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Interleukin-6-deficient mice develop mature-onset obesity

Wallenius, V; Wallenius, K; Ahrén, Bo LU ; Rudling, M; Carlsten, H; Dickson, SL; Ohlsson, C and Jansson, JO (2002) In Nature Medicine 8(1). p.75-79
Abstract
The immune-modulating cytokine interleukin-6 (IL-6) its expressed both in adipose tissue and centrally in hypothalamic nuclei that regulate body composition. We investigated the impact of loss of IL-6 on body composition in mice lacking the gene encoding IL-6 (116(-/-) mice) and found that they developed mature-onset obesity that was partly reversed by IL-6 replacement: The obese 116(-/-) mice had disturbed carbohydrate and lipid metabolism, increased leptin levels and decreased responsiveness to leptin treatment. To investigate the possible mechanism and site of action of the anti-obesity effect of IL-6, we injected rats centrally and peripherally with IL-6 at low doses. Intracerebroventricular, but not intraperitoneal IL-6 treatment... (More)
The immune-modulating cytokine interleukin-6 (IL-6) its expressed both in adipose tissue and centrally in hypothalamic nuclei that regulate body composition. We investigated the impact of loss of IL-6 on body composition in mice lacking the gene encoding IL-6 (116(-/-) mice) and found that they developed mature-onset obesity that was partly reversed by IL-6 replacement: The obese 116(-/-) mice had disturbed carbohydrate and lipid metabolism, increased leptin levels and decreased responsiveness to leptin treatment. To investigate the possible mechanism and site of action of the anti-obesity effect of IL-6, we injected rats centrally and peripherally with IL-6 at low doses. Intracerebroventricular, but not intraperitoneal IL-6 treatment increased energy expenditure. In conclusion, centrally acting IL-6 exerts anti-obesity effects in rodents. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Medicine
volume
8
issue
1
pages
75 - 79
publisher
Nature Publishing Group
external identifiers
  • pmid:11786910
  • wos:000173056900034
  • scopus:0036152683
ISSN
1546-170X
DOI
10.1038/nm0102-75
language
English
LU publication?
yes
id
79a1c99c-7bd3-454c-b297-ce0f285daed4 (old id 346358)
date added to LUP
2007-11-16 12:24:37
date last changed
2017-12-10 04:27:45
@article{79a1c99c-7bd3-454c-b297-ce0f285daed4,
  abstract     = {The immune-modulating cytokine interleukin-6 (IL-6) its expressed both in adipose tissue and centrally in hypothalamic nuclei that regulate body composition. We investigated the impact of loss of IL-6 on body composition in mice lacking the gene encoding IL-6 (116(-/-) mice) and found that they developed mature-onset obesity that was partly reversed by IL-6 replacement: The obese 116(-/-) mice had disturbed carbohydrate and lipid metabolism, increased leptin levels and decreased responsiveness to leptin treatment. To investigate the possible mechanism and site of action of the anti-obesity effect of IL-6, we injected rats centrally and peripherally with IL-6 at low doses. Intracerebroventricular, but not intraperitoneal IL-6 treatment increased energy expenditure. In conclusion, centrally acting IL-6 exerts anti-obesity effects in rodents.},
  author       = {Wallenius, V and Wallenius, K and Ahrén, Bo and Rudling, M and Carlsten, H and Dickson, SL and Ohlsson, C and Jansson, JO},
  issn         = {1546-170X},
  language     = {eng},
  number       = {1},
  pages        = {75--79},
  publisher    = {Nature Publishing Group},
  series       = {Nature Medicine},
  title        = {Interleukin-6-deficient mice develop mature-onset obesity},
  url          = {http://dx.doi.org/10.1038/nm0102-75},
  volume       = {8},
  year         = {2002},
}