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Cerebral perfusion deficits in age-associated memory impairment. The role of tobacco smoking

Siennicki-Lantz, Arkadiusz LU ; Lilja, Bo and Elmståhl, Sölve LU (2002) In Aging clinical and experimental research 14(2). p.108-116
Abstract
Background and aims: Several studies report a high prevalence of memory complaints in the elderly, non-demented population. Since the pathogenesis and diversity of memory impairment in healthy people is still an unresolved issue, we designed our study to ascertain the occurrence of brain abnormalities in Age-Associated Memory Impairment (AAMI) by measuring regional cerebral blood flow (rCBF). Methods: Fifty-three subjects were invited to the case-control study: 26 subjects who fulfilled the AAMI criteria, and 27 controls (age, mean SD 65.8+/-7.3 us 65.5+/-6.7). rCBF was determined using (TC)-T-99m-ECD SPECT by relative measurements made in the cortical and white matter regions and in the thalamus. Results: The AAMI group us controls had... (More)
Background and aims: Several studies report a high prevalence of memory complaints in the elderly, non-demented population. Since the pathogenesis and diversity of memory impairment in healthy people is still an unresolved issue, we designed our study to ascertain the occurrence of brain abnormalities in Age-Associated Memory Impairment (AAMI) by measuring regional cerebral blood flow (rCBF). Methods: Fifty-three subjects were invited to the case-control study: 26 subjects who fulfilled the AAMI criteria, and 27 controls (age, mean SD 65.8+/-7.3 us 65.5+/-6.7). rCBF was determined using (TC)-T-99m-ECD SPECT by relative measurements made in the cortical and white matter regions and in the thalamus. Results: The AAMI group us controls had restricted rCBF in the temporal lobe of the left hemisphere (median; 85.8 us 87.8, p=0.04), in the thalamus (median: 87.3 us 89.8, p=0.036) and the frontal white matter (median; right hemisphere 80.0 us 84.1, p=0.01; left hemisphere 77.7 us 81.6, p=0.04). AAMI subjects who previously smoked had lower rCBF values in the temporal, parietal, occipital and frontal lobes bilaterally, and poorer memory test results than ex-smoker controls. By contrast, rCBF did not differ between non-smoking AAMI subjects and controls. Conclusions: Compared to controls, AAMI subjects had restricted rCBF. A history of previous smoking could partly contribute to the rCBF differences between these groups. Further studies on failing memory and rCBF in representative cohorts of smoking and non-smoking populations are now needed. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cerebral blood flow, age-asscciated memory impairment (AAMI), aging, memory, smoking
in
Aging clinical and experimental research
volume
14
issue
2
pages
108 - 116
publisher
Kurtis
external identifiers
  • wos:000176157300004
  • pmid:12092784
  • scopus:0036019022
ISSN
1720-8319
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Geriatric Medicine (013040040), Neurology, Lund (013027000), Clinical Physiology (013242300)
id
ab2eb224-7566-4569-9223-ada3f2a64db2 (old id 335627)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12092784&dopt=Abstract
date added to LUP
2016-04-01 16:16:30
date last changed
2020-04-28 12:19:48
@article{ab2eb224-7566-4569-9223-ada3f2a64db2,
  abstract     = {Background and aims: Several studies report a high prevalence of memory complaints in the elderly, non-demented population. Since the pathogenesis and diversity of memory impairment in healthy people is still an unresolved issue, we designed our study to ascertain the occurrence of brain abnormalities in Age-Associated Memory Impairment (AAMI) by measuring regional cerebral blood flow (rCBF). Methods: Fifty-three subjects were invited to the case-control study: 26 subjects who fulfilled the AAMI criteria, and 27 controls (age, mean SD 65.8+/-7.3 us 65.5+/-6.7). rCBF was determined using (TC)-T-99m-ECD SPECT by relative measurements made in the cortical and white matter regions and in the thalamus. Results: The AAMI group us controls had restricted rCBF in the temporal lobe of the left hemisphere (median; 85.8 us 87.8, p=0.04), in the thalamus (median: 87.3 us 89.8, p=0.036) and the frontal white matter (median; right hemisphere 80.0 us 84.1, p=0.01; left hemisphere 77.7 us 81.6, p=0.04). AAMI subjects who previously smoked had lower rCBF values in the temporal, parietal, occipital and frontal lobes bilaterally, and poorer memory test results than ex-smoker controls. By contrast, rCBF did not differ between non-smoking AAMI subjects and controls. Conclusions: Compared to controls, AAMI subjects had restricted rCBF. A history of previous smoking could partly contribute to the rCBF differences between these groups. Further studies on failing memory and rCBF in representative cohorts of smoking and non-smoking populations are now needed.},
  author       = {Siennicki-Lantz, Arkadiusz and Lilja, Bo and Elmståhl, Sölve},
  issn         = {1720-8319},
  language     = {eng},
  number       = {2},
  pages        = {108--116},
  publisher    = {Kurtis},
  series       = {Aging clinical and experimental research},
  title        = {Cerebral perfusion deficits in age-associated memory impairment. The role of tobacco smoking},
  url          = {http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12092784&dopt=Abstract},
  volume       = {14},
  year         = {2002},
}