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Characterization of ventricular depolarization and repolarization changes in a porcine model of myocardial infarction

Romero, Daniel; Ringborn, Michael LU ; Demidova, Marina LU ; Koul, Sasha LU ; Laguna, Pablo; Platonov, Pyotr LU and Pueyo, Esther (2012) In Physiological Measurement 33(12). p.1975-1991
Abstract
In this study, several electrocardiogram (ECG)-derived indices corresponding to both ventricular depolarization and repolarization were evaluated during acute myocardial ischemia in an experimental model of myocardial infarction produced by 40 min coronary balloon inflation in 13 pigs. Significant changes were rapidly observed from minute 4 after the start of coronary occlusion, achieving their maximum values between 11 and 22 min for depolarization and between 9 and 12 min for repolarization indices, respectively. Subsequently, these maximum changes started to decrease during the latter part of the occlusion. Depolarization changes associated with the second half of the QRS complex showed a significant but inverse correlation with the... (More)
In this study, several electrocardiogram (ECG)-derived indices corresponding to both ventricular depolarization and repolarization were evaluated during acute myocardial ischemia in an experimental model of myocardial infarction produced by 40 min coronary balloon inflation in 13 pigs. Significant changes were rapidly observed from minute 4 after the start of coronary occlusion, achieving their maximum values between 11 and 22 min for depolarization and between 9 and 12 min for repolarization indices, respectively. Subsequently, these maximum changes started to decrease during the latter part of the occlusion. Depolarization changes associated with the second half of the QRS complex showed a significant but inverse correlation with the myocardium at risk (MaR) estimated by scintigraphic images. The correlation between MaR and changes of the downward slope of the QRS complex, I-DS, evaluated at the two more relevant peaks observed during the occlusion, was r = -0.75, p < 0.01 and r = -0.79, p < 0.01 for the positive and negative deflections observed in I-DS temporal evolution, respectively. Repolarization changes, analyzed by evaluation of ST segment elevation at the main observed positive peak, also showed negative, however non-significant correlation with MaR: r = -0.34, p = 0.28. Our results suggest that changes evaluated in the latter part of the depolarization, such as those described by I-DS, which are influenced by R-wave amplitude, QRS width and ST level variations simultaneously, correlate better with the amount of ischemia than other indices evaluated in the earlier part of depolarization or during the ST segment. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ischemia, PCI, depolarization, QRS slopes
in
Physiological Measurement
volume
33
issue
12
pages
1975 - 1991
publisher
IOP Publishing
external identifiers
  • wos:000311740700002
  • scopus:84869173854
ISSN
0967-3334
DOI
10.1088/0967-3334/33/12/1975
language
English
LU publication?
yes
id
345d0dde-51b1-4f3e-9c43-c81bea53aca0 (old id 3372758)
date added to LUP
2013-02-01 07:00:53
date last changed
2017-01-01 04:03:33
@article{345d0dde-51b1-4f3e-9c43-c81bea53aca0,
  abstract     = {In this study, several electrocardiogram (ECG)-derived indices corresponding to both ventricular depolarization and repolarization were evaluated during acute myocardial ischemia in an experimental model of myocardial infarction produced by 40 min coronary balloon inflation in 13 pigs. Significant changes were rapidly observed from minute 4 after the start of coronary occlusion, achieving their maximum values between 11 and 22 min for depolarization and between 9 and 12 min for repolarization indices, respectively. Subsequently, these maximum changes started to decrease during the latter part of the occlusion. Depolarization changes associated with the second half of the QRS complex showed a significant but inverse correlation with the myocardium at risk (MaR) estimated by scintigraphic images. The correlation between MaR and changes of the downward slope of the QRS complex, I-DS, evaluated at the two more relevant peaks observed during the occlusion, was r = -0.75, p &lt; 0.01 and r = -0.79, p &lt; 0.01 for the positive and negative deflections observed in I-DS temporal evolution, respectively. Repolarization changes, analyzed by evaluation of ST segment elevation at the main observed positive peak, also showed negative, however non-significant correlation with MaR: r = -0.34, p = 0.28. Our results suggest that changes evaluated in the latter part of the depolarization, such as those described by I-DS, which are influenced by R-wave amplitude, QRS width and ST level variations simultaneously, correlate better with the amount of ischemia than other indices evaluated in the earlier part of depolarization or during the ST segment.},
  author       = {Romero, Daniel and Ringborn, Michael and Demidova, Marina and Koul, Sasha and Laguna, Pablo and Platonov, Pyotr and Pueyo, Esther},
  issn         = {0967-3334},
  keyword      = {ischemia,PCI,depolarization,QRS slopes},
  language     = {eng},
  number       = {12},
  pages        = {1975--1991},
  publisher    = {IOP Publishing},
  series       = {Physiological Measurement},
  title        = {Characterization of ventricular depolarization and repolarization changes in a porcine model of myocardial infarction},
  url          = {http://dx.doi.org/10.1088/0967-3334/33/12/1975},
  volume       = {33},
  year         = {2012},
}