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Biologically active secondary metabolites from the ascomycete A111-95 - 1. Production, isolation and biological activities

Kopcke, B; Johansson, M; Sterner, Olov LU and Anke, H (2002) In Journal of Antibiotics 55(1). p.36-40
Abstract
Eight secondary metabolites were isolated from submerged cultures of the ascomycete A111-95 during a search for new nematicidal metabolites. (-)-Galiellalactone (7) and compound 2 are metabolites previously obtained from cultures of Galiella rufa while the compounds 1, 3, 4, 5, 6 and 8 (3 and 4 were obtained as an unseparable mixture), were isolated as natural products for the first time. Compound 2, pregaliellalactone (5) and the mixture of 3 and 4 showed nematicidal activities towards Caenorhabditis elegans and Meloidogyne incognita. All compounds showed moderate or weak cytotoxic activities.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Antibiotics
volume
55
issue
1
pages
36 - 40
publisher
Japan Antibiotics Research Association
external identifiers
  • wos:000173536100006
  • scopus:0036171667
ISSN
0021-8820
language
English
LU publication?
yes
id
acdfa526-f459-4807-b105-d72b52d82be6 (old id 344136)
date added to LUP
2007-11-07 14:30:30
date last changed
2017-11-19 04:07:02
@article{acdfa526-f459-4807-b105-d72b52d82be6,
  abstract     = {Eight secondary metabolites were isolated from submerged cultures of the ascomycete A111-95 during a search for new nematicidal metabolites. (-)-Galiellalactone (7) and compound 2 are metabolites previously obtained from cultures of Galiella rufa while the compounds 1, 3, 4, 5, 6 and 8 (3 and 4 were obtained as an unseparable mixture), were isolated as natural products for the first time. Compound 2, pregaliellalactone (5) and the mixture of 3 and 4 showed nematicidal activities towards Caenorhabditis elegans and Meloidogyne incognita. All compounds showed moderate or weak cytotoxic activities.},
  author       = {Kopcke, B and Johansson, M and Sterner, Olov and Anke, H},
  issn         = {0021-8820},
  language     = {eng},
  number       = {1},
  pages        = {36--40},
  publisher    = {Japan Antibiotics Research Association},
  series       = {Journal of Antibiotics},
  title        = {Biologically active secondary metabolites from the ascomycete A111-95 - 1. Production, isolation and biological activities},
  volume       = {55},
  year         = {2002},
}