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Biomarkers of exposure in Monday morning urine samples as a long-term measure of exposure to aromatic diisocyanates.

Tinnerberg, Håkan LU ; Broberg Palmgren, Karin LU ; Lindh, Christian LU and Jönsson, Bo A LU (2014) In International Archives of Occupational and Environmental Health 87(4). p.365-372
Abstract
PURPOSE: Exposure to diisocyanates is a known occupational hazard. One method for monitoring occupational exposure is by analyzing biomarkers in hydrolyzed urine and plasma. The half-life of the biomarkers in plasma is about 3 weeks, and the urinary elimination is divided into one fast (hours) and one slow phases (weeks). Polymorphism in glutathione S-transferase enzymes (GST) is earlier shown to modify the metabolism. The aim of the study was to assess whether biomarkers of exposure in urine collected after two non-exposed days correlate with levels in plasma and whether they can be used as a measure for long-term exposure to aromatic diisocyanates and further whether polymorphisms in GST influenced the correlations. METHODS: Biomarkers... (More)
PURPOSE: Exposure to diisocyanates is a known occupational hazard. One method for monitoring occupational exposure is by analyzing biomarkers in hydrolyzed urine and plasma. The half-life of the biomarkers in plasma is about 3 weeks, and the urinary elimination is divided into one fast (hours) and one slow phases (weeks). Polymorphism in glutathione S-transferase enzymes (GST) is earlier shown to modify the metabolism. The aim of the study was to assess whether biomarkers of exposure in urine collected after two non-exposed days correlate with levels in plasma and whether they can be used as a measure for long-term exposure to aromatic diisocyanates and further whether polymorphisms in GST influenced the correlations. METHODS: Biomarkers of exposure was analyzed in urine and blood samples collected from 24 workers, exposed to at least one of toluene-, methylenediphenyl- or naphthalene diisocyanate, on a Monday morning after at least two unexposed days. Moreover, genotype was determined for 19 of the workers. RESULTS: The corresponding specific gravity-adjusted biomarkers in urine and plasma levels for the different diisocyanates correlated well (r between 0.689 and 0.988). When taking all samples together, the correlation coefficient was 0.926. Polymorphism in the GSTM1 genotype seemed to modify the association. CONCLUSION: Urine collected after two unexposed days can possibly be used as long-term biomarker of exposure for aromatic diisocyanates. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Archives of Occupational and Environmental Health
volume
87
issue
4
pages
365 - 372
publisher
Springer
external identifiers
  • pmid:23558852
  • wos:000334933600002
  • scopus:84901001107
ISSN
1432-1246
DOI
10.1007/s00420-013-0872-y
language
English
LU publication?
yes
id
d96d66d9-3ba1-43a9-bf98-d6b7ea2e602b (old id 3734120)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23558852?dopt=Abstract
date added to LUP
2013-05-04 16:44:11
date last changed
2017-01-01 04:17:21
@article{d96d66d9-3ba1-43a9-bf98-d6b7ea2e602b,
  abstract     = {PURPOSE: Exposure to diisocyanates is a known occupational hazard. One method for monitoring occupational exposure is by analyzing biomarkers in hydrolyzed urine and plasma. The half-life of the biomarkers in plasma is about 3 weeks, and the urinary elimination is divided into one fast (hours) and one slow phases (weeks). Polymorphism in glutathione S-transferase enzymes (GST) is earlier shown to modify the metabolism. The aim of the study was to assess whether biomarkers of exposure in urine collected after two non-exposed days correlate with levels in plasma and whether they can be used as a measure for long-term exposure to aromatic diisocyanates and further whether polymorphisms in GST influenced the correlations. METHODS: Biomarkers of exposure was analyzed in urine and blood samples collected from 24 workers, exposed to at least one of toluene-, methylenediphenyl- or naphthalene diisocyanate, on a Monday morning after at least two unexposed days. Moreover, genotype was determined for 19 of the workers. RESULTS: The corresponding specific gravity-adjusted biomarkers in urine and plasma levels for the different diisocyanates correlated well (r between 0.689 and 0.988). When taking all samples together, the correlation coefficient was 0.926. Polymorphism in the GSTM1 genotype seemed to modify the association. CONCLUSION: Urine collected after two unexposed days can possibly be used as long-term biomarker of exposure for aromatic diisocyanates.},
  author       = {Tinnerberg, Håkan and Broberg Palmgren, Karin and Lindh, Christian and Jönsson, Bo A},
  issn         = {1432-1246},
  language     = {eng},
  number       = {4},
  pages        = {365--372},
  publisher    = {Springer},
  series       = {International Archives of Occupational and Environmental Health},
  title        = {Biomarkers of exposure in Monday morning urine samples as a long-term measure of exposure to aromatic diisocyanates.},
  url          = {http://dx.doi.org/10.1007/s00420-013-0872-y},
  volume       = {87},
  year         = {2014},
}