Advanced

Photon activation therapy of RG2 glioma carrying Fischer rats using stable thallium and monochromatic synchrotron radiation.

Ceberg, Crister LU ; Jönsson, Bo-Anders LU ; Prezado, Yolanda; Pommer, Tobias; Nittby, Henrietta LU ; Englund, Elisabet LU ; Grafström, Gustav LU ; Edvardsson, Anneli LU ; Stenvall, Anna LU and Strömblad, Susanne LU , et al. (2012) In Physics in Medicine and Biology 57(24). p.8377-8391
Abstract
75 RG2 glioma-carrying Fischer rats were treated by photon activation therapy (PAT) with monochromatic synchrotron radiation and stable thallium. Three groups were treated with thallium in combination with radiation at different energy; immediately below and above the thallium K-edge, and at 50 keV. Three control groups were given irradiation only, thallium only, or no treatment at all. For animals receiving thallium in combination with radiation to 15 Gy at 50 keV, the median survival time was 30 days, which was 67% longer than for the untreated controls (p = 0.0020) and 36% longer than for the group treated with radiation alone (not significant). Treatment with thallium and radiation at the higher energy levels were not effective at the... (More)
75 RG2 glioma-carrying Fischer rats were treated by photon activation therapy (PAT) with monochromatic synchrotron radiation and stable thallium. Three groups were treated with thallium in combination with radiation at different energy; immediately below and above the thallium K-edge, and at 50 keV. Three control groups were given irradiation only, thallium only, or no treatment at all. For animals receiving thallium in combination with radiation to 15 Gy at 50 keV, the median survival time was 30 days, which was 67% longer than for the untreated controls (p = 0.0020) and 36% longer than for the group treated with radiation alone (not significant). Treatment with thallium and radiation at the higher energy levels were not effective at the given absorbed dose and thallium concentration. In the groups treated at 50 keV and above the K-edge, several animals exhibited extensive and sometimes contra-lateral edema, neuronal death and frank tissue necrosis. No such marked changes were seen in the other groups. The results were discussed with reference to Monte Carlo calculated electron energy spectra and dose enhancement factors. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physics in Medicine and Biology
volume
57
issue
24
pages
8377 - 8391
publisher
IOP Publishing
external identifiers
  • wos:000312106200017
  • pmid:23201928
  • scopus:84871256382
ISSN
1361-6560
DOI
10.1088/0031-9155/57/24/8377
language
English
LU publication?
yes
id
e2371a3d-10c0-47d0-adb8-5de26db587fe (old id 3347750)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23201928?dopt=Abstract
date added to LUP
2013-01-02 10:42:55
date last changed
2017-06-18 04:38:11
@article{e2371a3d-10c0-47d0-adb8-5de26db587fe,
  abstract     = {75 RG2 glioma-carrying Fischer rats were treated by photon activation therapy (PAT) with monochromatic synchrotron radiation and stable thallium. Three groups were treated with thallium in combination with radiation at different energy; immediately below and above the thallium K-edge, and at 50 keV. Three control groups were given irradiation only, thallium only, or no treatment at all. For animals receiving thallium in combination with radiation to 15 Gy at 50 keV, the median survival time was 30 days, which was 67% longer than for the untreated controls (p = 0.0020) and 36% longer than for the group treated with radiation alone (not significant). Treatment with thallium and radiation at the higher energy levels were not effective at the given absorbed dose and thallium concentration. In the groups treated at 50 keV and above the K-edge, several animals exhibited extensive and sometimes contra-lateral edema, neuronal death and frank tissue necrosis. No such marked changes were seen in the other groups. The results were discussed with reference to Monte Carlo calculated electron energy spectra and dose enhancement factors.},
  author       = {Ceberg, Crister and Jönsson, Bo-Anders and Prezado, Yolanda and Pommer, Tobias and Nittby, Henrietta and Englund, Elisabet and Grafström, Gustav and Edvardsson, Anneli and Stenvall, Anna and Strömblad, Susanne and Wingårdh, Karin and Persson, Bertil R and Elleaume, Hélène and Baldetorp, Bo and Salford, Leif and Strand, Sven-Erik},
  issn         = {1361-6560},
  language     = {eng},
  number       = {24},
  pages        = {8377--8391},
  publisher    = {IOP Publishing},
  series       = {Physics in Medicine and Biology},
  title        = {Photon activation therapy of RG2 glioma carrying Fischer rats using stable thallium and monochromatic synchrotron radiation.},
  url          = {http://dx.doi.org/10.1088/0031-9155/57/24/8377},
  volume       = {57},
  year         = {2012},
}