and thus offer them early treatment.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adenoids/pathology, Adolescent, Child, Child, Preschool, Cross-Sectional Studies, Female, Follow-Up Studies, Genetic Predisposition to Disease/epidemiology, Health Surveys, Hospitalization, Humans, Hypertrophy, Incidence, Infant, Male, Palatine Tonsil/pathology, Risk Factors, Siblings, Sleep Apnea, Obstructive/diagnosis, Social Environment, Sweden
in
Sleep
volume
32
issue
8
pages
7 pages
publisher
Asoociated Professional Sleep Societies
external identifiers
  • scopus:70349104267
ISSN
0161-8105
language
English
LU publication?
no
id
32e6fa37-c703-47b0-9c04-7632f65320a2
alternative location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717198/
date added to LUP
2019-01-30 10:53:36
date last changed
2019-07-02 04:40:27
@article{32e6fa37-c703-47b0-9c04-7632f65320a2,
  abstract     = {<p>OBJECTIVES: To estimate sibling risk of hospitalization for children with sleep disordered breathing (SDB), diagnosed with (1) obstructive sleep apnea syndrome (OSAS), or (2) adenotonsillar hypertrophy in the total Swedish population.</p><p>DESIGN, SETTING, AND PARTICIPANTS: Using the MigMed database at the Karolinska Institute, we divided the population of Sweden aged 0-18 years into sibling groups based on a shared mother and father and presence of a primary hospital diagnosis of OSAS or adenotonsillar hypertrophy for each individual born between 1978 and 1986, during the follow-up period 1997-2004. Individuals with at least one affected sibling were identified and the incidence rates were computed, using standardized incidence ratios (SIRs) with 95% confidence intervals (CIs). Reference groups were boys and girls with unaffected siblings of 2 or more.</p><p>RESULTS: After accounting for socioeconomic status, age, and geographic region, boys with at least one sibling with OSAS had an increased risk of having OSAS (SIR, 33.2; 95% CI, 16.5-64.8), and in girls the SIR was 40.5 (19.4-81.4). For hypertrophy of the tonsils or hypertrophy of the adenoids and tonsils the corresponding SIRs were 4.53 (3.0-6.8) for boys and 4.94 (3.3-7.4) for girls.</p><p>CONCLUSIONS: The study indicate an increased sibling risk of sleep disordered breathing in children, which may be due to heritable genes and/or shared environment such as increased awareness among family members or referring doctors. Caregivers should ask parents if siblings have similar symptoms, and thus offer them early treatment.</p>},
  author       = {Friberg, Danielle and Sundquist, Jan and Li, Xinjun and Hemminki, Kari and Sundquist, Kristina},
  issn         = {0161-8105},
  keyword      = {Adenoids/pathology,Adolescent,Child,Child, Preschool,Cross-Sectional Studies,Female,Follow-Up Studies,Genetic Predisposition to Disease/epidemiology,Health Surveys,Hospitalization,Humans,Hypertrophy,Incidence,Infant,Male,Palatine Tonsil/pathology,Risk Factors,Siblings,Sleep Apnea, Obstructive/diagnosis,Social Environment,Sweden},
  language     = {eng},
  number       = {8},
  pages        = {83--1077},
  publisher    = {Asoociated Professional Sleep Societies},
  series       = {Sleep},
  title        = {Sibling risk of pediatric obstructive sleep apnea syndrome and adenotonsillar hypertrophy},
  volume       = {32},
  year         = {2009},
}