Upconverting nanoparticles for pre-clinical diffuse optical imaging, microscopy and sensing: Current trends and future challenges
(2013) In Laser & Photonics Reviews 7(5). p.663-697- Abstract
- Upconverting nanoparticles (UCNPs) are a class of recently developed luminescent biomarkers that - in several aspects - are superior to organic dyes and quantum dots. UCNPs can emit spectrally narrow anti-Stokes shifted light with quantum yields which greatly exceed those of two-photon dyes for fluence rates relevant for deep tissue imaging. Compared with conventionally used Stokes-shifting fluorophores, UCNP-based imaging systems can acquire completely autofluorescence-free data with superb contrast. For diffuse optical imaging, the multiphoton process involved in the upconversion process can be used to obtain images with unprecedented resolution. These unique properties make UCNPs extremely attractive in the field of biophotonics. UCNPs... (More)
- Upconverting nanoparticles (UCNPs) are a class of recently developed luminescent biomarkers that - in several aspects - are superior to organic dyes and quantum dots. UCNPs can emit spectrally narrow anti-Stokes shifted light with quantum yields which greatly exceed those of two-photon dyes for fluence rates relevant for deep tissue imaging. Compared with conventionally used Stokes-shifting fluorophores, UCNP-based imaging systems can acquire completely autofluorescence-free data with superb contrast. For diffuse optical imaging, the multiphoton process involved in the upconversion process can be used to obtain images with unprecedented resolution. These unique properties make UCNPs extremely attractive in the field of biophotonics. UCNPs have already been applied in microscopy, small-animal imaging, multi-modal imaging, highly sensitive bioassays, temperature sensing and photodynamic therapy. In this review, the current state-of-the-art UCNPs and their applications for diffuse imaging, microscopy and sensing targeted towards solving essential biological issues are discussed. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4212398
- author
- Xu, Can LU ; Zhan, Qiuqiang ; Liu, Haichun LU ; Somesfalean, Gabriel LU ; Qian, Jun ; He, Sailing and Andersson-Engels, Stefan LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Upconversion, quantum yield, photodynamic therapy, pulsed excitation
- in
- Laser & Photonics Reviews
- volume
- 7
- issue
- 5
- pages
- 663 - 697
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000326093800010
- scopus:84883155584
- ISSN
- 1863-8880
- DOI
- 10.1002/lpor.201200052
- language
- English
- LU publication?
- yes
- id
- 342ee4d5-b7f7-4899-946d-15affd8aaab3 (old id 4212398)
- date added to LUP
- 2016-04-01 11:07:48
- date last changed
- 2022-03-27 22:34:17
@article{342ee4d5-b7f7-4899-946d-15affd8aaab3, abstract = {{Upconverting nanoparticles (UCNPs) are a class of recently developed luminescent biomarkers that - in several aspects - are superior to organic dyes and quantum dots. UCNPs can emit spectrally narrow anti-Stokes shifted light with quantum yields which greatly exceed those of two-photon dyes for fluence rates relevant for deep tissue imaging. Compared with conventionally used Stokes-shifting fluorophores, UCNP-based imaging systems can acquire completely autofluorescence-free data with superb contrast. For diffuse optical imaging, the multiphoton process involved in the upconversion process can be used to obtain images with unprecedented resolution. These unique properties make UCNPs extremely attractive in the field of biophotonics. UCNPs have already been applied in microscopy, small-animal imaging, multi-modal imaging, highly sensitive bioassays, temperature sensing and photodynamic therapy. In this review, the current state-of-the-art UCNPs and their applications for diffuse imaging, microscopy and sensing targeted towards solving essential biological issues are discussed.}}, author = {{Xu, Can and Zhan, Qiuqiang and Liu, Haichun and Somesfalean, Gabriel and Qian, Jun and He, Sailing and Andersson-Engels, Stefan}}, issn = {{1863-8880}}, keywords = {{Upconversion; quantum yield; photodynamic therapy; pulsed excitation}}, language = {{eng}}, number = {{5}}, pages = {{663--697}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Laser & Photonics Reviews}}, title = {{Upconverting nanoparticles for pre-clinical diffuse optical imaging, microscopy and sensing: Current trends and future challenges}}, url = {{http://dx.doi.org/10.1002/lpor.201200052}}, doi = {{10.1002/lpor.201200052}}, volume = {{7}}, year = {{2013}}, }