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Dialysis as a Novel Adjuvant Treatment for Malignant Cancers

Hobro, Sture ; Nilsson, Anders ; Sternby, Jan ; Öberg, Carl LU ; Pietras, Kristian LU orcid ; Axelson, Håkan LU ; Carneiro, Ana LU orcid ; Kinhult, Sara LU ; Christensson, Anders LU and Fors, Jonas , et al. (2022) In Cancers 14(20).
Abstract

Cancer metabolism is characterized by an increased utilization of fermentable fuels, such as glucose and glutamine, which support cancer cell survival by increasing resistance to both oxidative stress and the inherent immune system in humans. Dialysis has the power to shift the patient from a state dependent on glucose and glutamine to a ketogenic condition (KC) combined with low glutamine levels—thereby forcing ATP production through the Krebs cycle. By the force of dialysis, the cancer cells will be deprived of their preferred fermentable fuels, disrupting major metabolic pathways important for the ability of the cancer cells to survive. Dialysis has the potential to reduce glucose levels below physiological levels, concurrently... (More)

Cancer metabolism is characterized by an increased utilization of fermentable fuels, such as glucose and glutamine, which support cancer cell survival by increasing resistance to both oxidative stress and the inherent immune system in humans. Dialysis has the power to shift the patient from a state dependent on glucose and glutamine to a ketogenic condition (KC) combined with low glutamine levels—thereby forcing ATP production through the Krebs cycle. By the force of dialysis, the cancer cells will be deprived of their preferred fermentable fuels, disrupting major metabolic pathways important for the ability of the cancer cells to survive. Dialysis has the potential to reduce glucose levels below physiological levels, concurrently increase blood ketone body levels and reduce glutamine levels, which may further reinforce the impact of the KC. Importantly, ketones also induce epigenetic changes imposed by histone deacetylates (HDAC) activity (Class I and Class IIa) known to play an important role in cancer metabolism. Thus, dialysis could be an impactful and safe adjuvant treatment, sensitizing cancer cells to traditional cancer treatments (TCTs), potentially making these significantly more efficient.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cancer, chemotherapies, dialysis, HDAC, immunotherapies, ketone bodies, radiotherapies, redox balance
in
Cancers
volume
14
issue
20
article number
5054
publisher
MDPI AG
external identifiers
  • pmid:36291840
  • scopus:85140579528
ISSN
2072-6694
DOI
10.3390/cancers14205054
language
English
LU publication?
yes
id
336d85c2-3a58-49af-bc6f-3b545e909358
date added to LUP
2022-12-14 12:33:47
date last changed
2024-05-26 15:20:55
@article{336d85c2-3a58-49af-bc6f-3b545e909358,
  abstract     = {{<p>Cancer metabolism is characterized by an increased utilization of fermentable fuels, such as glucose and glutamine, which support cancer cell survival by increasing resistance to both oxidative stress and the inherent immune system in humans. Dialysis has the power to shift the patient from a state dependent on glucose and glutamine to a ketogenic condition (KC) combined with low glutamine levels—thereby forcing ATP production through the Krebs cycle. By the force of dialysis, the cancer cells will be deprived of their preferred fermentable fuels, disrupting major metabolic pathways important for the ability of the cancer cells to survive. Dialysis has the potential to reduce glucose levels below physiological levels, concurrently increase blood ketone body levels and reduce glutamine levels, which may further reinforce the impact of the KC. Importantly, ketones also induce epigenetic changes imposed by histone deacetylates (HDAC) activity (Class I and Class IIa) known to play an important role in cancer metabolism. Thus, dialysis could be an impactful and safe adjuvant treatment, sensitizing cancer cells to traditional cancer treatments (TCTs), potentially making these significantly more efficient.</p>}},
  author       = {{Hobro, Sture and Nilsson, Anders and Sternby, Jan and Öberg, Carl and Pietras, Kristian and Axelson, Håkan and Carneiro, Ana and Kinhult, Sara and Christensson, Anders and Fors, Jonas and Maciejewski, Steven and Knox, Jason and Forsal, Innas and Källquist, Linda and Roos, Viktoria}},
  issn         = {{2072-6694}},
  keywords     = {{cancer; chemotherapies; dialysis; HDAC; immunotherapies; ketone bodies; radiotherapies; redox balance}},
  language     = {{eng}},
  number       = {{20}},
  publisher    = {{MDPI AG}},
  series       = {{Cancers}},
  title        = {{Dialysis as a Novel Adjuvant Treatment for Malignant Cancers}},
  url          = {{http://dx.doi.org/10.3390/cancers14205054}},
  doi          = {{10.3390/cancers14205054}},
  volume       = {{14}},
  year         = {{2022}},
}