Effects of blood ΔR(2)* non-linearity on absolute perfusion quantification using DSC-MRI: Comparison with Xe-133 SPECT.
Knutsson, Linda LU
; Ståhlberg, Freddy
LU
; Wirestam, Ronnie
LU
and van Osch, Matthias J
(2013)
In Magnetic Resonance Imaging
31(5).
p.651-655
- Abstract
- PURPOSE: To evaluate whether a non-linear blood ΔR(2)*-versus-concentration relationship improves quantitative cerebral blood flow (CBF) estimates obtained by dynamic susceptibility contrast (DSC) MRI in a comparison with Xe-133 SPECT CBF in healthy volunteers. MATERIAL AND METHODS: Linear as well as non-linear relationships between ΔR(2)* and contrast agent concentration in blood were applied to the arterial input function (AIF) and the venous output function (VOF) from DSC-MRI. To reduce partial volume effects in the AIF, the arterial time integral was rescaled using a corrected VOF scheme. RESULTS: Under the assumption of proportionality between the two modalities, the relationship CBF(MRI)=0.58CBF(SPECT) (r=0.64) was observed using the... (More)
- PURPOSE: To evaluate whether a non-linear blood ΔR(2)*-versus-concentration relationship improves quantitative cerebral blood flow (CBF) estimates obtained by dynamic susceptibility contrast (DSC) MRI in a comparison with Xe-133 SPECT CBF in healthy volunteers. MATERIAL AND METHODS: Linear as well as non-linear relationships between ΔR(2)* and contrast agent concentration in blood were applied to the arterial input function (AIF) and the venous output function (VOF) from DSC-MRI. To reduce partial volume effects in the AIF, the arterial time integral was rescaled using a corrected VOF scheme. RESULTS: Under the assumption of proportionality between the two modalities, the relationship CBF(MRI)=0.58CBF(SPECT) (r=0.64) was observed using the linear relationship and CBF(MRI)=0.51CBF(SPECT) (r=0.71) using the non-linear relationship. DISCUSSION: A smaller ratio of the VOF time integral to the AIF time integral and a somewhat better correlation between global DSC-MRI and Xe-133 SPECT CBF estimates were observed using the non-linear relationship. The results did not, however, confirm the superiority of one model over the other, potentially because realistic AIF signal data may well originate from a combination of blood and surrounding tissue. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3560246
- author
- Knutsson, Linda
LU
; Ståhlberg, Freddy
LU
; Wirestam, Ronnie
LU
and van Osch, Matthias J
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Magnetic Resonance Imaging
- volume
- 31
- issue
- 5
- pages
- 651 - 655
- publisher
- Elsevier
- external identifiers
-
- wos:000319103000003
- pmid:23375837
- scopus:84877113126
- pmid:23375837
- ISSN
- 1873-5894
- DOI
- 10.1016/j.mri.2012.12.001
- project
- Optimisation and Validation of Dynamic Susceptibility Contrast MRI
- language
- English
- LU publication?
- yes
- id
- c5a3bc5c-cb3a-4eaf-9f23-34fd5c2af5f5 (old id 3560246)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23375837?dopt=Abstract
- date added to LUP
- 2016-04-01 11:11:04
- date last changed
- 2022-01-26 06:01:47
@article{c5a3bc5c-cb3a-4eaf-9f23-34fd5c2af5f5,
abstract = {{PURPOSE: To evaluate whether a non-linear blood ΔR(2)*-versus-concentration relationship improves quantitative cerebral blood flow (CBF) estimates obtained by dynamic susceptibility contrast (DSC) MRI in a comparison with Xe-133 SPECT CBF in healthy volunteers. MATERIAL AND METHODS: Linear as well as non-linear relationships between ΔR(2)* and contrast agent concentration in blood were applied to the arterial input function (AIF) and the venous output function (VOF) from DSC-MRI. To reduce partial volume effects in the AIF, the arterial time integral was rescaled using a corrected VOF scheme. RESULTS: Under the assumption of proportionality between the two modalities, the relationship CBF(MRI)=0.58CBF(SPECT) (r=0.64) was observed using the linear relationship and CBF(MRI)=0.51CBF(SPECT) (r=0.71) using the non-linear relationship. DISCUSSION: A smaller ratio of the VOF time integral to the AIF time integral and a somewhat better correlation between global DSC-MRI and Xe-133 SPECT CBF estimates were observed using the non-linear relationship. The results did not, however, confirm the superiority of one model over the other, potentially because realistic AIF signal data may well originate from a combination of blood and surrounding tissue.}},
author = {{Knutsson, Linda and Ståhlberg, Freddy and Wirestam, Ronnie and van Osch, Matthias J}},
issn = {{1873-5894}},
language = {{eng}},
number = {{5}},
pages = {{651--655}},
publisher = {{Elsevier}},
series = {{Magnetic Resonance Imaging}},
title = {{Effects of blood ΔR(2)* non-linearity on absolute perfusion quantification using DSC-MRI: Comparison with Xe-133 SPECT.}},
url = {{https://lup.lub.lu.se/search/files/2450125/3632135.pdf}},
doi = {{10.1016/j.mri.2012.12.001}},
volume = {{31}},
year = {{2013}},
}