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Brain tumour development in rats exposed to electromagnetic fields used in wireless cellular communication

Salford, Leif LU ; Brun, Arne LU and Persson, Bertil R LU (1997) In Wireless Networks 3. p.463-468
Abstract
It has been suggested that electromagnetic fields (EMF) act as promoters late in the carcinogenesis process. To date, however, there is no convincing laboratory evidence that EMFs cause tumour promotion at non-thermal exposure levels. Therefore the effects of exposure to electromagnetic fields were investigated in a rat brain glioma model. Some of the exposures correspond to electromagnetic fields used in wireless communication. Microwaves at 915 MHz were used both as continuous waves (1 W), and pulse-modulated at 4, 8, 16 and 217 Hz in 0.57 ms pulses and 50 Hz in 6.67 ms pulses (2 W per pulse). Fischer 344 rats of both sexes were used in the

experiments. By stereotaxic technique rat glioma cells (RG2 and N32) were injected into... (More)
It has been suggested that electromagnetic fields (EMF) act as promoters late in the carcinogenesis process. To date, however, there is no convincing laboratory evidence that EMFs cause tumour promotion at non-thermal exposure levels. Therefore the effects of exposure to electromagnetic fields were investigated in a rat brain glioma model. Some of the exposures correspond to electromagnetic fields used in wireless communication. Microwaves at 915 MHz were used both as continuous waves (1 W), and pulse-modulated at 4, 8, 16 and 217 Hz in 0.57 ms pulses and 50 Hz in 6.67 ms pulses (2 W per pulse). Fischer 344 rats of both sexes were used in the

experiments. By stereotaxic technique rat glioma cells (RG2 and N32) were injected into the head of the right caudate nucleus in 154 pairs of rats, exposed and matched controls. Starting on day 5 after inoculation, the animals were exposed for 7 hours a day, 5 days a week during 2–3 weeks. Exposed animals were kept unanaesthetized in well-ventilated TEM cells producing 915 MHz continuous or modulated microwaves. Their matched controls were kept in identical TEM cells without EMF exposure. All brains were examined histopathologically and the tumour size was estimated as the volume of an ellipsoid. Our study of 154 matched pairs of rats does not show any significant difference in tumour size between animals exposed to 915 MHz, and those not exposed. Thus our results do not support that even an extensive daily exposure to EMF promotes tumour growth when given from the fifth day after the start of tumour growth in the rat brain until the sacrifice of the animal after about 16 days. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
tumour, Brain, rats, electromagnetic, fields, wireless, cellular, communication
in
Wireless Networks
volume
3
pages
463 - 468
publisher
J.C. Baltzer AG, Science Publishers
external identifiers
  • scopus:0031273976
ISSN
1022-0038
language
English
LU publication?
yes
id
8dd34ccf-8368-4d75-a14d-55c024acbe16 (old id 3634004)
date added to LUP
2015-04-14 21:31:21
date last changed
2017-01-01 07:15:22
@article{8dd34ccf-8368-4d75-a14d-55c024acbe16,
  abstract     = {It has been suggested that electromagnetic fields (EMF) act as promoters late in the carcinogenesis process. To date, however, there is no convincing laboratory evidence that EMFs cause tumour promotion at non-thermal exposure levels. Therefore the effects of exposure to electromagnetic fields were investigated in a rat brain glioma model. Some of the exposures correspond to electromagnetic fields used in wireless communication. Microwaves at 915 MHz were used both as continuous waves (1 W), and pulse-modulated at 4, 8, 16 and 217 Hz in 0.57 ms pulses and 50 Hz in 6.67 ms pulses (2 W per pulse). Fischer 344 rats of both sexes were used in the<br/><br>
experiments. By stereotaxic technique rat glioma cells (RG2 and N32) were injected into the head of the right caudate nucleus in 154 pairs of rats, exposed and matched controls. Starting on day 5 after inoculation, the animals were exposed for 7 hours a day, 5 days a week during 2–3 weeks. Exposed animals were kept unanaesthetized in well-ventilated TEM cells producing 915 MHz continuous or modulated microwaves. Their matched controls were kept in identical TEM cells without EMF exposure. All brains were examined histopathologically and the tumour size was estimated as the volume of an ellipsoid. Our study of 154 matched pairs of rats does not show any significant difference in tumour size between animals exposed to 915 MHz, and those not exposed. Thus our results do not support that even an extensive daily exposure to EMF promotes tumour growth when given from the fifth day after the start of tumour growth in the rat brain until the sacrifice of the animal after about 16 days.},
  author       = {Salford, Leif and Brun, Arne and Persson, Bertil R},
  issn         = {1022-0038},
  keyword      = {tumour,Brain,rats,electromagnetic,fields,wireless,cellular,communication},
  language     = {eng},
  pages        = {463--468},
  publisher    = {J.C. Baltzer AG, Science Publishers},
  series       = {Wireless Networks},
  title        = {Brain tumour development in rats exposed to electromagnetic fields used in wireless cellular communication},
  volume       = {3},
  year         = {1997},
}