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Maternal dietary selenium intake during pregnancy is associated with higher birth weight and lower risk of small for gestational age births in the norwegian mother, father and child cohort study

Solé-Navais, Pol ; Brantsæter, Anne Lise ; Caspersen, Ida Henriette ; Lundh, Thomas LU ; Muglia, Louis J. ; Meltzer, Helle Margrete ; Zhang, Ge ; Jacobsson, Bo ; Sengpiel, Verena and Barman, Malin (2021) In Nutrients 13(1).
Abstract

Selenium is an essential trace element involved in the body’s redox reactions. Low selenium intake during pregnancy has been associated with low birth weight and an increased risk of children being born small for gestational age (SGA). Based on data from the Norwegian Mother, Father and Child Cohort Study (MoBa) and the Medical Birth Registry of Norway (MBRN), we studied the association of maternal selenium intake from diet and supplements during the first half of pregnancy (n = 71,728 women) and selenium status in mid-pregnancy (n = 2628 women) with birth weight and SGA status, according to population-based, ultrasound-based and customized growth standards. An increase of one standard deviation of maternal dietary selenium intake was... (More)

Selenium is an essential trace element involved in the body’s redox reactions. Low selenium intake during pregnancy has been associated with low birth weight and an increased risk of children being born small for gestational age (SGA). Based on data from the Norwegian Mother, Father and Child Cohort Study (MoBa) and the Medical Birth Registry of Norway (MBRN), we studied the association of maternal selenium intake from diet and supplements during the first half of pregnancy (n = 71,728 women) and selenium status in mid-pregnancy (n = 2628 women) with birth weight and SGA status, according to population-based, ultrasound-based and customized growth standards. An increase of one standard deviation of maternal dietary selenium intake was associated with increased birth weight z-scores (ß = 0.027, 95% CI: 0.007, 0.041) and lower SGA risk (OR = 0.91, 95% CI 0.86, 0.97) after adjusting for confounders. Maternal organic and inorganic selenium intake from supplements as well as whole blood selenium concentration were not associated with birth weight or SGA. Our results suggest that a maternal diet rich in selenium during pregnancy may be beneficial for foetal growth. However, the effect estimates were small and further studies are needed to elucidate the potential impact of selenium on foetal growth.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Birth weight, Intrauterine growth, MBRN, Medical Birth Registry of Norway, MoBa, Selenium, The Norwegian Mother, Father and Child Cohort study
in
Nutrients
volume
13
issue
1
article number
23
pages
16 pages
publisher
MDPI AG
external identifiers
  • scopus:85098659031
  • pmid:33374667
ISSN
2072-6643
DOI
10.3390/nu13010023
language
English
LU publication?
yes
id
351bd7bd-e1c2-4cb8-b277-ed3375c6131a
date added to LUP
2021-01-14 12:14:31
date last changed
2024-06-27 06:35:17
@article{351bd7bd-e1c2-4cb8-b277-ed3375c6131a,
  abstract     = {{<p>Selenium is an essential trace element involved in the body’s redox reactions. Low selenium intake during pregnancy has been associated with low birth weight and an increased risk of children being born small for gestational age (SGA). Based on data from the Norwegian Mother, Father and Child Cohort Study (MoBa) and the Medical Birth Registry of Norway (MBRN), we studied the association of maternal selenium intake from diet and supplements during the first half of pregnancy (n = 71,728 women) and selenium status in mid-pregnancy (n = 2628 women) with birth weight and SGA status, according to population-based, ultrasound-based and customized growth standards. An increase of one standard deviation of maternal dietary selenium intake was associated with increased birth weight z-scores (ß = 0.027, 95% CI: 0.007, 0.041) and lower SGA risk (OR = 0.91, 95% CI 0.86, 0.97) after adjusting for confounders. Maternal organic and inorganic selenium intake from supplements as well as whole blood selenium concentration were not associated with birth weight or SGA. Our results suggest that a maternal diet rich in selenium during pregnancy may be beneficial for foetal growth. However, the effect estimates were small and further studies are needed to elucidate the potential impact of selenium on foetal growth.</p>}},
  author       = {{Solé-Navais, Pol and Brantsæter, Anne Lise and Caspersen, Ida Henriette and Lundh, Thomas and Muglia, Louis J. and Meltzer, Helle Margrete and Zhang, Ge and Jacobsson, Bo and Sengpiel, Verena and Barman, Malin}},
  issn         = {{2072-6643}},
  keywords     = {{Birth weight; Intrauterine growth; MBRN; Medical Birth Registry of Norway; MoBa; Selenium; The Norwegian Mother, Father and Child Cohort study}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{MDPI AG}},
  series       = {{Nutrients}},
  title        = {{Maternal dietary selenium intake during pregnancy is associated with higher birth weight and lower risk of small for gestational age births in the norwegian mother, father and child cohort study}},
  url          = {{http://dx.doi.org/10.3390/nu13010023}},
  doi          = {{10.3390/nu13010023}},
  volume       = {{13}},
  year         = {{2021}},
}