Skin hydration as a tool to control the distribution and molecular effects of intermediate polarity compounds in intact stratum corneum
(2021) In Journal of Colloid and Interface Science 603. p.874-885- Abstract
The barrier function of the skin is mainly assured by its outermost layer, stratum corneum (SC), which consists of dead keratin-filled cells embedded in a lipid matrix. The skin is daily exposed to an environment with changing conditions in terms of hydration and different chemicals. Here we investigate how a molecule that has reasonable solubility in both hydrophobic and hydrophilic environments can be directed to certain regions in SC by changing the skin hydration. We use 1,2,3-trimethoxy propane (TMP) as a model substance and solid-state NMR on natural abundance 13C to obtain atomically resolved information on the molecular dynamics of TMP as well as SC lipid and protein components at varying hydration conditions. Upon... (More)
The barrier function of the skin is mainly assured by its outermost layer, stratum corneum (SC), which consists of dead keratin-filled cells embedded in a lipid matrix. The skin is daily exposed to an environment with changing conditions in terms of hydration and different chemicals. Here we investigate how a molecule that has reasonable solubility in both hydrophobic and hydrophilic environments can be directed to certain regions in SC by changing the skin hydration. We use 1,2,3-trimethoxy propane (TMP) as a model substance and solid-state NMR on natural abundance 13C to obtain atomically resolved information on the molecular dynamics of TMP as well as SC lipid and protein components at varying hydration conditions. Upon dehydration, TMP redistributes from the hydrophilic corneocytes to the hydrophobic SC lipid regions. In this way, TMP can act to prevent the fluid–solid lipid transition in drying conditions and be present in the corneocytes in more humid conditions. Hydration can thereby be used as a switch to control the location and action of TMP or similar compounds in complex materials like SC. The general principles described here can also have impact on other applications including lipid-based formulations in food, drug delivery and cosmetics.
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- author
- Pham, Quoc Dat LU ; Gregoire, Sebastien ; Biatry, Bruno ; Cassin, Guillaume ; Topgaard, Daniel LU and Sparr, Emma LU
- organization
- publishing date
- 2021-12-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Conformation, Corneocytes, Extracellular lipids, Keratin filaments, Molecular mobility, solid-state NMR, Trimethoxy propane
- in
- Journal of Colloid and Interface Science
- volume
- 603
- pages
- 12 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85109210345
- pmid:34246090
- ISSN
- 0021-9797
- DOI
- 10.1016/j.jcis.2021.06.097
- language
- English
- LU publication?
- yes
- additional info
- Funding Information: The Swedish Research Council (VR) is gratefully acknowledged for financial support (E.S., Grant No. 2019-05296). This project has received funding from L’Oréal company.
- id
- 3324b9cc-b5d7-41e1-9f2f-a097ac051182
- date added to LUP
- 2021-08-12 10:20:55
- date last changed
- 2024-09-21 23:13:05
@article{3324b9cc-b5d7-41e1-9f2f-a097ac051182, abstract = {{<p>The barrier function of the skin is mainly assured by its outermost layer, stratum corneum (SC), which consists of dead keratin-filled cells embedded in a lipid matrix. The skin is daily exposed to an environment with changing conditions in terms of hydration and different chemicals. Here we investigate how a molecule that has reasonable solubility in both hydrophobic and hydrophilic environments can be directed to certain regions in SC by changing the skin hydration. We use 1,2,3-trimethoxy propane (TMP) as a model substance and solid-state NMR on natural abundance <sup>13</sup>C to obtain atomically resolved information on the molecular dynamics of TMP as well as SC lipid and protein components at varying hydration conditions. Upon dehydration, TMP redistributes from the hydrophilic corneocytes to the hydrophobic SC lipid regions. In this way, TMP can act to prevent the fluid–solid lipid transition in drying conditions and be present in the corneocytes in more humid conditions. Hydration can thereby be used as a switch to control the location and action of TMP or similar compounds in complex materials like SC. The general principles described here can also have impact on other applications including lipid-based formulations in food, drug delivery and cosmetics.</p>}}, author = {{Pham, Quoc Dat and Gregoire, Sebastien and Biatry, Bruno and Cassin, Guillaume and Topgaard, Daniel and Sparr, Emma}}, issn = {{0021-9797}}, keywords = {{Conformation; Corneocytes; Extracellular lipids; Keratin filaments; Molecular mobility; solid-state NMR; Trimethoxy propane}}, language = {{eng}}, month = {{12}}, pages = {{874--885}}, publisher = {{Elsevier}}, series = {{Journal of Colloid and Interface Science}}, title = {{Skin hydration as a tool to control the distribution and molecular effects of intermediate polarity compounds in intact stratum corneum}}, url = {{http://dx.doi.org/10.1016/j.jcis.2021.06.097}}, doi = {{10.1016/j.jcis.2021.06.097}}, volume = {{603}}, year = {{2021}}, }