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Upconverting nanoparticles for pre-clinical diffuse optical imaging, microscopy and sensing: Current trends and future challenges

Xu, Can LU ; Zhan, Qiuqiang; Liu, Haichun LU ; Somesfalean, Gabriel LU ; Qian, Jun; He, Sailing and Andersson-Engels, Stefan LU (2013) In Laser & Photonics Reviews 7(5). p.663-697
Abstract
Upconverting nanoparticles (UCNPs) are a class of recently developed luminescent biomarkers that - in several aspects - are superior to organic dyes and quantum dots. UCNPs can emit spectrally narrow anti-Stokes shifted light with quantum yields which greatly exceed those of two-photon dyes for fluence rates relevant for deep tissue imaging. Compared with conventionally used Stokes-shifting fluorophores, UCNP-based imaging systems can acquire completely autofluorescence-free data with superb contrast. For diffuse optical imaging, the multiphoton process involved in the upconversion process can be used to obtain images with unprecedented resolution. These unique properties make UCNPs extremely attractive in the field of biophotonics. UCNPs... (More)
Upconverting nanoparticles (UCNPs) are a class of recently developed luminescent biomarkers that - in several aspects - are superior to organic dyes and quantum dots. UCNPs can emit spectrally narrow anti-Stokes shifted light with quantum yields which greatly exceed those of two-photon dyes for fluence rates relevant for deep tissue imaging. Compared with conventionally used Stokes-shifting fluorophores, UCNP-based imaging systems can acquire completely autofluorescence-free data with superb contrast. For diffuse optical imaging, the multiphoton process involved in the upconversion process can be used to obtain images with unprecedented resolution. These unique properties make UCNPs extremely attractive in the field of biophotonics. UCNPs have already been applied in microscopy, small-animal imaging, multi-modal imaging, highly sensitive bioassays, temperature sensing and photodynamic therapy. In this review, the current state-of-the-art UCNPs and their applications for diffuse imaging, microscopy and sensing targeted towards solving essential biological issues are discussed. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Upconversion, quantum yield, photodynamic therapy, pulsed excitation
in
Laser & Photonics Reviews
volume
7
issue
5
pages
663 - 697
publisher
John Wiley & Sons
external identifiers
  • wos:000326093800010
  • scopus:84883155584
ISSN
1863-8880
DOI
10.1002/lpor.201200052
language
English
LU publication?
yes
id
342ee4d5-b7f7-4899-946d-15affd8aaab3 (old id 4212398)
date added to LUP
2014-01-07 11:12:16
date last changed
2019-03-05 01:35:12
@article{342ee4d5-b7f7-4899-946d-15affd8aaab3,
  abstract     = {Upconverting nanoparticles (UCNPs) are a class of recently developed luminescent biomarkers that - in several aspects - are superior to organic dyes and quantum dots. UCNPs can emit spectrally narrow anti-Stokes shifted light with quantum yields which greatly exceed those of two-photon dyes for fluence rates relevant for deep tissue imaging. Compared with conventionally used Stokes-shifting fluorophores, UCNP-based imaging systems can acquire completely autofluorescence-free data with superb contrast. For diffuse optical imaging, the multiphoton process involved in the upconversion process can be used to obtain images with unprecedented resolution. These unique properties make UCNPs extremely attractive in the field of biophotonics. UCNPs have already been applied in microscopy, small-animal imaging, multi-modal imaging, highly sensitive bioassays, temperature sensing and photodynamic therapy. In this review, the current state-of-the-art UCNPs and their applications for diffuse imaging, microscopy and sensing targeted towards solving essential biological issues are discussed.},
  author       = {Xu, Can and Zhan, Qiuqiang and Liu, Haichun and Somesfalean, Gabriel and Qian, Jun and He, Sailing and Andersson-Engels, Stefan},
  issn         = {1863-8880},
  keyword      = {Upconversion,quantum yield,photodynamic therapy,pulsed excitation},
  language     = {eng},
  number       = {5},
  pages        = {663--697},
  publisher    = {John Wiley & Sons},
  series       = {Laser & Photonics Reviews},
  title        = {Upconverting nanoparticles for pre-clinical diffuse optical imaging, microscopy and sensing: Current trends and future challenges},
  url          = {http://dx.doi.org/10.1002/lpor.201200052},
  volume       = {7},
  year         = {2013},
}