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Prediagnostic body fat and risk of death from amyotrophic lateral sclerosis: The EPIC cohort.

Gallo, Valentina; Wark, Petra A; Jenab, Mazda; Pearce, Neil; Brayne, Carol; Vermeulen, Roel; Andersen, Peter M; Hallmans, Goran; Kyrozis, Andreas and Vanacore, Nicola, et al. (2013) In Neurology 80(9). p.829-838
Abstract
OBJECTIVES: The aim of this study was to investigate for the first time the association between body fat and risk of amyotrophic lateral sclerosis (ALS) with an appropriate prospective study design. METHODS: The EPIC (European Prospective Investigation into Cancer and Nutrition) study included 518,108 individuals recruited from the general population across 10 Western European countries. At recruitment, information on lifestyle was collected and anthropometric characteristics were measured. Cox hazard models were fitted to investigate the associations between anthropometric measures and ALS mortality. RESULTS: Two hundred twenty-two ALS deaths (79 men and 143 women) occurred during the follow-up period (mean follow-up = 13 years). There... (More)
OBJECTIVES: The aim of this study was to investigate for the first time the association between body fat and risk of amyotrophic lateral sclerosis (ALS) with an appropriate prospective study design. METHODS: The EPIC (European Prospective Investigation into Cancer and Nutrition) study included 518,108 individuals recruited from the general population across 10 Western European countries. At recruitment, information on lifestyle was collected and anthropometric characteristics were measured. Cox hazard models were fitted to investigate the associations between anthropometric measures and ALS mortality. RESULTS: Two hundred twenty-two ALS deaths (79 men and 143 women) occurred during the follow-up period (mean follow-up = 13 years). There was a statistically significant interaction between categories of body mass index and sex regarding ALS risk (p = 0.009): in men, a significant linear decrease of risk per unit of body mass index was observed (hazard ratio = 0.93, 95% confidence interval 0.86-0.99 per kg/m(2)); among women, the risk was more than 3-fold increased for underweight compared with normal-weight women. Among women, a significant risk reduction increasing the waist/hip ratio was also evident: women in the top quartile had less than half the risk of ALS compared with those in the bottom quartile (hazard ratio = 0.48, 95% confidence interval 0.25-0.93) with a borderline significant p value for trend across quartiles (p = 0.056). CONCLUSION: Increased prediagnostic body fat is associated with a decreased risk of ALS mortality. (Less)
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Contribution to journal
publication status
published
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Neurology
volume
80
issue
9
pages
829 - 838
publisher
American Academy of Neurology
external identifiers
  • wos:000315451200017
  • pmid:23390184
  • scopus:84876332015
ISSN
1526-632X
DOI
10.1212/WNL.0b013e3182840689
language
English
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yes
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20f24410-00c7-46c2-8340-871852450752 (old id 3560048)
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http://www.ncbi.nlm.nih.gov/pubmed/23390184?dopt=Abstract
date added to LUP
2013-03-04 09:52:00
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2019-10-23 01:01:50
@article{20f24410-00c7-46c2-8340-871852450752,
  abstract     = {OBJECTIVES: The aim of this study was to investigate for the first time the association between body fat and risk of amyotrophic lateral sclerosis (ALS) with an appropriate prospective study design. METHODS: The EPIC (European Prospective Investigation into Cancer and Nutrition) study included 518,108 individuals recruited from the general population across 10 Western European countries. At recruitment, information on lifestyle was collected and anthropometric characteristics were measured. Cox hazard models were fitted to investigate the associations between anthropometric measures and ALS mortality. RESULTS: Two hundred twenty-two ALS deaths (79 men and 143 women) occurred during the follow-up period (mean follow-up = 13 years). There was a statistically significant interaction between categories of body mass index and sex regarding ALS risk (p = 0.009): in men, a significant linear decrease of risk per unit of body mass index was observed (hazard ratio = 0.93, 95% confidence interval 0.86-0.99 per kg/m(2)); among women, the risk was more than 3-fold increased for underweight compared with normal-weight women. Among women, a significant risk reduction increasing the waist/hip ratio was also evident: women in the top quartile had less than half the risk of ALS compared with those in the bottom quartile (hazard ratio = 0.48, 95% confidence interval 0.25-0.93) with a borderline significant p value for trend across quartiles (p = 0.056). CONCLUSION: Increased prediagnostic body fat is associated with a decreased risk of ALS mortality.},
  author       = {Gallo, Valentina and Wark, Petra A and Jenab, Mazda and Pearce, Neil and Brayne, Carol and Vermeulen, Roel and Andersen, Peter M and Hallmans, Goran and Kyrozis, Andreas and Vanacore, Nicola and Vahdaninia, Mariam and Grote, Verena and Kaaks, Rudolf and Mattiello, Amalia and Bueno-de-Mesquita, H Bas and Peeters, Petra H and Travis, Ruth C and Petersson, Jesper and Hansson, Oskar and Arriola, Larraitz and Jimenez-Martin, Juan-Manuel and Tjønneland, Anne and Halkjær, Jytte and Agnoli, Claudia and Sacerdote, Carlotta and Bonet, Catalina and Trichopoulou, Antonia and Gavrila, Diana and Overvad, Kim and Weiderpass, Elisabete and Palli, Domenico and Quirós, J Ramón and Tumino, Rosario and Khaw, Kay-Tee and Wareham, Nicholas and Barricante-Gurrea, Aurelio and Fedirko, Veronika and Ferrari, Pietro and Clavel-Chapelon, Françoise and Boutron-Ruault, Marie-Christine and Boeing, Heiner and Vigl, Matthaeus and Middleton, Lefkos and Riboli, Elio and Vineis, Paolo},
  issn         = {1526-632X},
  language     = {eng},
  number       = {9},
  pages        = {829--838},
  publisher    = {American Academy of Neurology},
  series       = {Neurology},
  title        = {Prediagnostic body fat and risk of death from amyotrophic lateral sclerosis: The EPIC cohort.},
  url          = {http://dx.doi.org/10.1212/WNL.0b013e3182840689},
  volume       = {80},
  year         = {2013},
}