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Cerebrospinal fluid insulin during non-neurological surgery

Bromander, Sara ; Anckarsater, Rolf ; Ahrén, Bo LU ; Kristiansson, Marianne ; Blennow, Kaj ; Holmang, Agneta ; Zetterberg, Henrik ; Anckarsäter, Henrik LU and Wass, Caroline E. (2010) In Journal of Neural Transmission 117(10). p.1167-1170
Abstract
Insulin plays an important metabolic and transmitter role in the central nervous system, but few studies have investigated the relationship between central and peripheral insulin concentrations. 35 patients undergoing knee surgery had cerebrospinal fluid (CSF) samples drawn before, 3 h after, and in the morning following surgery. Serum insulin concentrations increased after surgery and CSF insulin concentrations changed in the same direction with far smaller amplitude. These results indicate that the blood-brain barrier protects the brain from stress-induced peripheral hormonal fluctuations.
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Insulin, Cerebrospinal fluid, Surgical stress
in
Journal of Neural Transmission
volume
117
issue
10
pages
1167 - 1170
publisher
Springer
external identifiers
  • wos:000284782100006
  • scopus:78651254360
  • pmid:20697751
ISSN
0300-9564
DOI
10.1007/s00702-010-0456-x
language
English
LU publication?
yes
id
355b8883-d1b4-426b-8fa2-65b4bac19968 (old id 1751652)
date added to LUP
2016-04-01 14:56:45
date last changed
2024-12-06 05:12:23
@article{355b8883-d1b4-426b-8fa2-65b4bac19968,
  abstract     = {{Insulin plays an important metabolic and transmitter role in the central nervous system, but few studies have investigated the relationship between central and peripheral insulin concentrations. 35 patients undergoing knee surgery had cerebrospinal fluid (CSF) samples drawn before, 3 h after, and in the morning following surgery. Serum insulin concentrations increased after surgery and CSF insulin concentrations changed in the same direction with far smaller amplitude. These results indicate that the blood-brain barrier protects the brain from stress-induced peripheral hormonal fluctuations.}},
  author       = {{Bromander, Sara and Anckarsater, Rolf and Ahrén, Bo and Kristiansson, Marianne and Blennow, Kaj and Holmang, Agneta and Zetterberg, Henrik and Anckarsäter, Henrik and Wass, Caroline E.}},
  issn         = {{0300-9564}},
  keywords     = {{Insulin; Cerebrospinal fluid; Surgical stress}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1167--1170}},
  publisher    = {{Springer}},
  series       = {{Journal of Neural Transmission}},
  title        = {{Cerebrospinal fluid insulin during non-neurological surgery}},
  url          = {{http://dx.doi.org/10.1007/s00702-010-0456-x}},
  doi          = {{10.1007/s00702-010-0456-x}},
  volume       = {{117}},
  year         = {{2010}},
}